(Q57363820)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9807840%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

review article

1 reference

title

Signal-transduction cascades as targets for therapeutic intervention by natural products (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9807840%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

1 reference

4

Joseph Heitman

0 references

author name string

M E Cardenas

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9807840%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

A Sanfridson

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9807840%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

N S Cutler

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9807840%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

J Heitman

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9807840%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

publication date

1 October 1998

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9807840%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

published in

Trends in Biotechnology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9807840%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

volume

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9807840%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

page(s)

427-433

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9807840%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

issue

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9807840%20AND%20SRC:MED&resulttype=core&format=json

The mechanism of action of cyclosporin A and FK506

6 December 2019

cites work

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7 January 2021

Cyclosporin A, FK-506, and rapamycin: pharmacologic probes of lymphocyte signal transduction

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7 January 2021

Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex

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7 January 2021

X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex

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7 January 2021

Differential signaling by lymphocyte antigen receptors.

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7 January 2021

Transcription factors of the NFAT family: regulation and function

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7 January 2021

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

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7 January 2021

FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin

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7 January 2021

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

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7 January 2021

Calcineurin mediates inhibition by FK506 and cyclosporin of recovery from alpha-factor arrest in yeast

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7 January 2021

Calcineurin is essential in cyclosporin A- and FK506-sensitive yeast strains

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7 January 2021

Myristoylation of calcineurin B is not required for function or interaction with immunophilin-immunosuppressant complexes in the yeast Saccharomyces cerevisiae.

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7 January 2021

Calcineurin is required for virulence of Cryptococcus neoformans

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7 January 2021

Cryptococcosis in the era of AIDS--100 years after the discovery of Cryptococcus neoformans.

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7 January 2021

A signaling pathway to translational control

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7 January 2021

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

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7 January 2021

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

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7 January 2021

Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

1 reference

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7 January 2021

Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity

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7 January 2021

TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast

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7 January 2021

Golgi localization in yeast is mediated by the membrane anchor region of rat liver sialyltransferase

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7 January 2021

FKBP12-rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol-4 kinase activity.

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7 January 2021

TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin

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7 January 2021

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

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7 January 2021

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

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7 January 2021

Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

1 reference

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7 January 2021

RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex

1 reference

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7 January 2021

Mammalian RAFT1 kinase domain provides rapamycin-sensitive TOR function in yeast

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7 January 2021

The Rapamycin and FKBP12 Target (RAFT) Displays Phosphatidylinositol 4-Kinase Activity

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7 January 2021

Control of p70 s6 kinase by kinase activity of FRAP in vivo

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7 January 2021

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

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7 January 2021

Regulation of eIF-4E BP1 phosphorylation by mTOR.

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7 January 2021

Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: an alternative route to mitogen-induced gene expression

1 reference

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7 January 2021

4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase

1 reference

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7 January 2021

Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin

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7 January 2021

Rapamycin resistance tied to defective regulation of p27Kip1.

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7 January 2021

Effects of rapamycin on apoptosis of rheumatoid synovial cells

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7 January 2021

PI3K: downstream AKTion blocks apoptosis

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7 January 2021

Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase

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7 January 2021

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

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7 January 2021

Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

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7 January 2021

Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation

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7 January 2021

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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7 January 2021

Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase.

1 reference

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7 January 2021

Wortmannin inhibits the production of reactive oxygen and nitrogen intermediates and the killing of the Saccharomyces cerevisiae by isolated chicken macrophages

1 reference

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7 January 2021

A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein beta gamma subunits

1 reference

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7 January 2021

Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction

1 reference

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7 January 2021

Wortmannin inhibits mitogen-activated protein kinase activation by platelet-activating factor through a mechanism independent of p85/p110-type phosphatidylinositol 3-kinase

1 reference

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7 January 2021

Cloning and characterization of a wortmannin-sensitive human phosphatidylinositol 4-kinase

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7 January 2021

STT4 is an essential phosphatidylinositol 4-kinase that is a target of wortmannin in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2898%2901239-6

7 January 2021

DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2898%2901239-6

7 January 2021

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2898%2901239-6

7 January 2021

A comparison of demethoxyviridin and wortmannin as inhibitors of phosphatidylinositol 3-kinase.

1 reference

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7 January 2021

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2898%2901239-6

7 January 2021

Disruption of the Raf-1-Hsp90 molecular complex results in destabilization of Raf-1 and loss of Raf-1-Ras association

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2898%2901239-6

7 January 2021

Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

1 reference

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7 January 2021

A cyclophilin function in Hsp90-dependent signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0167-7799%2898%2901239-6

7 January 2021

10.1016/S0167-7799(98)01239-6

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9807840%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

1 reference