(Q56762869)

1

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D. Malcolm Duckworth

2

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L J Beeley

1

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D M Duckworth

2

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C Southan

Progress in medicinal chemistry

3

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language of work or name

English

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publication date

2000

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published in

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volume

37

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page(s)

1-43

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cites work

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7 January 2021

Human Genome Project aims to finish ‘working draft’ next year

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The SWISS-PROT protein sequence data bank and its supplement TrEMBL in 1999.

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The PIR-International Protein Sequence Database

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7 January 2021

The human genome project: past, present, and future

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7 January 2021

The complete genome sequence of Escherichia coli K-12

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7 January 2021

The complete genome sequence of the gastric pathogen Helicobacter pylori

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7 January 2021

Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori

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7 January 2021

The genome sequence of Rickettsia prowazekii and the origin of mitochondria

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7 January 2021

The complete genome sequence of the gram-positive bacterium Bacillus subtilis

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7 January 2021

The Minimal Gene Complement of Mycoplasma genitalium

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7 January 2021

Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae

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7 January 2021

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

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7 January 2021

Genome Sequence of an Obligate Intracellular Pathogen of Humans: Chlamydia trachomatis

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7 January 2021

Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi

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7 January 2021

Complete Genome Sequence of Treponema pallidum, the Syphilis Spirochete

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7 January 2021

The complete genome of the hyperthermophilic bacterium Aquifex aeolicus

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7 January 2021

Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions (supplement).

1 reference

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7 January 2021

Sequence Analysis of the Genome of the Unicellular Cyanobacterium Synechocystis sp. Strain PCC6803. II. Sequence Determination of the Entire Genome and Assignment of Potential Protein-coding Regions

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7 January 2021

Complete Genome Sequence of the Methanogenic Archaeon, Methanococcus jannaschii

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7 January 2021

Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics

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7 January 2021

The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus

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7 January 2021

Complete sequence and gene organization of the genome of a hyper-thermophilic archaebacterium, Pyrococcus horikoshii OT3 (supplement).

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Complete Sequence and Gene Organization of the Genome of a Hyper-thermophilic Archaebacterium, Pyrococcus horikoshii OT3

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Genome sequence of the nematode C. elegans: a platform for investigating biology

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7 January 2021

Basic local alignment search tool

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Empirical statistical estimates for sequence similarity searches.

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

GABA(B)-receptor subtypes assemble into functional heteromeric complexes.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Heterodimerization is required for the formation of a functional GABA(B) receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

The 5-HT3B subunit is a major determinant of serotonin-receptor function

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Molecular characterization of the human beta 3-adrenergic receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Positional cloning of the mouse obese gene and its human homologue

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

New opportunities for uncovering the molecular basis of cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Laser capture microdissection: molecular analysis of tissue

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Discovery and analysis of inflammatory disease-related genes using cDNA microarrays

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

The transcriptional program in the response of human fibroblasts to serum

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Exploring the new world of the genome with DNA microarrays

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

DNA microarrays in drug discovery and development

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Options available--from start to finish--for obtaining expression data by microarray.

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Protein identification in the post-genome era: the rapid rise of proteomics

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Proteome analysis: genomics via the output rather than the input code

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Comprehensive two-dimensional high-performance liquid chromatography for the isolation of overexpressed proteins and proteome mapping

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Human and mouse proteomic databases: novel resources in the protein universe.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Simultaneous measurement of hundreds of liver proteins: application in assessment of liver function

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

A comparison of selected mRNA and protein abundances in human liver

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Programmed cell death in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

The embryonic expression pattern of 40 murine cDNAs homologous to Drosophila mutant genes (Dres): a comparative and topographic approach to predict gene function.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Drosophila-related expressed sequences

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Circadian rhythms. An end in the beginning

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Positionally cloned human disease genes: patterns of evolutionary conservation and functional motifs

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Genome cross-referencing and XREFdb: implications for the identification and analysis of genes mutated in human disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Regulation of the insulin signalling pathway by cellular protein-tyrosine phosphatases

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

An induction gene trap screen in embryonic stem cells: Identification of genes that respond to retinoic acid in vitro.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Mouse embryonic stem cells and reporter constructs to detect developmentally regulated genes.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Capturing genes encoding membrane and secreted proteins important for mouse development

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

A gene trap approach in mouse embryonic stem cells: the lacZ reported is activated by splicing, reflects endogenous gene expression, and is mutagenic in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Selective disruption of genes expressed in totipotent embryonal stem cells

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Evidence for the stochastic integration of gene trap vectors into the mouse germline

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Functional genomics in mice by tagged sequence mutagenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Sequence-structure matching in globular proteins: application to supersecondary and tertiary structure determination

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Protein fold recognition by prediction-based threading

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Hematopoietin sub-family classification based on size, gene organization and sequence homology

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Signaling by the cytokine receptor superfamily: JAKs and STATs.

