(Q58003103)

English

Sex and CYP3A5 genotype influence total CYP3A activity: high CYP3A activity and a unique distribution of CYP3A5 variant alleles in Ethiopians

article by E Gebeyehu et al published 16 March 2010 in The Pharmacogenomics Journal

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scholarly article

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Sex and CYP3A5 genotype influence total CYP3A activity: high CYP3A activity and a unique distribution of CYP3A5 variant alleles in Ethiopians (English)

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object named as

U Diczfalusy

5

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Ephrem Engidawork

object named as

E Engidawork

2

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object named as

E Aklillu

6

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author name string

E Gebeyehu

1

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A Bijnsdorp

3

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A Aminy

4

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publication date

16 March 2010

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The Pharmacogenomics Journal

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11

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2

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130-137

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https://scigraph.springernature.com/pub.10.1038/tpj.2010.16

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Developmental expression of the major human hepatic CYP3A enzymes

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Molecular mechanisms of polymorphic CYP3A7 expression in adult human liver and intestine

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Genetic contribution to variable human CYP3A-mediated metabolism

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Significance of the minor cytochrome P450 3A isoforms.

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4Beta-hydroxycholesterol is a new endogenous CYP3A marker: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians

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The influence of age and sex on the clearance of cytochrome P450 3A substrates

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How important are gender differences in pharmacokinetics?

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Sex is a major determinant of CYP3A4 expression in human liver

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Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

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CYP3A5 genotype has significant effect on quinine 3-hydroxylation in Tanzanians, who have lower total CYP3A activity than a Swedish population

1 reference

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Increased levels of aflatoxin-albumin adducts are associated with CYP3A5 polymorphisms in The Gambia, West Africa

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Novel variants of major drug-metabolising enzyme genes in diverse African populations and their predicted functional effects

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Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: evidence for involvement of cytochrome p450 3A4.

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S-mephenytoin hydroxylation phenotype and CYP2C19 genotype among Ethiopians

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Different genetic components in the Ethiopian population, identified by mtDNA and Y-chromosome polymorphisms

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Ethiopia: between Sub-Saharan Africa and Western Eurasia

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Genetic evidence for complexity in ethnic differentiation and history in East Africa

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Ethiopian mitochondrial DNA heritage: tracking gene flow across and around the gate of tears

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Allele-specific expression and gene methylation in the control of CYP1A2 mRNA level in human livers

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Effects of the CYP3A5 genotype on omeprazole sulfoxidation in CYP2C19 PMs.

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Cytochrome P450 induction by rifampicin in healthy subjects: determination using the Karolinska cocktail and the endogenous CYP3A4 marker 4beta-hydroxycholesterol

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Time course of the increase in 4beta-hydroxycholesterol concentration during carbamazepine treatment of paediatric patients with epilepsy

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4beta-hydroxycholesterol as an endogenous marker for CYP3A4/5 activity. Stability and half-life of elimination after induction with rifampicin

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Metabolism of 4 beta -hydroxycholesterol in humans.

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CYP3A induction and inhibition by different antiretroviral regimens reflected by changes in plasma 4beta-hydroxycholesterol levels

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Plasma 4beta-hydroxycholesterol: an endogenous CYP3A metric?

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No role for the CYP3A5*3 polymorphism in intestinal and hepatic metabolism of midazolam

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Comparative pharmacokinetics of midazolam and loprazolam in healthy subjects after oral administration.

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Failure of erythromycin breath test to correlate with midazolam clearance as a probe of cytochrome P4503A.

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Effect of CYP3A5 genotype on renal allograft recipients treated with tacrolimus.

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10.1038/TPJ.2010.16

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