(Q34743288)

4 August 2017

1 reference

title

Therapeutic strategies for human amyloid diseases (English)

1 reference

4 August 2017

2

Jeffery W Kelly

1 reference

4 August 2017

James C Sacchettini

1

1 reference

4 August 2017

1 April 2002

1 reference

Nature Reviews Drug Discovery

4 August 2017

1 reference

4 August 2017

1

1 reference

4 August 2017

267-275

1 reference

4 August 2017

4

1 reference

https://scigraph.springernature.com/pub.10.1038/nrd769

4 August 2017

0 references

cites work

Immunoglobulin light chains, glycosaminoglycans, and amyloid.

1 reference

Alternative conformations of amyloidogenic proteins govern their behavior

21 January 2018

1 reference

Protein aggregation: folding aggregates, inclusion bodies and amyloid

21 January 2018

1 reference

Serum amyloid A: from fibril to function. Current status

21 January 2018

1 reference

Human lysozyme gene mutations cause hereditary systemic amyloidosis

21 January 2018

1 reference

Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

21 January 2018

1 reference

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

21 January 2018

1 reference

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

Furin initiates gelsolin familial amyloidosis in the Golgi through a defect in Ca(2+) stabilization

21 January 2018

1 reference

A new frontier in pharmacology: the endoplasmic reticulum as a regulated export pathway in health and disease

21 January 2018

1 reference

Amyloid fibril formation and protein misassembly: a structural quest for insights into amyloid and prion diseases

21 January 2018

1 reference

The environmental dependency of protein folding best explains prion and amyloid diseases

21 January 2018

1 reference

Fibril in senile systemic amyloidosis is derived from normal transthyretin

21 January 2018

1 reference

Amyloid fibril protein in familial amyloidotic polyneuropathy, Portuguese type. Definition of molecular abnormality in transthyretin (prealbumin).

21 January 2018

1 reference

Alzheimer's disease: genotypes, phenotypes, and treatments

21 January 2018

1 reference

21 January 2018

1 reference

A role for destabilizing amino acid replacements in light-chain amyloidosis

21 January 2018

1 reference

Partially folded intermediates as critical precursors of light chain amyloid fibrils and amorphous aggregates.

21 January 2018

1 reference

Protein aggregation in Huntington's and Parkinson's disease: implications for therapy.

21 January 2018

1 reference

Protein aggregation and pathogenesis of Huntington's disease: mechanisms and correlations

21 January 2018

1 reference

Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathology

21 January 2018

1 reference

Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid

21 January 2018

1 reference

Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson's disease?

21 January 2018

1 reference

Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

21 January 2018

1 reference

Transmissible spongiform encephalopathies, amyloidoses and yeast prions: common threads?

21 January 2018

1 reference

Trans-suppression of misfolding in an amyloid disease.

21 January 2018

1 reference

Amyloid beta-protein and the genetics of Alzheimer's disease

21 January 2018

1 reference

Support for the multigenic hypothesis of amyloidosis: the binding stoichiometry of retinol-binding protein, vitamin A, and thyroid hormone influences transthyretin amyloidogenicity in vitro

21 January 2018

1 reference

APOE genotype predicts when--not whether--one is predisposed to develop Alzheimer disease.

21 January 2018

1 reference

APOE is a major susceptibility gene for Alzheimer's disease

21 January 2018

1 reference

Anion shielding of electrostatic repulsions in transthyretin modulates stability and amyloidosis: insight into the chaotrope unfolding dichotomy

21 January 2018

1 reference

Cryo-electron microscopy structure of an SH3 amyloid fibril and model of the molecular packing

21 January 2018

1 reference

Common core structure of amyloid fibrils by synchrotron X-ray diffraction.

21 January 2018

1 reference

Serum amyloid P component scintigraphy in familial amyloid polyneuropathy: regression of visceral amyloid following liver transplantation.

21 January 2018

1 reference

Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?

21 January 2018

1 reference

Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease.

21 January 2018

1 reference

Partial denaturation of transthyretin is sufficient for amyloid fibril formation in vitro

21 January 2018

1 reference

The acid-mediated denaturation pathway of transthyretin yields a conformational intermediate that can self-assemble into amyloid

21 January 2018

1 reference

Comparison of lethal and nonlethal transthyretin variants and their relationship to amyloid disease

21 January 2018

1 reference

An engineered transthyretin monomer that is nonamyloidogenic, unless it is partially denatured

21 January 2018

1 reference

Characterization of the transthyretin acid denaturation pathways by analytical ultracentrifugation: implications for wild-type, V30M, and L55P amyloid fibril formation

