(Q57274753)

English

Systematic knockdown of epigenetic enzymes identifies a novel histone demethylase PHF8 overexpressed in prostate cancer with an impact on cell proliferation, migration and invasion

scientific article published on 28 November 2011

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scholarly article

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17 January 2020

Systematic knockdown of epigenetic enzymes identifies a novel histone demethylase PHF8 overexpressed in prostate cancer with an impact on cell proliferation, migration and invasion (English)

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17 January 2020

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based on heuristic

inferred from title

prostate cancer

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based on heuristic

inferred from title

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based on heuristic

inferred from title

Päivi Östling

2

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17 January 2020

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17 January 2020

Tiina Vesterinen

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Olli-Pekka Kallioniemi

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17 January 2020

author name string

M Björkman

1

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17 January 2020

V Härmä

3

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17 January 2020

J Virtanen

4

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J-P Mpindi

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17 January 2020

J Rantala

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17 January 2020

M Lundin

9

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A Sankila

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17 January 2020

E Kaivanto

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17 January 2020

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publication date

28 November 2011

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17 January 2020

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17 January 2020

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17 January 2020

3444-3456

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17 January 2020

https://scigraph.springernature.com/pub.10.1038/onc.2011.512

0 references

IPCC flooded by criticism

1 reference

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21 January 2018

A novel mutation in the PHF8 gene is associated with X-linked mental retardation with cleft lip/cleft palate

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PHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks

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21 January 2018

Global levels of specific histone modifications and an epigenetic gene signature predict prostate cancer progression and development

1 reference

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Statistical methods for analysis of high-throughput RNA interference screens

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Defining the molecular action of HDAC inhibitors and synergism with androgen deprivation in ERG-positive prostate cancer

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Gene expression profiles of prostate cancer reveal involvement of multiple molecular pathways in the metastatic process

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21 January 2018

The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3

1 reference

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21 January 2018

Concepts of epigenetics in prostate cancer development

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beadarray: R classes and methods for Illumina bead-based data.

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Epigenetics in human disease and prospects for epigenetic therapy

1 reference

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Global levels of histone modifications predict prostate cancer recurrence.

1 reference

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21 January 2018

Epigenetics in cancer: targeting chromatin modifications

1 reference

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21 January 2018

Discovery and characterization of chromatin states for systematic annotation of the human genome

1 reference

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PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation

1 reference

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21 January 2018

Targeting monoamine oxidase A in advanced prostate cancer

1 reference

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21 January 2018

PHF8 targets histone methylation and RNA polymerase II to activate transcription.

1 reference

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21 January 2018

Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

1 reference

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21 January 2018

Integrin signalling during tumour progression

1 reference

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21 January 2018

Upregulation and nuclear recruitment of HDAC1 in hormone refractory prostate cancer.

1 reference

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21 January 2018

A comprehensive panel of three-dimensional models for studies of prostate cancer growth, invasion and drug responses

1 reference

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21 January 2018

Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases

1 reference

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21 January 2018

Identifying biological themes within lists of genes with EASE

1 reference

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21 January 2018

Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence

1 reference

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21 January 2018

Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues

1 reference

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21 January 2018

Screening of mutations in the PHF8 gene and identification of a novel mutation in a Finnish family with XLMR and cleft lip/cleft palate

1 reference

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21 January 2018

High mobility group protein B1 enhances DNA repair and chromatin modification after DNA damage

1 reference

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21 January 2018

Mutations in PHF8 are associated with X linked mental retardation and cleft lip/cleft palate

1 reference

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21 January 2018

Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications

1 reference

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21 January 2018

PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression

1 reference

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21 January 2018

PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase

1 reference

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21 January 2018

It takes a PHD to read the histone code

1 reference

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21 January 2018

LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription

1 reference

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21 January 2018

Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer

1 reference

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21 January 2018

Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development

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21 January 2018

Autism-associated familial microdeletion of Xp11.22

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Integrative functional genomics analysis of sustained polyploidy phenotypes in breast cancer cells identifies an oncogenic profile for GINS2

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A cell spot microarray method for production of high density siRNA transfection microarrays

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Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases

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21 January 2018

Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark

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21 January 2018

Global levels of histone modifications predict prognosis in different cancers

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21 January 2018

Global histone modification patterns predict risk of prostate cancer recurrence

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21 January 2018

Epigenetics in cancer

1 reference

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21 January 2018

Proteome-wide analysis in Saccharomyces cerevisiae identifies several PHD fingers as novel direct and selective binding modules of histone H3 methylated at either lysine 4 or lysine 36.

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Activation of androgen receptor by histone demethylases JMJD2A and JMJD2D.

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Succinate inhibition of alpha-ketoglutarate-dependent enzymes in a yeast model of paraganglioma

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Integrative genomic profiling of human prostate cancer

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PKCepsilon regulation of an alpha5 integrin-ZO-1 complex controls lamellae formation in migrating cancer cells.

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Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy

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Histone deacetylases are required for androgen receptor function in hormone-sensitive and castrate-resistant prostate cancer

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Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression

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A novel variant of the putative demethylase gene, s-JMJD1C, is a coactivator of the AR

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JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer

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JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor

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PHF8 is a histone H3K9me2 demethylase regulating rRNA synthesis.

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Project set to map marks on genome

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31 March 2020

Identifiers

10.1038/ONC.2011.512

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22120715%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

Europe PubMed Central

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17 January 2020

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