(Q79851539)

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Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as

scientific article published on 01 March 2004

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26 December 2019

Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as well as metabotropic glutamate receptor type 5 (English)

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26 December 2019

long-term potentiation

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Michael J Rowan

3

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26 December 2019

Dennis J. Selkoe

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Dennis J Selkoe

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26 December 2019

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Qinwen Wang

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26 December 2019

Dominic M Walsh

2

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26 December 2019

Roger Anwyl

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26 December 2019

publication date

1 March 2004

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26 December 2019

Journal of Neuroscience

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26 December 2019

24

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26 December 2019

13

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26 December 2019

3370-3378

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26 December 2019

Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p38 kinase is activated in the Alzheimer's disease brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mitogen-activated protein kinase cascade couples PKA and PKC to cAMP response element binding protein phosphorylation in area CA1 of hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of tau phosphorylating protein kinase cdk5 prevents beta-amyloid-induced neuronal death

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impairments of long-term potentiation in hippocampal slices of beta-amyloid-infused rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ERK plays a regulatory role in induction of LTP by theta frequency stimulation and its modulation by beta-adrenergic receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The p38 signal transduction pathway: activation and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-amyloid stimulation of inducible nitric-oxide synthase in astrocytes is interleukin-1beta- and tumor necrosis factor-alpha (TNFalpha)-dependent, and involves a TNFalpha receptor-associated factor- and NFkappaB-inducing kinase-dependent signalin

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impairment of hippocampal long-term potentiation by Alzheimer amyloid beta-peptides

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotoxicity induces cleavage of p35 to p25 by calpain

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coactivation of beta-adrenergic and cholinergic receptors enhances the induction of long-term potentiation and synergistically activates mitogen-activated protein kinase in the hippocampal CA1 region.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective blockade of metabotropic glutamate receptor subtype 5 is neuroprotective

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dual roles for c-Jun N-terminal kinase in developmental and stress responses in cerebellar granule neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dual MAP kinase pathways mediate opposing forms of long-term plasticity at CA3–CA1 synapses

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

JNK activation is associated with intracellular beta-amyloid accumulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Abeta-induced cortical neuron apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation of aggregated beta-amyloid in the rat hippocampus impairs synaptic transmission and plasticity and causes memory deficits

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease and Abeta toxicity: from top to bottom

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of cyclin-dependent kinase 5 and casein kinase 1 by metabotropic glutamate receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A decade of CDK5.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of MKK6, an upstream activator of p38, in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of amyloid-beta at the serine 26 residue by human cdc2 kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of the critical features of a small peptide inhibitor of JNK activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of c-Jun N-terminal kinase and p38 in an Alzheimer's disease model is associated with amyloid deposition.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta -Amyloid peptide activates alpha 7 nicotinic acetylcholine receptors expressed in Xenopus oocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Innate immunity: the missing link in neuroprotection and neurodegeneration?

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of membrane depolarization caused by the Alzheimer Abeta1-42 peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Group I metabotropic glutamate receptor (mGluR)-dependent long-term depression mediated via p38 mitogen-activated protein kinase is inhibited by previous high-frequency stimulation and activation of mGluRs and protein kinase C in the rat dentate gyr

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological inhibitors of cyclin-dependent kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta -peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease is a synaptic failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A role for ERK MAP kinase in physiologic temporal integration in hippocampal area CA1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elements of a neurobiological theory of the hippocampus: the role of activity-dependent synaptic plasticity in memory

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amnestic effects in mice of four synthetic peptides homologous to amyloid beta protein from patients with Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased immunoreactivity for Jun- and Fos-related proteins in Alzheimer's disease: association with pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA damage and apoptosis in Alzheimer's disease: colocalization with c-Jun immunoreactivity, relationship to brain area, and effect of postmortem delay.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amnesia induced in mice by centrally administered beta-amyloid peptides involves cholinergic dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aggregated amyloid-beta protein induces cortical neuronal apoptosis and concomitant "apoptotic" pattern of gene induction.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Block of LTP in rat hippocampus in vivo by beta-amyloid precursor protein fragments

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stress-activated protein kinases: activation, regulation and function.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitogen-activated protein kinases activated by lipopolysaccharide and beta-amyloid in cultured rat microglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid fibrils activate parallel mitogen-activated protein kinase pathways in microglia and THP1 monocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15056716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.1633-03.2004

1 reference

Europe PubMed Central

PMC publication ID

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26 December 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15056716%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15056716%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

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