(Q57903792)

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Regulating 56 kinase

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Regulating 56 kinase (English)

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Julian Downward

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Julian Downward

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September 1994

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371

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6496

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378-379

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The hunt for Ras targets

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Activation of p70/p85 S6 kinase by a pathway independent of p21ras

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PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

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p70s6k function is essential for G1 progression

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Nuclear localization of p85s6k: functional requirement for entry into S phase.

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Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

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Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase

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Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family

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Phosphorylation of the ribosomal protein S6 is elevated in cells transformed by a variety of tumor viruses

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ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

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Epidermal growth factor induces phosphorylation of extracellular signal-regulated kinase 2 via multiple pathways

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The assembly of signalling complexes by receptor tyrosine kinases

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A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase

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Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation

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Phosphatidylinositol-3-OH kinase as a direct target of Ras

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The activation of phosphatidylinositol 3-kinase by Ras

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Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor

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A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein beta gamma subunits

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A comparison of demethoxyviridin and wortmannin as inhibitors of phosphatidylinositol 3-kinase.

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Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

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A mammalian protein targeted by G1-arresting rapamycin-receptor complex

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RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

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Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting

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based on heuristic

inferred from DOI database lookup

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10.1038/371378A0

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