(Q57458023)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30327433%20AND%20SRC:MED&resulttype=core&format=json

29 April 2020

title

Discovery of the actinoplanic acid pathway in Streptomyces rapamycinicus reveals a genetically conserved synergism with rapamycin (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30327433%20AND%20SRC:MED&resulttype=core&format=json

Streptomyces hygroscopicus

29 April 2020

main subject

1 reference

inferred from

reverse claim

Streptomyces rapamycinicus

1 reference

inferred from

reverse claim

Streptomyces iranensis

1 reference

inferred from

reverse claim

2-(2-{[(6E,18E,22Z)-29-carboxy-12-[(3,4-dicarboxybutanoyl)oxy]-16-hydroxy-23,27-bis(hydroxymethyl)-5,15,17,19,21,29-hexamethyl-26-oxononacosa-6,18,22-trien-2-yl]oxy}-2-oxoethyl)butanedioic acid

1 reference

1 reference

1 reference

2-[2-[17-Amino-6-(3,4-dicarboxybutanoyloxy)-14,16-dihydroxy-5,9-dimethyloctadecan-7-yl]oxy-2-oxoethyl]butanedioic acid

1 reference

1 reference

2-(2-{[(6E)-11-[(14E,18Z)-4-carboxy-19-[6-carboxy-4-(hydroxymethyl)-6-methyl-3-oxohexyl]-12-hydroxy-11,13,15,17-tetramethyl-2,6-dioxo-1,7-dioxacycloicosa-14,18-dien-8-yl]-5-methylundec-6-en-2-yl]oxy}-2-oxoethyl)butanedioic acid

1 reference

1 reference

1 reference

2-[2-[17-Amino-6-(3,4-dicarboxybutanoyloxy)-14,16-dihydroxy-5,9-dimethylheptadecan-7-yl]oxy-2-oxoethyl]butanedioic acid

1 reference

Peter Mrak

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30327433%20AND%20SRC:MED&resulttype=core&format=json

29 April 2020

Philipp Krastel

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30327433%20AND%20SRC:MED&resulttype=core&format=json

29 April 2020

Petra Pivk Lukančič

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30327433%20AND%20SRC:MED&resulttype=core&format=json

29 April 2020

Jianshi Tao

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30327433%20AND%20SRC:MED&resulttype=core&format=json

29 April 2020

Dominik Pistorius

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30327433%20AND%20SRC:MED&resulttype=core&format=json

29 April 2020

Charles M Moore

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30327433%20AND%20SRC:MED&resulttype=core&format=json

29 April 2020

language of work or name

English

0 references

publication date

16 October 2018

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30327433%20AND%20SRC:MED&resulttype=core&format=json

full work available at URL

29 April 2020

http://www.jbc.org/article/S0021925820318718/pdf

1 reference

19 March 2024

https://api.unpaywall.org/v2/10.1074/jbc.ra118.005314?email=unpaywall_01@example.com

published in

Journal of Biological Chemistry

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30327433%20AND%20SRC:MED&resulttype=core&format=json

29 April 2020

volume

293

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30327433%20AND%20SRC:MED&resulttype=core&format=json

29 April 2020

issue

52

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30327433%20AND%20SRC:MED&resulttype=core&format=json

29 April 2020

page(s)

19982-19995

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30327433%20AND%20SRC:MED&resulttype=core&format=json

29 April 2020

1 reference

19 March 2024

https://api.unpaywall.org/v2/10.1074/jbc.ra118.005314?email=unpaywall_01@example.com

access restriction status

open access

1 reference

inferred from online access status

cites work

Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp.

1 reference

12 December 2020

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

1 reference

12 December 2020

Basic local alignment search tool

1 reference

12 December 2020

Actinoplanic acids A and B as novel inhibitors of farnesyl-protein transferase

1 reference

12 December 2020

Discovery, biosynthesis, and mechanism of action of the zaragozic acids: potent inhibitors of squalene synthase

1 reference

12 December 2020

A polyketide synthase gene required for biosynthesis of fumonisin mycotoxins in Gibberella fujikuroi mating population A.

