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CTLA-4 Overexpression Inhibits T Cell Responses through a CD28-B7-Dependent Mechanism

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CTLA-4 overexpression inhibits T cell responses through a CD28-B7-dependent mechanism

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CTLA-4 Overexpression Inhibits T Cell Responses through a CD28-B7-Dependent Mechanism (English)

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CTLA-4 overexpression inhibits T cell responses through a CD28-B7-dependent mechanism (English)

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James P Allison

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J. J. Engelhardt

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1

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T. J. Sullivan

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J. P. Allison

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3

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John J Engelhardt

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Timothy J Sullivan

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2

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English

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publication date

3 July 2006

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15 July 2006

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Journal of Immunology

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177

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2

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page(s)

1052-1061

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1052-61

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cites work

CTLA-4 can function as a negative regulator of T cell activation

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CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation

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Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses

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Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase

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Structure of murine CTLA-4 and its role in modulating T cell responsiveness

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B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

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Thymocyte development is normal in CTLA-4-deficient mice

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Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein

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B7-1 engagement of cytotoxic T lymphocyte antigen 4 inhibits T cell activation in the absence of CD28.

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B7-independent inhibition of T cells by CTLA-4.

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The lymphoproliferative defect in CTLA-4-deficient mice is ameliorated by an inhibitory NK cell receptor

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Re-establishing peripheral tolerance in the absence of CTLA-4: complementation by wild-type T cells points to an indirect role for CTLA-4

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CTLA-4 (CD152) can inhibit T cell activation by two different mechanisms depending on its level of cell surface expression

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Transgenic expression of CTLA-4 controls lymphoproliferation in IL-2-deficient mice

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Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation

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Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

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Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28.

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Interaction of the cytoplasmic tail of CTLA-4 (CD152) with a clathrin-associated protein is negatively regulated by tyrosine phosphorylation

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Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

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B7-1 and B7-2 selectively recruit CTLA-4 and CD28 to the immunological synapse

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CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2.

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CD28-mediated co-stimulation: a quantitative support for TCR signalling

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Opening a window on thymic positive selection: developmental changes in the influence of cosignaling by integrins and CD28 on selection events induced by TCR engagement

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Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells

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Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.

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Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation

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An essential role for Scurfin in CD4+CD25+ T regulatory cells

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Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2

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CD25(+)CD4(+) regulatory T cells exert in vitro suppressive activity independent of CTLA-4

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Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell function

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CTLA-4-Ig regulates tryptophan catabolism in vivo.

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Structural basis for co-stimulation by the human CTLA-4/B7-2 complex

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Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates primary and secondary peptide-specific CD4(+) T cell responses

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.177.2.1052

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

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10.4049/JIMMUNOL.177.2.1052

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16818761

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(Q56888824)

CTLA-4 Overexpression Inhibits T Cell Responses through a CD28-B7-Dependent Mechanism

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