(Q57911995)

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Induction of a non-encephalitogenic type 2 T helper-cell autoimmune responsein multiple sclerosis after administration of an altered peptide ligand ina placebo-controlled, randomized phase II trial

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scholarly article

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Induction of a non-encephalitogenic type 2 T helper-cell autoimmune responsein multiple sclerosis after administration of an altered peptide ligand ina placebo-controlled, randomized phase II trial (English)

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multiple sclerosis

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phase II clinical trial

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1

object named as

Ludwig Kappos

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object named as

Giancarlo Comi

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42

object named as

Alan Evans

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Pierre Duquette

35

object named as

Pierre Duquette

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author name string

Hillel Panitch

3

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Joel Oger

4

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Jack Antel

5

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Paul Conlon

6

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Lawrence Steinman

7

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Giancarlo Comi

8

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Ludwig Kappos

9

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Joel Oger

10

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Hillel Panitch

11

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Alexander Rae-Grant

12

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John Castaldo

13

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Nancy Eckert

14

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Joseph B. Guarnaccia

15

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Pamela Mills

16

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Gary Johnson

17

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Peter A. Calabresi

18

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Carlo Pozzilli

19

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Stefano Bastianello

20

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Elisabetta Giugni

21

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Tatiana Witjas

22

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Patrick Cozzone

23

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Jean Pelletier

24

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Dieter Pöhlau

25

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Horst Przuntek

26

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Volker Hoffmann

27

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Christopher Bever

28

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Eleanor Katz

29

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Michel Clanet

30

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Isabelle Berry

31

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David Brassat

32

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Irene Brunet

33

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Gilles Edan

34

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Ernst-Wilhelm Radue

36

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Dagmar Schött

37

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Carmen Lienert

38

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Alice Taksaoui

39

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M. Rodegher

40

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M. Filippi

41

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Pierre Bourgouin

43

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Alex Zijdenbos

44

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Shawki Salem

45

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Nicholas Ling

46

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David Alleva

47

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Eric Johnson

48

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Amitabh Gaur

49

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Paul Crowe

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Xin-Jun Liu

51

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language of work or name

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publication date

October 2000

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Nature Medicine

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6

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10

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1176-1182

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https://scigraph.springernature.com/pub.10.1038/80525

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Immunological aspects of demyelinating diseases

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https://api.crossref.org/works/10.1038%2F80525

7 January 2021

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Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system

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https://api.crossref.org/works/10.1038%2F80525

7 January 2021

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Progress in determining the causes and treatment of multiple sclerosis

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https://api.crossref.org/works/10.1038%2F80525

7 January 2021

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A full genome search in multiple sclerosis

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https://api.crossref.org/works/10.1038%2F80525

7 January 2021

based on heuristic

inferred from DOI database lookup

A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22

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https://api.crossref.org/works/10.1038%2F80525

7 January 2021

based on heuristic

inferred from DOI database lookup

A complete genomic screen for multiple sclerosis underscores a role for the major histocompatability complex. The Multiple Sclerosis Genetics Group

1 reference

https://api.crossref.org/works/10.1038%2F80525

7 January 2021

based on heuristic

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Visualization of myelin basic protein (MBP) T cell epitopes in multiple sclerosis lesions using a monoclonal antibody specific for the human histocompatibility leukocyte antigen (HLA)-DR2-MBP 85-99 complex

1 reference

https://api.crossref.org/works/10.1038%2F80525

7 January 2021

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Selection for T-cell receptor V beta-D beta-J beta gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis

1 reference

https://api.crossref.org/works/10.1038%2F80525

7 January 2021

based on heuristic

inferred from DOI database lookup

T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis

1 reference

https://api.crossref.org/works/10.1038%2F80525

7 January 2021

based on heuristic

inferred from DOI database lookup

A myelin basic protein peptide is recognized by cytotoxic T cells in the context of four HLA-DR types associated with multiple sclerosis

1 reference

https://api.crossref.org/works/10.1038%2F80525

7 January 2021

based on heuristic

inferred from DOI database lookup

Major T-cell responses in multiple sclerosis.

