(Q56531047)

13

object named as

Barry R O'Keefe

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author name string

Alun Bermingham

1

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Edmund Price

2

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Christophe Marchand

3

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Adel Chergui

4

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Alena Naumova

5

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Emily L Whitson

6

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Lauren R H Krumpe

7

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Ekaterina I Goncharova

8

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Jason R Evans

9

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Tawnya C McKee

10

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Curtis J Henrich

DNA topoisomerases: structure, function, and mechanism

11

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language of work or name

English

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publication date

1 July 2017

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page(s)

2472555217717200

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cites work

1 reference

https://api.crossref.org/works/10.1177%2F2472555217717200

Targeted disruption of the mouse topoisomerase I gene by camptothecin selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F2472555217717200

DNA topoisomerases as anticancer drug targets: from the laboratory to the clinic

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F2472555217717200

The tyrosyl-DNA phosphodiesterase Tdp1 is a member of the phospholipase D superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F2472555217717200

Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F2472555217717200

A eukaryotic enzyme that can disjoin dead-end covalent complexes between DNA and type I topoisomerases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F2472555217717200

Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F2472555217717200

Mutation of TDP1, encoding a topoisomerase I-dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F2472555217717200

SCAN1 mutant Tdp1 accumulates the enzyme--DNA intermediate and causes camptothecin hypersensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F2472555217717200

Synthesis and biological evaluation of nitrated 7-, 8-, 9-, and 10-hydroxyindenoisoquinolines as potential dual topoisomerase I (Top1)-tyrosyl-DNA phosphodiesterase I (TDP1) inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F2472555217717200

Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F2472555217717200

Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs DNA damage induced by topoisomerases I and II and base alkylation in vertebrate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F2472555217717200

TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F2472555217717200

Natural Products as Sources of New Drugs from 1981 to 2014.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F2472555217717200

Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F2472555217717200

Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F2472555217717200

4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesulfonate) (NSC 88915) and related novel steroid derivatives as tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F2472555217717200

High throughput extraction of plant, marine and fungal specimens for preservation of biologically active molecules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F2472555217717200

Deguelins, Natural Product Modulators of NF1-Defective Astrocytoma Cell Growth Identified by High-Throughput Screening of Partially Purified Natural Product Extracts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F2472555217717200

Marine sponge polyketide inhibitors of protein tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F2472555217717200

Synergistic TRAIL sensitizers from Barleria alluaudii and Diospyros maritima

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F2472555217717200

Development of Novel Assays for Proteolytic Enzymes Using Rhodamine-Based Fluorogenic Substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F2472555217717200

Identification of inhibitors for MDM2 ubiquitin ligase activity from natural product extracts by a novel high-throughput electrochemiluminescent screen

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F2472555217717200

Interaction of aurintricarboxylic acid (ATA) with four nucleic acid binding proteins DNase I, RNase A, reverse transcriptase and Taq polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F2472555217717200

Aurintricarboxylic acid is a potent inhibitor of influenza A and B virus neuraminidases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F2472555217717200

Absolute stereochemistry and anti-HIV activity of minquartynoic acid, a polyacetylene from Ochanostachys amentacea

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F2472555217717200

Halenaquinone, a novel phosphatidylinositol 3-kinase inhibitor from a marine sponge, induces apoptosis in PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F2472555217717200

Protein-reactive natural products

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F2472555217717200

Chemical and biological explorations of the electrophilic reactivity of the bioactive marine natural product halenaquinone with biomimetic nucleophiles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F2472555217717200

Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F2472555217717200

Impact of natural products on developing new anti-cancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F2472555217717200

The roots of modern oncology: from discovery of new antitumor anthracyclines to their clinical use.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F2472555217717200

Drug discovery and natural products: end of an era or an endless frontier?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F2472555217717200

Ready for a comeback of natural products in oncology

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F2472555217717200

Principles of Fluorescence Spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F2472555217717200

Daphnetin: a Novel Antimalarial Agent with in Vitro and in Vivo Activity

21 January 2018

1 reference

12 December 2020

Camptothecin and taxol: discovery to clinic--thirteenth Bruce F. Cain Memorial Award Lecture

1 reference

12 December 2020

The response of eukaryotic topoisomerases to DNA damage

1 reference

12 December 2020

Evaluation of enzyme inhibitors in drug discovery. A guide for medicinal chemists and pharmacologists

1 reference

12 December 2020

The Topoisomerase I Inhibitor Irinotecan and the Tyrosyl-DNA Phosphodiesterase 1 Inhibitor Furamidine Synergistically Suppress Murine Lupus Nephritis

1 reference

12 December 2020