(Q57828802)

12 December 2020

Peptide inhibitors of beta amyloid aggregation

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12 December 2020

An orientation-dependent hydrogen bonding potential improves prediction of specificity and structure for proteins and protein-protein complexes.

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12 December 2020

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

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12 December 2020

Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B

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12 December 2020

Assessing the performance of OMEGA with respect to retrieving bioactive conformations

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12 December 2020

DOCK 4.0: Search strategies for automated molecular docking of flexible molecule databases

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12 December 2020

Molecular basis for amyloid- polymorphism

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12 December 2020

Small-molecule conversion of toxic oligomers to nontoxic β-sheet-rich amyloid fibrils

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12 December 2020

Atomic View of a Toxic Amyloid Small Oligomer

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12 December 2020

The amyloid state of proteins in human diseases

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12 December 2020

Microcin amyloid fibrils A are reservoir of toxic oligomeric species

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12 December 2020

Phenolic compounds prevent amyloid β-protein oligomerization and synaptic dysfunction by site-specific binding

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12 December 2020

Direct observation of the interconversion of normal and toxic forms of α-synuclein

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12 December 2020

Conserved features of intermediates in amyloid assembly determine their benign or toxic states

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12 December 2020

Inhibition of amyloid formation

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12 December 2020

Discovery and structure activity relationship of small molecule inhibitors of toxic β-amyloid-42 fibril formation

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12 December 2020

Amyloid β-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity

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12 December 2020

Rational design of potent domain antibody inhibitors of amyloid fibril assembly

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12 December 2020

Out-of-register -sheets suggest a pathway to toxic amyloid aggregates

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12 December 2020

Shape complementarity at protein/protein interfaces

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12 December 2020

Selective inhibition of Abeta fibril formation

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12 December 2020

Effective energy function for proteins in solution

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12 December 2020

Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.

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12 December 2020

Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

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12 December 2020

Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils

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12 December 2020

ZINC--a free database of commercially available compounds for virtual screening

1 reference

12 December 2020

Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo

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12 December 2020

Structural properties of Abeta protofibrils stabilized by a small molecule.

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12 December 2020

Structure of the cross-beta spine of amyloid-like fibrils

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12 December 2020

The most infectious prion protein particles.

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12 December 2020

3D structure of Alzheimer's amyloid-beta(1-42) fibrils

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12 December 2020

Experimental constraints on quaternary structure in Alzheimer's beta-amyloid fibrils

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12 December 2020

Inhibition of amyloid fibril formation by polyphenols: structural similarity and aromatic interactions as a common inhibition mechanism

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12 December 2020

The Blue Obelisk-interoperability in chemical informatics

1 reference

12 December 2020

Protein misfolding, functional amyloid, and human disease

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12 December 2020

Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model.

1 reference

12 December 2020

N-Methylated peptide inhibitors of beta-amyloid aggregation and toxicity. Optimization of the inhibitor structure

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12 December 2020

Heat shock proteins 70 and 90 inhibit early stages of amyloid beta-(1-42) aggregation in vitro.

1 reference

12 December 2020

ROSETTALIGAND: protein-small molecule docking with full side-chain flexibility.

1 reference

12 December 2020

Congo red and protein aggregation in neurodegenerative diseases

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12 December 2020

Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct

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12 December 2020

Atomic structures of amyloid cross-beta spines reveal varied steric zippers

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12 December 2020

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

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12 December 2020

Peptide and protein mimetics inhibiting amyloid beta-peptide aggregation.

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12 December 2020

RosettaLigand docking with full ligand and receptor flexibility.

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12 December 2020

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

1 reference

12 December 2020

Fibril fragmentation enhances amyloid cytotoxicity

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12 December 2020

The recombinant amyloid-beta peptide Abeta1-42 aggregates faster and is more neurotoxic than synthetic Abeta1-42.

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12 December 2020

Amyloid-beta fibrillogenesis: structural insight and therapeutic intervention

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12 December 2020

Strategies for the inhibition of protein aggregation in human diseases

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12 December 2020

Small molecule microarrays enable the discovery of compounds that bind the Alzheimer's Aβ peptide and reduce its cytotoxicity

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12 December 2020

ROSETTA3: an object-oriented software suite for the simulation and design of macromolecules

1 reference

12 December 2020

Aromatic small molecules remodel toxic soluble oligomers of amyloid beta through three independent pathways

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12 December 2020

Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan

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12 December 2020

The amyloid-Congo red interface at atomic resolution

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12 December 2020

Towards a Pharmacophore for Amyloid

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12 December 2020

Native protein sequences are close to optimal for their structures

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12 December 2020

Inhibition of Alzheimer's disease beta-amyloid aggregation, neurotoxicity, and in vivo deposition by nitrophenols: implications for Alzheimer's therapy.

1 reference

12 December 2020