(Q57562833)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10791951%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

title

Inhibition of the phosphoinositide 3-kinase pathway induces a senescence-like arrest mediated by p27Kip1 (English)

1 reference

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6 November 2019

1

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6 November 2019

René H. Medema

2

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6 November 2019

Carmen Rivas

7

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6 November 2019

Manuel Serrano

9

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6 November 2019

Eric W-F Lam

10

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6 November 2019

author name string

I Garcia-Cao

3

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6 November 2019

M L Dubuisson

4

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6 November 2019

M Barradas

5

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6 November 2019

J Glassford

6

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6 November 2019

B M Burgering

8

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6 November 2019

language of work or name

English

0 references

publication date

1 July 2000

1 reference

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Journal of Biological Chemistry

6 November 2019

published in

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6 November 2019

volume

275

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6 November 2019

issue

29

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6 November 2019

page(s)

21960-21968

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The serial cultivation of human diploid cell strains

6 November 2019

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Increased activity of p53 in senescing fibroblasts

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Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence

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A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

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p21 is a universal inhibitor of cyclin kinases

21 January 2018

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21 January 2018

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WAF1, a potential mediator of p53 tumor suppression

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Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts

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Senescent cells fail to express cdc2, cycA, and cycB in response to mitogen stimulation

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Regulation of dihydrofolate reductase gene expression and E2F components in human diploid fibroblasts during growth and senescence

21 January 2018

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The retinoblastoma protein and cell cycle control

21 January 2018

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Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF.

21 January 2018

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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

21 January 2018

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Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

21 January 2018

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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

21 January 2018

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ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

21 January 2018

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Inhibition of ras-induced proliferation and cellular transformation by p16INK4.

21 January 2018

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p19ARF links the tumour suppressor p53 to Ras

21 January 2018

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Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap

21 January 2018

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Phosphatidylinositol-3-OH kinase as a direct target of Ras

21 January 2018

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Complex formation between RAS and RAF and other protein kinases

21 January 2018

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Senescence of human fibroblasts induced by oncogenic Raf.

21 January 2018

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Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

21 January 2018

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Using structure to define the function of phosphoinositide 3-kinase family members

21 January 2018

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Signalling through phosphoinositide 3-kinases: the lipids take centre stage

21 January 2018

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Molecular genetics of life span in C. elegans: how much does it teach us?

21 January 2018

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Role of the INK4a locus in tumor suppression and cell mortality.

21 January 2018

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21 January 2018

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A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

21 January 2018

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21 January 2018

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

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21 January 2018

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AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

21 January 2018

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Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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p130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activity

21 January 2018

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A function for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in fibroblasts during mitogenesis: requirement for insulin- and lysophosphatidic acid-mediated signal transduction

21 January 2018

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The phosphatidylinositol 3-kinase alpha is required for DNA synthesis induced by some, but not all, growth factors

21 January 2018

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Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts

21 January 2018

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PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells

21 January 2018

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Cloning and characterization of a wortmannin-sensitive human phosphatidylinositol 4-kinase

21 January 2018

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Isolation and molecular cloning of wortmannin-sensitive bovine type III phosphatidylinositol 4-kinases.

21 January 2018

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Cloning and characterization of a 92 kDa soluble phosphatidylinositol 4-kinase

21 January 2018

1 reference

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Characterization of a soluble adrenal phosphatidylinositol 4-kinase reveals wortmannin sensitivity of type III phosphatidylinositol kinases.

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M000759200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10791951%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

1 reference