21 January 2018

1 reference

A glimpse of a possible amyloidogenic intermediate of transthyretin

21 January 2018

1 reference

Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis

21 January 2018

1 reference

Mutations and off-pathway aggregation of proteins

21 January 2018

1 reference

Protein misfolding, evolution and disease

21 January 2018

1 reference

Inhibiting transthyretin amyloid fibril formation via protein stabilization

21 January 2018

1 reference

Inhibiting transthyretin conformational changes that lead to amyloid fibril formation

21 January 2018

1 reference

Rational design of potent human transthyretin amyloid disease inhibitors

21 January 2018

1 reference

Synthesis and evaluation of inhibitors of transthyretin amyloid formation based on the non-steroidal anti-inflammatory drug, flufenamic acid

21 January 2018

1 reference

Designing conditions for in vitro formation of amyloid protofilaments and fibrils

21 January 2018

1 reference

Identification and characterization of key kinetic intermediates in amyloid beta-protein fibrillogenesis

21 January 2018

1 reference

Screening for pharmacologic inhibitors of amyloid fibril formation.

21 January 2018

1 reference

Intracellular accumulation of insoluble, newly synthesized abetan-42 in amyloid precursor protein-transfected cells that have been treated with Abeta1-42.

21 January 2018

1 reference

The V122I cardiomyopathy variant of transthyretin increases the velocity of rate-limiting tetramer dissociation, resulting in accelerated amyloidosis

21 January 2018

1 reference

Deuterium-proton exchange on the native wild-type transthyretin tetramer identifies the stable core of the individual subunits and indicates mobility at the subunit interface

21 January 2018

1 reference

Evaluating the binding selectivity of transthyretin amyloid fibril inhibitors in blood plasma

21 January 2018

1 reference

Synthesis, structure, and activity of diclofenac analogues as transthyretin amyloid fibril formation inhibitors

21 January 2018

1 reference

Disruption of protein-protein interactions: design of a synthetic receptor that blocks the binding of cytochrome c to cytochrome c peroxidase.

21 January 2018

1 reference

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

21 January 2018

1 reference

Abeta immunization: moving Abeta peptide from brain to blood

21 January 2018

1 reference

Characterization of the structure and function of W --> F WW domain variants: identification of a natively unfolded protein that folds upon ligand binding

21 January 2018

1 reference

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

1 reference

Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia

21 January 2018

1 reference

Mimicking dominant negative inhibition of prion replication through structure-based drug design

21 January 2018

1 reference

Arresting amyloidosis in vivo using small-molecule anionic sulphonates or sulphates: implications for Alzheimer's disease.

21 January 2018

1 reference

The heparin/heparan sulfate-binding site on apo-serum amyloid A. Implications for the therapeutic intervention of amyloidosis.

21 January 2018

1 reference

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease.

21 January 2018

1 reference

Antibodies inhibit prion propagation and clear cell cultures of prion infectivity

21 January 2018

1 reference

Synchrotron X-ray studies suggest that the core of the transthyretin amyloid fibril is a continuous β-sheet helix

21 January 2018

1 reference

Examination of the Structure of the Transthyretin Amyloid Fibril by Image Reconstruction from Electron Micrographs

21 January 2018

1 reference

The protofilament substructure of amyloid fibrils11Edited by F. E. Cohen

21 January 2018

1 reference

A chemical approach to elucidate tin mechanism of transthyretin and β-protein amyloid fibril formation

21 January 2018

1 reference

Formation and seeding of amyloid fibrils from wild-type hen lysozyme and a peptide fragment from the β-domain

21 January 2018

1 reference

21 January 2018

1 reference

31 March 2020

1 reference

The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation

31 March 2020

1 reference

Amyloid hypothesis of Alzheimer's rides high--for now

31 March 2020

1 reference

Synthesis and evaluation of anthranilic acid-based transthyretin amyloid fibril inhibitors

31 March 2020

1 reference

Discovering transthyretin amyloid fibril inhibitors by limited screening

31 March 2020

1 reference

Transthyretin quaternary and tertiary structural changes facilitate misassembly into amyloid.

31 March 2020

1 reference

Modulation of beta-amyloid production and fibrillization.

31 March 2020

1 reference

Self-assembly of beta-amyloid 42 is retarded by small molecular ligands at the stage of structural intermediates

31 March 2020

1 reference

Design and testing of inhibitors of fibril formation

31 March 2020

1 reference

Creation of "Amyloid" Fibrils from Bence Jones Proteins in vitro

31 March 2020

1 reference

Accelerated transport and maturation of lysosomal α–galactosidase A in Fabry lymphoblasts by an enzyme inhibitor

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRD769

1 reference

4 August 2017

1 reference

PubMed ID

12120278