Wikidata

(Q571999)

English

Inhibitor of nuclear factor kappa B kinase subunit beta

mammalian protein found in Homo sapiens

  • IKK2
  • IKK-B
  • IKBKB
  • NFKBIKB
  • I-kappa-B kinase 2
  • inhibitor of nuclear factor kappa-B kinase subunit beta
  • I-kappa-B-kinase beta
  • nuclear factor NF-kappa-B inhibitor kinase beta
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
In more languages

Statements

molecular function
protein binding
determination method
IPI
58 references
retrieved
1 January 2018
stated in
The zinc finger protein ZNF268 is overexpressed in human cervical cancer and contributes to tumorigenesis via enhancing NF-κB signaling
GOA
curator
UniProt
UniProt protein ID
O14920
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
IFIT5 positively regulates NF-κB signaling through synergizing the recruitment of IκB kinase (IKK) to TGF-β-activated kinase 1 (TAK1)
GOA
curator
UniProt
UniProt protein ID
O14920
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
TRIM40 promotes neddylation of IKKγ and is downregulated in gastrointestinal cancers
GOA
curator
UniProt
UniProt protein ID
O14920
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways
GOA
curator
UniProt
UniProt protein ID
O14920
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
LRRC14 attenuates Toll-like receptor-mediated NF-κB signaling through disruption of IKK complex
GOA
curator
UniProt
UniProt protein ID
O14920
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
Molecular mechanism of hTid-1, the human homolog of Drosophila tumor suppressor l(2)Tid, in the regulation of NF-kappaB activity and suppression of tumor growth
GOA
curator
UniProt
UniProt protein ID
O14920
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation
GOA
curator
UniProt
UniProt protein ID
O14920
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain
GOA
curator
UniProt
UniProt protein ID
O14920
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
Ro52-mediated monoubiquitination of IKK{beta} down-regulates NF-{kappa}B signalling
GOA
curator
UniProt
UniProt protein ID
O14920
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a
GOA
curator
UniProt
UniProt protein ID
O14920
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
Chaperone-mediated autophagy prevents apoptosis by degrading BBC3/PUMA
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
Binding of manumycin A inhibits IkappaB kinase beta activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
Functional role of c-Src in IL-1-induced NF-kappa B activation: c-Src is a component of the IKK complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
A Legionella type IV effector activates the NF-kappaB pathway by phosphorylating the IkappaB family of inhibitors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
The viral oncoprotein LMP1 exploits TRADD for signaling by masking its apoptotic activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
Positive regulation of IkappaB kinase signaling by protein serine/threonine phosphatase 2A
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in nuclear factor kappaB activation pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
Hepatitis B virus polymerase suppresses NF-κB signaling by inhibiting the activity of IKKs via interaction with Hsp90β
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
Modulation of TLR4 signaling by a novel adaptor protein signal-transducing adaptor protein-2 in macrophages
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
IKK{gamma} protein is a target of BAG3 regulatory activity in human tumor growth.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
Phosphorylation of CARMA1 by HPK1 is critical for NF-kappaB activation in T cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and Akt
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
Phosphorylation of p53 by IkappaB kinase 2 promotes its degradation by beta-TrCP.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
Crystal structure of inhibitor of κB kinase β
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
A role for IkappaB kinase 2 in bipolar spindle assembly
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
IKKβ phosphorylation regulates RPS3 nuclear translocation and NF-κB function during infection with Escherichia coli strain O157:H7
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
Theaflavins retard human breast cancer cell migration by inhibiting NF-kappaB via p53-ROS cross-talk.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
NESCA: a new NEMO/IKKgamma and TRAF6 interacting protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
The germinal center kinase TNIK is required for canonical NF-κB and JNK signaling in B-cells by the EBV oncoprotein LMP1 and the CD40 receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
Expanding the substantial interactome of NEMO using protein microarrays
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
Functional isoforms of IkappaB kinase alpha (IKKalpha) lacking leucine zipper and helix-loop-helix domains reveal that IKKalpha and IKKbeta have different activation requirements
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
Direct phosphorylation of NF-kappaB1 p105 by the IkappaB kinase complex on serine 927 is essential for signal-induced p105 proteolysis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
Viral immune modulators perturb the human molecular network by common and unique strategies
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
Inhibition of IkappaB kinase by vaccinia virus virulence factor B14
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
Theileria-induced constitutive IKK activation is independent of functional Hsp90
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
A cytoplasmic NF-κB interacting long noncoding RNA blocks IκB phosphorylation and suppresses breast cancer metastasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
retrieved
1 January 2018
stated in
A highly conserved proapoptotic gene, IKIP, located next to the APAF1 gene locus, is regulated by p53
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14920
determination method
IPI
cell component
biological process
Gene Atlas image
PBB GE IKBKB 209341 s at fs.png
732 × 530; 11 KB
0 references

Identifiers

RefSeq protein ID
Ensembl protein ID
 
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