(Q58116467)

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Pharmacological inhibition or small interfering RNA targeting acid ceramidase sensitizes hepatoma cells to chemotherapy and reduces tumor growth in vivo

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27 December 2019

Pharmacological inhibition or small interfering RNA targeting acid ceramidase sensitizes hepatoma cells to chemotherapy and reduces tumor growth in vivo (English)

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27 December 2019

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hepatocellular carcinoma

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based on heuristic

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1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16862171%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

José C Fernández-Checa

6

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27 December 2019

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París R

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27 December 2019

Villanueva A

3

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27 December 2019

Llacuna L

4

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27 December 2019

García-Ruiz C

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27 December 2019

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24 July 2006

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27 December 2019

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27 December 2019

26

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27 December 2019

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27 December 2019

905-916

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27 December 2019

https://scigraph.springernature.com/pub.10.1038/sj.onc.1209834

0 references

(1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol as an inhibitor of ceramidase

1 reference

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7 January 2021

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Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular viral oncology of hepatocellular carcinoma

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209834

7 January 2021

based on heuristic

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The role of ceramide in receptor- and stress-induced apoptosis studied in acidic ceramidase-deficient Farber disease cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209834

7 January 2021

based on heuristic

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Ganglioside GD3 enhances apoptosis by suppressing the nuclear factor-kappa B-dependent survival pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209834

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential regulation of sphingomyelinase and ceramidase activities by growth factors and cytokines. Implications for cellular proliferation and differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209834

7 January 2021

based on heuristic

inferred from DOI database lookup

Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209834

7 January 2021

based on heuristic

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Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209834

7 January 2021

based on heuristic

inferred from DOI database lookup

N,N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209834

7 January 2021

based on heuristic

inferred from DOI database lookup

Interleukin-1beta induces chronic activation and de novo synthesis of neutral ceramidase in renal mesangial cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209834

7 January 2021

based on heuristic

inferred from DOI database lookup

Defective TNF-alpha-mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209834

7 January 2021

based on heuristic

inferred from DOI database lookup

Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen Species

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209834

7 January 2021

based on heuristic

inferred from DOI database lookup

Trafficking of ganglioside GD3 to mitochondria by tumor necrosis factor-alpha

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209834

7 January 2021

based on heuristic

inferred from DOI database lookup

Direct interaction of GD3 ganglioside with mitochondria generates reactive oxygen species followed by mitochondrial permeability transition, cytochrome c release, and caspase activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209834

7 January 2021

based on heuristic

inferred from DOI database lookup

Ceramide Induces CytochromecRelease from Isolated Mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209834

7 January 2021

based on heuristic

inferred from DOI database lookup

A role for caspase-8 and c-FLIPL in proliferation and cell-cycle progression of primary hepatocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209834

7 January 2021

based on heuristic

inferred from DOI database lookup

Involvement of tyrosine kinase p56/Lck in apoptosis induction by anticancer drugs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209834

7 January 2021

based on heuristic

inferred from DOI database lookup

p53-Independent ceramide formation in human glioma cells during gamma-radiation-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209834

7 January 2021

based on heuristic

inferred from DOI database lookup

Daunorubicin-induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209834

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential gene alteration among hepatoma cell lines demonstrated by cDNA microarray-based comparative genomic hybridization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209834

7 January 2021

based on heuristic

inferred from DOI database lookup

Mitochondrial permeability transition: a common pathway to necrosis and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209834

7 January 2021

based on heuristic

inferred from DOI database lookup

The therapeutic potential of modulating the ceramide/sphingomyelin pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209834

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of ceramide production and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209834

7 January 2021

based on heuristic

inferred from DOI database lookup

The human acid ceramidase gene (ASAH): structure, chromosomal location, mutation analysis, and expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209834

7 January 2021

based on heuristic

inferred from DOI database lookup

Ceramide glycosylation potentiates cellular multidrug resistance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209834

7 January 2021

based on heuristic

inferred from DOI database lookup

Mitochondrial lipid alterations during Fas- and radiation-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209834

7 January 2021

based on heuristic

inferred from DOI database lookup

Cooperative prosurvival activity by ERK and Akt in human alveolar macrophages is dependent on high levels of acid ceramidase activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209834

7 January 2021

based on heuristic

inferred from DOI database lookup

Bimodal regulation of ceramidase by interleukin-1beta. Implications for the regulation of cytochrome p450 2C11.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209834

7 January 2021

based on heuristic

inferred from DOI database lookup

Biologically active sphingolipids in cancer pathogenesis and treatment

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209834

7 January 2021

based on heuristic

inferred from DOI database lookup

Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209834

7 January 2021

based on heuristic

inferred from DOI database lookup

Sphingosine 1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspring

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209834

7 January 2021

based on heuristic

inferred from DOI database lookup

Ganglioside GD3 sensitizes human hepatoma cells to cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209834

7 January 2021

based on heuristic

inferred from DOI database lookup

Analysis of the sequence of amino acids surrounding sites of tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209834

7 January 2021

based on heuristic

inferred from DOI database lookup

Sphingosine-1-phosphate: dual messenger functions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209834

7 January 2021

based on heuristic

inferred from DOI database lookup

Lack of ceramide generation and altered sphingolipid composition are associated with drug resistance in human ovarian carcinoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209834

7 January 2021

based on heuristic

inferred from DOI database lookup

Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209834

7 January 2021

based on heuristic

inferred from DOI database lookup

GD3 ganglioside directly targets mitochondria in a bcl-2-controlled fashion

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209834

7 January 2021

based on heuristic

inferred from DOI database lookup

Commitment to apoptosis by GD3 ganglioside depends on opening of the mitochondrial permeability transition pore.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209834

7 January 2021

based on heuristic

inferred from DOI database lookup

Sphingosine-1-phosphate: an enigmatic signalling lipid

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209834

7 January 2021

based on heuristic

inferred from DOI database lookup

Overexpression of acid ceramidase protects from tumor necrosis factor-induced cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209834

7 January 2021

based on heuristic

inferred from DOI database lookup

Ceramidase and ceramide synthesis in human kidney and cerebellum. Description of a new alkaline ceramidase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209834

7 January 2021

based on heuristic

inferred from DOI database lookup

Sphingosine-dependent apoptosis: a unified concept based on multiple mechanisms operating in concert

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209834

7 January 2021

based on heuristic

inferred from DOI database lookup

N,N-dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209834

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SJ.ONC.1209834

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16862171%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16862171%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

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