1 reference

12 December 2020

A chain initiation factor common to both modular and aromatic polyketide synthases

1 reference

12 December 2020

Enhancement of the antifungal activity of rapamycin by the coproduced elaiophylin and nigericin

1 reference

12 December 2020

Jasmonic acid carboxyl methyltransferase: a key enzyme for jasmonate-regulated plant responses

1 reference

12 December 2020

AcnC of Escherichia coli is a 2-methylcitrate dehydratase (PrpD) that can use citrate and isocitrate as substrates

1 reference

12 December 2020

Co-expression of 15 contiguous genes delineates a fumonisin biosynthetic gene cluster in Gibberella moniliformis.

1 reference

12 December 2020

Synergy and contingency as driving forces for the evolution of multiple secondary metabolite production by Streptomyces species

1 reference

12 December 2020

High yield preparation of genomic DNA from Streptomyces.

1 reference

12 December 2020

MUSCLE: multiple sequence alignment with high accuracy and high throughput

1 reference

12 December 2020

The putative elaiophylin biosynthetic gene cluster in Streptomyces sp. DSM4137 is adjacent to genes encoding adenosylcobalamin-dependent methylmalonyl CoA mutase and to genes for synthesis of cobalamin

1 reference

12 December 2020

A bidomain nonribosomal peptide synthetase encoded by FUM14 catalyzes the formation of tricarballylic esters in the biosynthesis of fumonisins

1 reference

12 December 2020

Deletion analysis of FUM genes involved in tricarballylic ester formation during fumonisin biosynthesis.

1 reference

12 December 2020

Roles of rapH and rapG in positive regulation of rapamycin biosynthesis in Streptomyces hygroscopicus.

1 reference

12 December 2020

Five new members of the Streptomyces violaceusniger 16S rRNA gene clade: Streptomyces castelarensis sp. nov., comb. nov., Streptomyces himastatinicus sp. nov., Streptomyces mordarskii sp. nov., Streptomyces rapamycinicus sp. nov. and Streptomyces ru

1 reference

12 December 2020

RAS: target for cancer therapy

1 reference

12 December 2020

Network pharmacology: the next paradigm in drug discovery

1 reference

12 December 2020

Analysis of functions in plasmid pHZ1358 influencing its genetic and structural stability in Streptomyces lividans 1326.

1 reference

12 December 2020

A small G protein Rhb1 and a GTPase-activating protein Tsc2 involved in nitrogen starvation-induced morphogenesis and cell wall integrity of Candida albicans

1 reference

12 December 2020

Diversity in enoyl-acyl carrier protein reductases

1 reference

12 December 2020

A PLP-dependent polyketide chain releasing mechanism in the biosynthesis of mycotoxin fumonisins in Fusarium verticillioides

1 reference

12 December 2020

A free-standing condensation enzyme catalyzing ester bond formation in C-1027 biosynthesis

1 reference

12 December 2020

PKS and NRPS release mechanisms

1 reference

12 December 2020

Prodigal: prokaryotic gene recognition and translation initiation site identification

1 reference

12 December 2020

FastTree 2--approximately maximum-likelihood trees for large alignments

1 reference

12 December 2020

The farnesyl transferase inhibitor lonafarnib inhibits mTOR signaling and enforces sorafenib-induced apoptosis in melanoma cells

1 reference

12 December 2020

Isolation and structure of homotemsirolimuses A, B, and C.

1 reference

12 December 2020

CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III

1 reference

12 December 2020

Synergistic drug combinations for tuberculosis therapy identified by a novel high-throughput screen

1 reference

12 December 2020

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

1 reference

12 December 2020

Evolution of the TOR pathway

1 reference

12 December 2020

Novel chemobiosynthetic approach for exclusive production of FK506.

