(Q24337474)

GOA release 2020-03-11

1 reference

4

Curie Ahn

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author name string

Jeong-Eun Kim

1

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Dong-Joo You

2

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Cheolju Lee

3

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Jae Young Seong

5

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Jong-Ik Hwang

IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway

6

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language of work or name

English

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publication date

November 2010

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published in

Cellular Signalling

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volume

22

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issue

11

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page(s)

1645-54

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cites work

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GbetaL regulates TNFalpha-induced NF-kappaB signaling by directly inhibiting the activation of IkappaB kinase

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TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains

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Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer

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KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta

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IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a

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Development by self-digestion: molecular mechanisms and biological functions of autophagy

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Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

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Deactivation of the kinase IKK by CUEDC2 through recruitment of the phosphatase PP1.

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Integrating cell-signalling pathways with NF-kappaB and IKK function

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Dissection of the NF-kappaB signalling cascade in transgenic and knockout mice.

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Hsp90 inhibition results in autophagy-mediated proteasome-independent degradation of IkappaB kinase (IKK).

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Requirement of Hsp90 activity for IkappaB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-kappaB activation.

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IkappaB kinase complexes: gateways to NF-kappaB activation and transcription

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Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer

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Structure of the MTIP-MyoA complex, a key component of the malaria parasite invasion motor

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Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity

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Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

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The two-hybrid system: a method to identify and clone genes for proteins that interact with a protein of interest

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Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression

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The interaction of phospholipase C-beta3 with Shank2 regulates mGluR-mediated calcium signal

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PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex

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Signal responsiveness of IkappaB kinases is determined by Cdc37-assisted transient interaction with Hsp90.

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Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones

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7 January 2021

Signaling to NF-kappaB

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7 January 2021

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

1 reference

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7 January 2021

Activation of IkappaB kinase beta by protein kinase C isoforms

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7 January 2021

Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

1 reference

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7 January 2021

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

1 reference

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7 January 2021

Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth.

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Solubilization of aster-forming proteins from yeast: possible constituents of spindle pole body and reconstitution of asters in vitro

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Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells

1 reference

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7 January 2021