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Different Effects of SLCO1B1 Polymorphism on the Pharmacokinetics of Atorvastatin and Rosuvastatin
scientific article published on 02 May 2007
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Europe PubMed Central
PubMed publication ID
17473846
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17473846%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
title
Different effects of SLCO1B1 polymorphism on the pharmacokinetics of atorvastatin and rosuvastatin
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17473846
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17473846%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
main subject
pharmacokinetics
1 reference
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inferred from title
author
Pertti J. Neuvonen
series ordinal
3
1 reference
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Europe PubMed Central
PubMed publication ID
17473846
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17473846%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
Mikko Niemi
series ordinal
4
1 reference
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Europe PubMed Central
PubMed publication ID
17473846
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17473846%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
author name string
M K Pasanen
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17473846
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17473846%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
H Fredrikson
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17473846
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17473846%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
language of work or name
English
0 references
publication date
2 May 2007
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17473846
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17473846%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
published in
Clinical Pharmacology & Therapeutics
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17473846
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17473846%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
volume
82
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17473846
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17473846%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
issue
6
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17473846
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17473846%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
page(s)
726-733
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17473846
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17473846%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
cites work
Grapefruit juice increases serum concentrations of atorvastatin and has no effect on pravastatin
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Statin-associated myopathy
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Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance
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A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters
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Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans
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Crossref
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7 January 2021
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Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B1*5, SLCO1B1*15 and SLCO1B1*15+C1007G, by using transient expression systems of HeLa and HEK293 cells
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Human hepatobiliary transport of organic anions analyzed by quadruple-transfected cells
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Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics.
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Transporters and drug therapy: implications for drug disposition and disease
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Crossref
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7 January 2021
based on heuristic
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Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100220
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7 January 2021
based on heuristic
inferred from DOI database lookup
Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100220
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7 January 2021
based on heuristic
inferred from DOI database lookup
Evidence for inverse effects of OATP-C (SLC21A6) 5 and 1b haplotypes on pravastatin kinetics
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100220
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100220
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7 January 2021
based on heuristic
inferred from DOI database lookup
Rosuvastatin pharmacokinetics and pharmacogenetics in white and Asian subjects residing in the same environment
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100220
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7 January 2021
based on heuristic
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Effect of OATP1B1 (SLCO1B1) variant alleles on the pharmacokinetics of pitavastatin in healthy volunteers.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100220
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7 January 2021
based on heuristic
inferred from DOI database lookup
SLCO1B1 polymorphism and sex affect the pharmacokinetics of pravastatin but not fluvastatin
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100220
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7 January 2021
based on heuristic
inferred from DOI database lookup
SLCO1B1 polymorphism markedly affects the pharmacokinetics of simvastatin acid
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100220
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7 January 2021
based on heuristic
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Clinical Pharmacokinetics of Atorvastatin
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Crossref
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https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100220
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7 January 2021
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The interconversion kinetics, equilibrium, and solubilities of the lactone and hydroxyacid forms of the HMG-CoA reductase inhibitor, CI-981
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7 January 2021
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Glucuronidation of statins in animals and humans: a novel mechanism of statin lactonization
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https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100220
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7 January 2021
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Atorvastatin transport in the Caco-2 cell model: contributions of P-glycoprotein and the proton-monocarboxylic acid co-transporter
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100220
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7 January 2021
based on heuristic
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Involvement of BCRP (ABCG2) in the biliary excretion of pitavastatin
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100220
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7 January 2021
based on heuristic
inferred from DOI database lookup
Organic anion transporting polypeptide 2B1 is a high-affinity transporter for atorvastatin and is expressed in the human heart
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100220
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7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of itraconazole on the pharmacokinetics of atorvastatin
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100220
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7 January 2021
based on heuristic
inferred from DOI database lookup
Rifampin markedly decreases and gemfibrozil increases the plasma concentrations of atorvastatin and its metabolites
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100220
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7 January 2021
based on heuristic
inferred from DOI database lookup
Substantially elevated levels of atorvastatin and metabolites in cyclosporine-treated renal transplant recipients
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100220
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7 January 2021
based on heuristic
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Pharmacokinetic interactions with rifampicin : clinical relevance
1 reference
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https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100220
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7 January 2021
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Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes.
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100220
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7 January 2021
based on heuristic
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effect of OATP1B transporter inhibition on the pharmacokinetics of atorvastatin in healthy volunteers
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100220
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7 January 2021
based on heuristic
inferred from DOI database lookup
Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100220
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7 January 2021
based on heuristic
inferred from DOI database lookup
Preclinical and clinical pharmacology of Rosuvastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100220
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7 January 2021
based on heuristic
inferred from DOI database lookup
Metabolism, excretion, and pharmacokinetics of rosuvastatin in healthy adult male volunteers
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100220
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7 January 2021
based on heuristic
inferred from DOI database lookup
Rosuvastatin pharmacokinetics in heart transplant recipients administered an antirejection regimen including cyclosporine
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100220
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7 January 2021
based on heuristic
inferred from DOI database lookup
The effect of gemfibrozil on the pharmacokinetics of rosuvastatin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100220
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of itraconazole on the pharmacokinetics of rosuvastatin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100220
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Polymorphic organic anion transporting polypeptide 1B1 is a major determinant of repaglinide pharmacokinetics
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100220
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7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of transporter-mediated hepatic uptake as a mechanism for drug-drug interaction between cerivastatin and cyclosporin A.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100220
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Contributions of hepatic and intestinal metabolism and P-glycoprotein to cyclosporine and tacrolimus oral drug delivery
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100220
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cyclosporine markedly raises the plasma concentrations of repaglinide
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100220
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100220
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The human hepatic metabolism of simvastatin hydroxy acid is mediated primarily by CYP3A, and not CYP2D6.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100220
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) and genetic variability (single nucleotide polymorphisms) in a hepatic drug uptake transporter: what's it all about?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100220
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of genetic polymorphism of OATP-C (SLCO1B1) on lipid-lowering response to HMG-CoA reductase inhibitors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100220
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Acute effects of pravastatin on cholesterol synthesis are associated with SLCO1B1 (encoding OATP1B1) haplotype *17.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100220
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Impact of the SLCO1B1 polymorphism on the pharmacokinetics and lipid-lowering efficacy of multiple-dose pravastatin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100220
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Exposure of atorvastatin is unchanged but lactone and acid metabolites are increased several-fold in patients with atorvastatin-induced myopathy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100220
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Frequencies of single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide 1B1 SLCO1B1 gene in a Finnish population
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100220
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Lipid-lowering response to statins is affected by CYP3A5 polymorphism
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100220
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Quantitation of the acid and lactone forms of atorvastatin and its biotransformation products in human serum by high-performance liquid chromatography with electrospray tandem mass spectrometry
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100220
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Determination of atorvastatin and metabolites in human plasma with solid-phase extraction followed by LC-tandem MS.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100220
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/SJ.CLPT.6100220
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17473846
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17473846%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
Dimensions Publication ID
1053382508
0 references
PubMed publication ID
17473846
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17473846
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17473846%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 December 2019
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