(Q56900472)

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Detailed computational study of p53 and p16: using evolutionary sequence analysis and disease-associated mutations to predict the functional consequences of allelic variants

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scholarly article

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Detailed computational study of p53 and p16: using evolutionary sequence analysis and disease-associated mutations to predict the functional consequences of allelic variants (English)

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author name string

M S Greenblatt

1

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J G Beaudet

2

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J R Gump

3

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K S Godin

4

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L Trombley

5

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J Koh

6

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J P Bond

7

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publication date

27 February 2003

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22

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8

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1150-63

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Evolutionary parameters of the transcribed mammalian genome: an analysis of 2,820 orthologous rodent and human sequences

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Performance evaluation of amino acid substitution matrices

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Initial sequencing and analysis of the human genome

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Understanding human disease mutations through the use of interspecific genetic variation

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Compilation of somatic mutations of the CDKN2 gene in human cancers: non-random distribution of base substitutions

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Functional evaluation of tumour-specific variants of p16INK4a/CDKN2A: correlation with protein structure information.

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Evolutionary conservation and somatic mutation hotspot maps of p53: correlation with p53 protein structural and functional features.

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Functional reassessment of P16 variants using a transfection-based assay

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10.1038/SJ.ONC.1206101

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