1 reference

https://api.crossref.org/works/10.1038%2F80525

7 January 2021

based on heuristic

inferred from DOI database lookup

Reversal of experimental autoimmune encephalomyelitis by a soluble peptide variant of a myelin basic protein epitope: T cell receptor antagonism and reduction of interferon gamma and tumor necrosis factor alpha production

1 reference

https://api.crossref.org/works/10.1038%2F80525

7 January 2021

based on heuristic

inferred from DOI database lookup

Amelioration of relapsing experimental autoimmune encephalomyelitis with altered myelin basic protein peptides involves different cellular mechanisms

1 reference

https://api.crossref.org/works/10.1038%2F80525

7 January 2021

based on heuristic

inferred from DOI database lookup

Analysis of an IFN- gamma gene (IFNG) Polymorphism in Multiple Sclerosis in Europe: Effect of Population Structure on Association with Disease

1 reference

https://api.crossref.org/works/10.1038%2F80525

7 January 2021

based on heuristic

inferred from DOI database lookup

Immunologic therapy of multiple sclerosis

1 reference

https://api.crossref.org/works/10.1038%2F80525

7 January 2021

based on heuristic

inferred from DOI database lookup

Escape from "horror autotoxicus": pathogenesis and treatment of autoimmune disease

1 reference

https://api.crossref.org/works/10.1038%2F80525

7 January 2021

based on heuristic

inferred from DOI database lookup

Viral damage and the breakdown of self-tolerance

1 reference

https://api.crossref.org/works/10.1038%2F80525

7 January 2021

based on heuristic

inferred from DOI database lookup

Treatment of multiple sclerosis with gamma interferon: exacerbations associated with activation of the immune system

1 reference

https://api.crossref.org/works/10.1038%2F80525

7 January 2021

based on heuristic

inferred from DOI database lookup

Cytokine profile of myelin basic protein-reactive T cells in multiple sclerosis and healthy individuals.

1 reference

https://api.crossref.org/works/10.1038%2F80525

7 January 2021

based on heuristic

inferred from DOI database lookup

Augmented expression of tumour necrosis factor-alpha and lymphotoxin in mononuclear cells in multiple sclerosis and optic neuritis.

1 reference

https://api.crossref.org/works/10.1038%2F80525

7 January 2021

based on heuristic

inferred from DOI database lookup

Tumor necrosis factor identified in multiple sclerosis brain

1 reference

https://api.crossref.org/works/10.1038%2F80525

7 January 2021

based on heuristic

inferred from DOI database lookup

The adhesion molecule and cytokine profile of multiple sclerosis lesions

1 reference

https://api.crossref.org/works/10.1038%2F80525

7 January 2021

based on heuristic

inferred from DOI database lookup

Multiple sclerosis: involvement of interferons in lesion pathogenesis

1 reference

https://api.crossref.org/works/10.1038%2F80525

7 January 2021

based on heuristic

inferred from DOI database lookup

Distinct patterns of multiple sclerosis pathology indicates heterogeneity on pathogenesis

1 reference

https://api.crossref.org/works/10.1038%2F80525

7 January 2021

based on heuristic

inferred from DOI database lookup

Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein

1 reference

https://api.crossref.org/works/10.1038%2F80525

7 January 2021

based on heuristic

inferred from DOI database lookup

Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand

1 reference

https://api.crossref.org/works/10.1038%2F80525

7 January 2021

based on heuristic

inferred from DOI database lookup

Binding of myelin basic protein peptides to human histocompatibility leukocyte antigen class II molecules and their recognition by T cells from multiple sclerosis patients

1 reference

https://api.crossref.org/works/10.1038%2F80525

7 January 2021

based on heuristic

inferred from DOI database lookup

Copolymer 1 acts against the immunodominant epitope 82-100 of myelin basic protein by T cell receptor antagonism in addition to major histocompatibility complex blocking

1 reference

https://api.crossref.org/works/10.1038%2F80525

7 January 2021

based on heuristic

inferred from DOI database lookup

Glatiramer acetate (Copaxone) induces degenerate, Th2-polarized immune responses in patients with multiple sclerosis

1 reference

https://api.crossref.org/works/10.1038%2F80525

7 January 2021

based on heuristic

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Treatment of multiple sclerosis with T-cell receptor peptides: results of a double-blind pilot trial

1 reference

https://api.crossref.org/works/10.1038%2F80525

7 January 2021

based on heuristic

inferred from DOI database lookup

Preferential T-cell receptor beta-chain variable gene use in myelin basic protein-reactive T-cell clones from patients with multiple sclerosis

1 reference

https://api.crossref.org/works/10.1038%2F80525

7 January 2021

based on heuristic

inferred from DOI database lookup

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