(Q39439924)

12 September 2017

title

Small-molecule conversion of toxic oligomers to nontoxic β-sheet-rich amyloid fibrils (English)

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12 September 2017

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20

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12 September 2017

Thomas Wiglenda

3

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Björn A Grüning

object named as

Björn A Grüning

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Sigrid Schnoegl

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object named as

Sigrid Schnoegl

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12 September 2017

1

Jan Bieschke

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5

Annett Boeddrich

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12

Rudi Lurz

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Martin Herbst

2

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Ralf P Friedrich

4

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Franziska Schiele

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Daniela Kleckers

7

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Juan Miguel Lopez del Amo

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Qinwen Wang

10

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Michael R Schmidt

11

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Roger Anwyl

13

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Marcus Fändrich

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Ronald F Frank

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Stefan Günther

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Dominic M Walsh

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12 September 2017

publication date

20 November 2011

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12 September 2017

published in

Nature Chemical Biology

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12 September 2017

volume

8

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12 September 2017

issue

1

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12 September 2017

page(s)

93-101

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Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates

12 September 2017

cites work

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12 December 2020

Anti-amyloidogenic therapies: strategies for prevention and treatment of Alzheimer's disease

1 reference

12 December 2020

Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models

1 reference

12 December 2020

Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes

1 reference

12 December 2020

Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models.

1 reference

12 December 2020

High-resolution atomic force microscopy of soluble Abeta42 oligomers

1 reference

12 December 2020

Aggregated polyglutamine peptides delivered to nuclei are toxic to mammalian cells

1 reference

12 December 2020

Structural properties of Abeta protofibrils stabilized by a small molecule.

1 reference

12 December 2020

Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct

1 reference

12 December 2020

A beta oligomers - a decade of discovery

1 reference

12 December 2020

Generic hydrophobic residues are sufficient to promote aggregation of the Alzheimer's Abeta42 peptide

1 reference

12 December 2020

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

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12 December 2020

Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill

1 reference

12 December 2020

Antibodies against beta-amyloid reduce Abeta oligomers, glycogen synthase kinase-3beta activation and tau phosphorylation in vivo and in vitro.

1 reference

12 December 2020

[18] Quantification of β-sheet amyloid fibril structures with thioflavin T

1 reference

12 December 2020

3D structure of Alzheimer's amyloid-beta(1-42) fibrils

1 reference

12 December 2020

Inositol stereoisomers stabilize an oligomeric aggregate of Alzheimer amyloid beta peptide and inhibit abeta -induced toxicity.

1 reference

12 December 2020

Large-scale analysis of protein-protein interactions using cellulose-bound peptide arrays

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12 December 2020

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

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12 December 2020

Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct

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12 December 2020

Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

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12 December 2020

Small-molecule aggregates inhibit amyloid polymerization

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12 December 2020

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers

1 reference

12 December 2020

EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity.

1 reference

12 December 2020

Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by using an automated filter retardation assay

1 reference

12 December 2020

Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution

1 reference

12 December 2020

Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model.

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12 December 2020

Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Abeta protofibrils

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12 December 2020

Manipulating the amyloid-beta aggregation pathway with chemical chaperones.

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12 December 2020

Models of amyloid seeding in Alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins

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12 December 2020

Inhibition of beta-amyloid-induced neurotoxicity by imidazopyridoindoles derived from a synthetic combinatorial library

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12 December 2020

A strategy for designing inhibitors of beta-amyloid toxicity

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12 December 2020

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

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12 December 2020

Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy

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12 December 2020

Therapeutic approaches to polyglutamine diseases: combating protein misfolding and aggregation.

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12 December 2020

Amyloid-like properties of a synthetic peptide corresponding to the carboxy terminus of beta-amyloid protein precursor.

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12 December 2020

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12 December 2020

Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils

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12 December 2020

Inhibition of fibril formation in beta-amyloid peptide by a novel series of benzofurans

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12 December 2020

Resveratrol selectively remodels soluble oligomers and fibrils of amyloid Abeta into off-pathway conformers

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12 December 2020

Role of amyloid-beta glycine 33 in oligomerization, toxicity, and neuronal plasticity

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12 December 2020

Evidence of fibril-like β-sheet structures in a neurotoxic amyloid intermediate of Alzheimer's β-amyloid.

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12 December 2020

The challenge of inhibiting Abeta polymerization

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12 December 2020

Specific detection of quinoproteins by redox-cycling staining

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12 December 2020

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

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12 December 2020

Rifampicin prevents the aggregation and neurotoxicity of amyloid beta protein in vitro.

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12 December 2020

Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as

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12 December 2020

Recognition sequence design for peptidyl modulators of beta-amyloid aggregation and toxicity.

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12 December 2020

Identifiers

DOI

10.1038/NCHEMBIO.719

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Dimensions Publication ID

12 September 2017

1006610350

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