(Q57243643)

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MAPKAP kinase 2-deficiency prevents neurons from cell death by reducing neuroinflammation – relevance in a mouse model of Parkinson’s disease

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MAPKAP kinase 2-deficiency prevents neurons from cell death by reducing neuroinflammation – relevance in a mouse model of Parkinson’s disease (English)

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Parkinson's disease

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based on heuristic

inferred from title

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based on heuristic

inferred from title

Matthias Gaestel

object named as

Matthias Gaestel

6

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Alexey Kotlyarov

5

object named as

Alexey Kotlyarov

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author name string

Tobias Thomas

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Marco Timmer

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Konstantin Cesnulevicius

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Edward Hitti

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language of work or name

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publication date

June 2008

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Journal of Neurochemistry

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105

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2039-2052

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5

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Inhibition of p38 mitogen-activated protein kinase provides neuroprotection in cerebral focal ischemia

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p38 MAPK-mediated transcriptional activation of inducible nitric-oxide synthase in glial cells. Roles of nuclear factors, nuclear factor kappa B, cAMP response element-binding protein, CCAAT/enhancer-binding protein-beta, and activating transcriptio

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p38 MAP kinase mediates nitric oxide-induced apoptosis of neural progenitor cells.

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Phosphorylation of p38 MAPK induced by oxidative stress is linked to activation of both caspase-8- and -9-mediated apoptotic pathways in dopaminergic neurons

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Post-transcriptional regulation of gene expression by mitogen-activated protein kinase p38.

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MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity. Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease

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The involvement of AU-rich element-binding proteins in p38 mitogen-activated protein kinase pathway-mediated mRNA stabilisation.

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Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease

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Tristetraprolin regulates the expression of the human inducible nitric-oxide synthase gene

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Genetic ablation of tumor necrosis factor-alpha (TNF-alpha) and pharmacological inhibition of TNF-synthesis attenuates MPTP toxicity in mouse striatum

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CD14 mediate endotoxin induction of nitric oxide synthase in cultured brain glial cells

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p38 MAP kinase mediates bax translocation in nitric oxide-induced apoptosis in neurons

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An inhibitor of p38 and JNK MAP kinases prevents activation of caspase and apoptosis of cultured cerebellar granule neurons.

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Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element

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Regulatory roles of JNK in programmed cell death

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Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease

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MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis

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Distinct cellular functions of MK2.

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Minocycline inhibits apoptotic cell death via attenuation of TNF-alpha expression following iNOS/NO induction by lipopolysaccharide in neuron/glia co-cultures

1 reference

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Mitogen-activated protein kinase-activated protein kinase 2-deficient mice show increased susceptibility to Listeria monocytogenes infection

1 reference

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Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease

1 reference

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Inflammation in the CNS: balance between immunological privilege and immune responses.

1 reference

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MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels

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Etiology and pathogenesis of Parkinson's disease

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Activation of p38 and N-acetylcysteine-sensitive c-Jun NH2-terminal kinase signaling cascades is required for induction of apoptosis in Parkinson's disease cybrids

1 reference

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Total number of neurons in the neostriatal, pallidal, subthalamic, and substantia nigral nuclei of the rat basal ganglia: a stereological study using the cavalieri and optical disector methods

1 reference

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Critical role of ASK1 in the 6-hydroxydopamine-induced apoptosis in human neuroblastoma SH-SY5Y cells.

1 reference

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Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity

1 reference

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NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia.

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Complex contribution of the 3'-untranslated region to the expressional regulation of the human inducible nitric-oxide synthase gene. Involvement of the RNA-binding protein HuR.

1 reference

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A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1 reference

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Role of p38 and inducible nitric oxide synthase in the in vivo dopaminergic cells' degeneration induced by inflammatory processes after lipopolysaccharide injection.

1 reference

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Closed head injury triggers early production of TNF alpha and IL-6 by brain tissue.

1 reference

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P38 MAP kinase is activated at early stages in Alzheimer's disease brain.

1 reference

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Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration

1 reference

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Fibroblast growth factor (FGF)-2 and FGF receptor 3 are required for the development of the substantia nigra, and FGF-2 plays a crucial role for the rescue of dopaminergic neurons after 6-hydroxydopamine lesion

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Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds

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Analysis of properties of small heat shock protein Hsp25 in MAPK-activated protein kinase 2 (MK2)-deficient cells: MK2-dependent insolubilization of Hsp25 oligomers correlates with susceptibility to stress.

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Brain inflammation in epilepsy: experimental and clinical evidence

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Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

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Immunohistochemical localization of P-glycoprotein in rat brain and detection of its increased expression by seizures are sensitive to fixation and staining variables

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Mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 deficiency protects brain from ischemic injury in mice.

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Unbiased stereological estimation of the number of neurons in the human hippocampus.

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Identifiers

10.1111/J.1471-4159.2008.05310.X

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