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

The Argonne Structural Genomics Workshop: Lamaze class for the birth of a new science

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Structural genomics: bioinformatics in the driver's seat

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Shining a light on structural genomics.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Structural genomics: keystone for a Human Proteome Project

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

One thousand families for the molecular biologist

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

SCOP: a Structural Classification of Proteins database

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Pfam 3.1: 1313 multiple alignments and profile HMMs match the majority of proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

100,000 protein structures for the biologist

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

ProMod and Swiss-Model: Internet-based tools for automated comparative protein modelling

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

X-ray structure of bacteriorhodopsin at 2.5 angstroms from microcrystals grown in lipidic cubic phases

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Conserved polar residues in the transmembrane domain of the human tachykinin NK2 receptor: functional roles and structural implications

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Structure of the MscL homolog from Mycobacterium tuberculosis: a gated mechanosensitive ion channel

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

A structural census of genomes: comparing bacterial, eukaryotic, and archaeal genomes in terms of protein structure

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

A structural census of the current population of protein sequences

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Parallel personal comments on "classical" papers in combinatorial chemistry

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

New methods in combinatorial chemistry-robotics and parallel synthesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Combinatorial chemistry

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Complex synthetic chemical libraries indexed with molecular tags

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Encoding methods for combinatorial chemistry

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Encoding strategies in combinatorial chemistry

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Design of self-coded combinatorial libraries to facilitate direct analysis of ligands by mass spectrometry

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Molecular Diversity and Representativity in Chemical Databases

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

A knowledge-based approach in designing combinatorial or medicinal chemistry libraries for drug discovery. 1. A qualitative and quantitative characterization of known drug databases

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Beyond mere diversity: tailoring combinatorial libraries for drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Metric Validation and the Receptor-Relevant Subspace Concept

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Comprehensive survey of chemical libraries yielding enzyme inhibitors, receptor agonists and antagonists, and other biologically active agents: 1992 through 1997.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Carbohydrate-based combinatorial libraries

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

The chemical-biological interface: developments in automated and miniaturised screening technology

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

The application of high-throughput screening to novel lead discovery

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Orphan G-protein-coupled receptors: the next generation of drug targets?

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

A cortical neuropeptide with neuronal depressant and sleep-modulating properties

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Identification and characterization of a novel human cortistatin-like peptide

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Functional genomics: the search for novel neurotransmitters and neuropeptides

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Yeast alpha mating factor structure-activity relationship derived from genetically selected peptide agonists and antagonists of Ste2p

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

High-throughput screening for drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Identification of surrogate agonists for the human FPRL-1 receptor by autocrine selection in yeast.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Orphanin FQ: a neuropeptide that activates an opioidlike G protein-coupled receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

The signature sequence of voltage-gated potassium channels projects into the external vestibule

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Molecular cloning and characterization of the human anaphylatoxin C3a receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

A prolactin-releasing peptide in the brain

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

EDG1 is a functional sphingosine-1-phosphate receptor that is linked via a Gi/o to multiple signaling pathways, including phospholipase C activation, Ca2+ mobilization, Ras-mitogen-activated protein kinase activation, and adenylate cyclase inhibitio

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Blunting nature's Swiss army knife

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Protease substrate specificity mapping using membrane-bound peptides

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Substrate phage: selection of protease substrates by monovalent phage display

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Characterization of myelin-associated glycoprotein (MAG) proteolysis in the human central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclasts

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Genomic organization and chromosome localization of the human cathepsin K gene (CTSK)

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Structure and chromosomal assignment of the human cathepsin K gene

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Cathepsin K antisense oligodeoxynucleotide inhibits osteoclastic bone resorption

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

The collagenolytic activity of cathepsin K is unique among mammalian proteinases

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Autocatalytic activation of human cathepsin K.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

The crystal structure of human procathepsin K

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Crystal structure of human cathepsin K complexed with a potent inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Crystal structure of human osteoclast cathepsin K complex with E-64

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Use of papain as a model for the structure-based design of cathepsin K inhibitors: crystal structures of two papain-inhibitor complexes demonstrate binding to S'-subsites

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Design of potent and selective human cathepsin K inhibitors that span the active site

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Structure-based design of cathepsin K inhibitors containing a benzyloxy-substituted benzoyl peptidomimetic

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

Population genomics: laying the groundwork for genetic disease modeling and targeting

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021

The Human Genome Project: from mapping to sequencing

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970056-0

7 January 2021