(Q56397856)

6

object named as

Antony J. Williams

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author name string

Michael-R. Goldsmith

2

0 references

Aniko Simon

3

0 references

Zsolt Zsoldos

4

0 references

Orr Ravitz

Journal of Computational Medicine

5

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publication date

2013

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published in

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volume

2013

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page(s)

1-8

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copyright license

Creative Commons Attribution 3.0 Unported

start time

24 June 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

1 reference

April 2022 Public Data File from Crossref

cites work

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Fifteen years after "Wingspread"--environmental endocrine disrupters and human and wildlife health: where we are today and where we need to go

21 January 2018

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Nuclear receptors: structure, function and involvement in disease

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Bile acids and derivatives, their nuclear receptors FXR, PXR and ligands: role in health and disease and their therapeutic potential

21 January 2018

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PPAR modulators and PPAR pan agonists for metabolic diseases: the next generation of drugs targeting peroxisome proliferator-activated receptors?

21 January 2018

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Nuclear receptors as potential molecular targets in cholesterol accumulation conditions: insights from evidence on hepatic cholesterol degradation and gallstone disease in humans.

21 January 2018

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Endocrine-disrupting chemicals use distinct mechanisms of action to modulate endocrine system function

21 January 2018

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Intrinsic disorder in nuclear hormone receptors

21 January 2018

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Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist

21 January 2018

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Molecular basis of agonism and antagonism in the oestrogen receptor

21 January 2018

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DNA recognition by the oestrogen receptor: from solution to the crystal

21 January 2018

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Crystallographic structures of the ligand-binding domains of the androgen receptor and its T877A mutant complexed with the natural agonist dihydrotestosterone

21 January 2018

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A ligand-based approach to identify quantitative structure-activity relationships for the androgen receptor

21 January 2018

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Structural basis of androgen receptor binding to selective androgen response elements.

21 January 2018

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Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

21 January 2018

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SXR, a novel steroid and xenobiotic-sensing nuclear receptor

21 January 2018

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An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

21 January 2018

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Activation of the steroid and xenobiotic receptor, SXR, induces apoptosis in breast cancer cells

21 January 2018

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Expanding the roles for pregnane X receptor in cancer: proliferation and drug resistance in ovarian cancer

21 January 2018

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The antiapoptotic role of pregnane X receptor in human colon cancer cells

21 January 2018

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Elucidating the 'Jekyll and Hyde' nature of PXR: the case for discovering antagonists or allosteric antagonists

21 January 2018

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Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: implications for interindividual variability in response to drugs

21 January 2018

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Challenges predicting ligand-receptor interactions of promiscuous proteins: the nuclear receptor PXR

21 January 2018

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Computational models for predicting the binding affinities of ligands for the wild-type androgen receptor and a mutated variant associated with human prostate cancer

21 January 2018

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In silico tools to aid risk assessment of endocrine disrupting chemicals

21 January 2018

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A ligand-based approach to understanding selectivity of nuclear hormone receptors PXR, CAR, FXR, LXRalpha, and LXRbeta

21 January 2018

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Quantitative structure-activity relationship of various endogenous estrogen metabolites for human estrogen receptor alpha and beta subtypes: Insights into the structural determinants favoring a differential subtype binding

21 January 2018

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Target specific compound identification using a support vector machine.

21 January 2018

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Structure-based virtual screening for plant-based ERbeta-selective ligands as potential preventative therapy against age-related neurodegenerative diseases

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Discovery of antiandrogen activity of nonsteroidal scaffolds of marketed drugs

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Nature of the binding interaction for 50 structurally diverse chemicals with rat estrogen receptors.

21 January 2018

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Molecular modeling for screening environmental chemicals for estrogenicity: use of the toxicant-target approach

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Study of 202 Natural, Synthetic, and Environmental Chemicals for Binding to the Androgen Receptor

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The BridgeDb framework: standardized access to gene, protein and metabolite identifier mapping services

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Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor

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2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin

21 January 2018

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Crystal structure of the PXR–T1317 complex provides a scaffold to examine the potential for receptor antagonism

21 January 2018

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Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin

21 January 2018

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Structural basis of human pregnane X receptor activation by the hops constituent colupulone

21 January 2018

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The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

21 January 2018

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PXR and the regulation of apoA1 and HDL-cholesterol in rodents

21 January 2018

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Human pregnane X receptor antagonists and agonists define molecular requirements for different binding sites

21 January 2018

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A pharmacophore for human pregnane X receptor ligands

21 January 2018

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The identification of ligand features essential for PXR activation by pharmacophore modeling

21 January 2018

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A comprehensive in vitro and in silico analysis of antibiotics that activate pregnane X receptor and induce CYP3A4 in liver and intestine

21 January 2018

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Machine learning methods and docking for predicting human pregnane X receptor activation

21 January 2018

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Hybrid scoring and classification approaches to predict human pregnane X receptor activators

21 January 2018

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Evolution of pharmacologic specificity in the pregnane X receptor

21 January 2018

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Evaluation of computational docking to identify pregnane X receptor agonists in the ToxCast database

21 January 2018

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Troubleshooting computational methods in drug discovery

21 January 2018

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Understanding nuclear receptors using computational methods

21 January 2018

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LASSO-ligand activity by surface similarity order: a new tool for ligand based virtual screening.

21 January 2018

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Benchmarking sets for molecular docking

21 January 2018

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In silico prediction of pregnane X receptor activators by machine learning approaches.

21 January 2018

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Comparison of topological, shape, and docking methods in virtual screening.

21 January 2018

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Characterization of steroid receptors in human prostate using mibolerone

21 January 2018

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Toward a Comprehensive Molecular Design Framework for Reduced Hazard

21 January 2018

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