(Q56970838)

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Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study

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Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study (English)

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object named as

Charles Mein

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Chris Wallace

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object named as

Mark Caulfield

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object named as

Richard Dobson

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Anna Dominiczak

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Anna Dominiczak

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Nilesh Samani

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object named as

G. Mark Lathrop

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Patricia B Munroe

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Patricia B. Munroe

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John Webster

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Martin Farrall

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Janine Pembroke

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Janine Pembroke

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author name string

Stephen J. Newhouse

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David Clayton

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Morris Brown

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John M. Connell

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publication date

11 May 2005

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Human Molecular Genetics

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14

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1805-1814

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13

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Trends in the prevalence of hypertension, antihypertensive therapy, and left ventricular hypertrophy from 1950 to 1989.

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Molecular mechanisms of human hypertension

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Syndrome of hypertension and hyperkalemia with normal glomerular filtration rate

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Pseudohypoaldosteronism type II: marked sensitivity to thiazides, hypercalciuria, normomagnesemia, and low bone mineral density

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WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II

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WNK kinases, a novel protein kinase subfamily in multi-cellular organisms

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Human hypertension caused by mutations in WNK kinases

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WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl- -transporting epithelia

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WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion

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Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4

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WNK kinases regulate thiazide-sensitive Na-Cl cotransport

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WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia

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Paracellular Cl- permeability is regulated by WNK4 kinase: insight into normal physiology and hypertension

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WNK kinases: molecular regulators of integrated epithelial ion transport

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Salt balance and long-term blood pressure control.

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Blood pressure control--special role of the kidneys and body fluids

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Identification of 108 SNPs in TSC, WNK1, and WNK4 and their association with hypertension in a Japanese general population

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Testing for linkage disequilibrium in genotypic data using the Expectation-Maximization algorithm

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The role of haplotypes in candidate gene studies

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Systolic blood pressure, diastolic blood pressure, and pulse pressure: an evaluation of their joint effect on mortality.

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Detecting disease associations due to linkage disequilibrium using haplotype tags: a class of tests and the determinants of statistical power.

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Choosing haplotype-tagging SNPS based on unphased genotype data using a preliminary sample of unrelated subjects with an example from the Multiethnic Cohort Study

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Tag SNP selection for association studies

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Regulation of WNK1 by an autoinhibitory domain and autophosphorylation

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Multiple promoters in the WNK1 gene: one controls expression of a kidney-specific kinase-defective isoform

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Wnk1 kinase deficiency lowers blood pressure in mice: A gene-trap screen to identify potential targets for therapeutic intervention

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Identifiers

10.1093/HMG/DDI187

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