1 reference

12 December 2020

Regulation of TOR by small GTPases

1 reference

12 December 2020

Structure and noncanonical chemistry of nonribosomal peptide biosynthetic machinery

1 reference

12 December 2020

S-adenosyl-methionine-dependent methyltransferases: highly versatile enzymes in biocatalysis, biosynthesis and other biotechnological applications.

1 reference

12 December 2020

Clavulanic acid production by Streptomyces clavuligerus: biogenesis, regulation and strain improvement

1 reference

12 December 2020

Synthetic riboswitches for the conditional control of gene expression in Streptomyces coelicolor.

1 reference

12 December 2020

Design, construction and characterisation of a synthetic promoter library for fine-tuned gene expression in actinomycetes

1 reference

12 December 2020

Draft Genome Sequence of Streptomyces rapamycinicus Strain NRRL 5491, the Producer of the Immunosuppressant Rapamycin

1 reference

12 December 2020

Farnesyltransferase inhibitors: a comprehensive review based on quantitative structural analysis.

1 reference

12 December 2020

Genome engineering using the CRISPR-Cas9 system

1 reference

12 December 2020

Tricarballylic ester formation during biosynthesis of fumonisin mycotoxins in Fusarium verticillioides

1 reference

12 December 2020

Draft Genome Sequence of Streptomyces iranensis.

1 reference

12 December 2020

An analysis of FDA-approved drugs: natural products and their derivatives.

1 reference

12 December 2020

Comparative analysis of rapamycin biosynthesis clusters between Actinoplanes sp. N902-109 and Streptomyces hygroscopicus ATCC29253

1 reference

12 December 2020

antiSMASH 3.0-a comprehensive resource for the genome mining of biosynthetic gene clusters

1 reference

12 December 2020

High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations

1 reference

12 December 2020

Roles of the crotonyl-CoA carboxylase/reductase homologues in acetate assimilation and biosynthesis of immunosuppressant FK506 in Streptomyces tsukubaensis.

1 reference

12 December 2020

Biochemical Studies of Mycobacterial Fatty Acid Methyltransferase: A Catalyst for the Enzymatic Production of Biodiesel

1 reference

12 December 2020

Harnessing natural product assembly lines: structure, promiscuity, and engineering

1 reference

12 December 2020

Natural product discovery: past, present, and future

1 reference

12 December 2020

TORC2 Structure and Function

1 reference

12 December 2020

The small GTPases Ras and Rap1 bind to and control TORC2 activity

1 reference

12 December 2020

The evolution of genome mining in microbes - a review.

1 reference

12 December 2020

An overview of rapamycin: from discovery to future perspectives

1 reference

12 December 2020

Retrospective analysis of natural products provides insights for future discovery trends

1 reference

12 December 2020

Structural and functional aspects of the nonribosomal peptide synthetase condensation domain superfamily: discovery, dissection and diversity

1 reference

12 December 2020

High-throughput identification and rational design of synergistic small-molecule pairs for combating and bypassing antibiotic resistance

1 reference

12 December 2020

The TOR Signaling Pathway in Spatial and Temporal Control of Cell Size and Growth

1 reference

12 December 2020

Evolutionary Conservation of the Components in the TOR Signaling Pathways

1 reference

12 December 2020

The Candida albicans TOR-Activating GTPases Gtr1 and Rhb1 Coregulate Starvation Responses and Biofilm Formation

1 reference

12 December 2020

Structural Insights into the Free-Standing Condensation Enzyme SgcC5 Catalyzing Ester-Bond Formation in the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027.

1 reference

12 December 2020

Synergistic activity of cosecreted natural products from amoebae-associated bacteria.

1 reference

12 December 2020

New tricks for human farnesyltransferase inhibitor: cancer and beyond

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.RA118.005314

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30327433%20AND%20SRC:MED&resulttype=core&format=json

29 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30327433%20AND%20SRC:MED&resulttype=core&format=json

29 April 2020

PubMed publication ID

30327433

1 reference