(Q56687985)

4

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Chris de Graaf

object named as

Chris de Graaf

9

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author name string

Sabine Schultes

1

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Harald Engelhardt

3

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Henry F. Vischer

5

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Iwan J. P. de Esch

6

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Eric E. J. Haaksma

7

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Rob Leurs

Synthesis and structure-activity relationships of cyanoguanidine-type and structurally related histamine H4 receptor agonists

8

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publication date

2013

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published in

MedChemComm

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volume

4

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issue

1

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page(s)

193-204

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cites work

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Molecular determinants of ligand binding modes in the histamine H(4) receptor: linking ligand-based three-dimensional quantitative structure-activity relationship (3D-QSAR) models to in silico guided receptor mutagenesis studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Delineation of agonist binding to the human histamine H4 receptor using mutational analysis, homology modeling, and ab initio calculations

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Molecular determinants of ligand binding to H4R species variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Phenylalanine 169 in the second extracellular loop of the human histamine H4 receptor is responsible for the difference in agonist binding between human and mouse H4 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Structural requirements for inverse agonism and neutral antagonism of indole-, benzimidazole-, and thienopyrrole-derived histamine H4 receptor ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Molecular modeling and site-specific mutagenesis of the histamine-binding site of the histamine H4 receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Antiinflammatory and antinociceptive effects of the selective histamine H4-receptor antagonists JNJ7777120 and VUF6002 in a rat model of carrageenan-induced acute inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Histamine H4 receptor antagonism diminishes existing airway inflammation and dysfunction via modulation of Th2 cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Histamine h(4) and h(2) receptors control histamine-induced interleukin-16 release from human CD8(+) T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Histamine H4 receptor mediates chemotaxis and calcium mobilization of mast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

H4 receptor antagonism exhibits anti-nociceptive effects in inflammatory and neuropathic pain models in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

The emerging role of the histamine H4 receptor in anti-inflammatory therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Identification of a histamine H4 receptor on human eosinophils--role in eosinophil chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Histamine H4 receptor antagonism reduces hapten-induced scratching behaviour but not inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Diversity and modularity of G protein-coupled receptor structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Structure of the human histamine H1 receptor complex with doxepin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Crystal structure-based virtual screening for fragment-like ligands of the human histamine H(1) receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Discovery of novel human histamine H4 receptor ligands by large-scale structure-based virtual screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Homology model adjustment and ligand screening with a pseudoreceptor of the human histamine H4 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Molecular determinants of selective agonist and antagonist binding to the histamine H₄ receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Major advances in the development of histamine H4 receptor ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

The binding site of aminergic G protein-coupled receptors: the transmembrane segments and second extracellular loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Detailed structure-activity relationship of indolecarboxamides as H4 receptor ligands.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

The first potent and selective non-imidazole human histamine H4 receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Binding mode analysis and enrichment studies on homology models of the human histamine H4 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Structure-activity studies on a series of a 2-aminopyrimidine-containing histamine H4 receptor ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Challenges of drug discovery in novel target space. The discovery and evaluation of PF-3893787: a novel histamine H4 receptor antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

2,4-Diaminopyrimidines as histamine H4 receptor ligands--Scaffold optimization and pharmacological characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

In silico characterization of ligand binding modes in the human histamine H4 receptor and their impact on receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Metabolic regio- and stereoselectivity of cytochrome P450 2D6 towards 3,4-methylenedioxy-N-alkylamphetamines: in silico predictions and experimental validation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Structure and dynamics of the M3 muscarinic acetylcholine receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Empirical scoring functions for advanced protein-ligand docking with PLANTS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Development, validation, and application of adapted PEOE charges to estimate pKa values of functional groups in protein-ligand complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H4 receptor agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Customizing G Protein-coupled receptor models for structure-based virtual screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Successful prediction of the intra- and extracellular loops of four G-protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Molecular modeling of the second extracellular loop of G-protein coupled receptors and its implication on structure-based virtual screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Improved ligand-protein binding affinity predictions using multiple binding modes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

A G(q/11)-coupled mutant histamine H(1) receptor F435A activated solely by synthetic ligands (RASSL).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Study of Human Orexin-1 and -2 G-Protein-Coupled Receptors with Novel and Published Antagonists by Modeling, Molecular Dynamics Simulations, and Site-Directed Mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Multiwavelength spectrophotometric determination of acid dissociation constants of ionizable drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Potentiometric and spectrophotometric pKa determination of water-insoluble compounds: validation study in a new cosolvent system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

An activation switch in the rhodopsin family of G protein-coupled receptors: the thyrotropin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

A point-charge force field for molecular mechanics simulations of proteins based on condensed-phase quantum mechanical calculations

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Development and testing of a general amber force field

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Automatic atom type and bond type perception in molecular mechanical calculations

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Optimizing fragment and scaffold docking by use of molecular interaction fingerprints

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

POVME: an algorithm for measuring binding-pocket volumes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Triazole Ligands Reveal Distinct Molecular Features That Induce Histamine H4Receptor Affinity and Subtly Govern H4/H3Subtype Selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Triamino pyrimidines and pyridines as histamine H4 receptor modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C

Molecular dynamics with coupling to an external bath

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MD20212C