(Q58616150)

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Bioflavonoids promote stable translocations between MLL-AF9 breakpoint cluster regions independent of normal chromosomal context: Model system to screen environmental risks

scientific article published on 02 November 2018

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1 May 2020

Bioflavonoids promote stable translocations between MLL-AF9 breakpoint cluster regions independent of normal chromosomal context: Model system to screen environmental risks (English)

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1 May 2020

Christine Richardson

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Christine Richardson

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1 May 2020

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Bhawana Bariar

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1 May 2020

C Greer Vestal

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1 May 2020

Bradley Deem

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1 May 2020

Donna Goodenow

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1 May 2020

Mimi Ughetta

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1 May 2020

R Warren Engledove

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1 May 2020

Mark Sahyouni

7

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1 May 2020

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2 November 2018

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1 May 2020

Environmental and Molecular Mutagenesis

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1 May 2020

60

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1 May 2020

2

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1 May 2020

154-167

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1 May 2020

Genistein induces topoisomerase IIbeta- and proteasome-mediated DNA sequence rearrangements: Implications in infant leukemia

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

Bioflavonoids as poisons of human topoisomerase II alpha and II beta

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

Long-term effects of chromatin remodeling and DNA damage in stem cells induced by environmental and dietary agents

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

Dietary flavonoids induce MLL translocations in primary human CD34+ cells

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

Polychlorinated biphenyl quinone metabolites poison human topoisomerase IIalpha: altering enzyme function by blocking the N-terminal protein gate.

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

Etoposide induces chimeric Mll gene fusions

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of chemopreventive natural products on non-homologous end-joining DNA double-strand break repair

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

Profiling dose-dependent activation of p53-mediated signaling pathways by chemicals with distinct mechanisms of DNA damage

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

Placental transfer of the soy isoflavone genistein following dietary and gavage administration to Sprague Dawley rats

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

Chromosomal translocation mechanisms at intronic alu elements in mammalian cells

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

Topoisomerase II and the etiology of chromosomal translocations

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

Multipotent hematopoietic cells susceptible to alternative double-strand break repair pathways that promote genome rearrangements

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

Backtracking leukemia to birth: identification of clonotypic gene fusion sequences in neonatal blood spots

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

A role for epigenetics in the formation of chromosome translocations in acute leukemia

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

The bone marrow niche, stem cells, and leukemia: impact of drugs, chemicals, and the environment

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

Distinct requirements for the Rad32(Mre11) nuclease and Ctp1(CtIP) in the removal of covalently bound topoisomerase I and II from DNA.

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

Phytoestrogen consumption and breast cancer risk in a multiethnic population: the Bay Area Breast Cancer Study.

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

Rearrangements of the MLL gene are influenced by DNA secondary structure, potentially mediated by topoisomerase II binding.

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA.

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

Therapy-related acute myeloid leukemia-like MLL rearrangements are induced by etoposide in primary human CD34+ cells and remain stable after clonal expansion

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

1,4-Benzoquinone is a topoisomerase II poison

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

Near-precise interchromosomal recombination and functional DNA topoisomerase II cleavage sites at MLL and AF-4 genomic breakpoints in treatment-related acute lymphoblastic leukemia with t(4;11) translocation

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

Intakes and sources of soya foods and isoflavones in a UK population cohort study (EPIC-Norfolk).

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

Efficient selection for high-expression transfectants with a novel eukaryotic vector

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of dietary flavonoids on major signal transduction pathways in human epithelial cells

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanism of action of topoisomerase II-targeted antineoplastic drugs

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of DNA fragmentation events caused by genotoxic and non-genotoxic agents

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

Infant Acute Leukemia and Maternal Exposures during Pregnancy

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

Frequent chromosomal translocations induced by DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

Dietary flavonoids and the MLL gene: A pathway to infant leukemia?

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

Dietary flavonoids: bioavailability, metabolic effects, and safety

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

Genistein, isoflavonoids in soybeans, prevents the formation of excess radiation-induced centrosomes via p21 up-regulation

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

Leukemia and benzene

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

DNA structural properties of AF9 are similar to MLL and could act as recombination hot spots resulting in MLL/AF9 translocations and leukemogenesis

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

Fetal exposure to phytoestrogens--the difference in phytoestrogen status between mother and fetus

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

Prenatal exposure to flavonoids: implication for cancer risk

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

Stem cell and benzene-induced malignancy and hematotoxicity

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

Residential levels of polybrominated diphenyl ethers and risk of childhood acute lymphoblastic leukemia in California

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

Prenatal origin of acute lymphoblastic leukaemia in children

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

Homologous recombination initiated by benzene metabolites: a potential role of oxidative stress

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

Analysis of foetal expression sites of human type II DNA topoisomerase alpha and beta mRNAs by in situ hybridisation.

1 reference

https://api.crossref.org/works/10.1002%2FEM.22245

7 January 2021

based on heuristic

inferred from DOI database lookup

Sequence analysis of the breakpoint cluster region in the ALL-1 gene involved in acute leukemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30387535

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rearrangements of the MLL gene in therapy-related acute myeloid leukemia in patients previously treated with agents targeting DNA-topoisomerase II

1 reference

https://pubmed.ncbi.nlm.nih.gov/30387535

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potential topoisomerase II DNA-binding sites at the breakpoints of a t(9;11) chromosome translocation in acute myeloid leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/30387535

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution of 11q23 breakpoints within the MLL breakpoint cluster region in de novo acute leukemia and in treatment-related acute myeloid leukemia: correlation with scaffold attachment regions and topoisomerase II consensus binding sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/30387535

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative DNA damage and apoptosis induced by benzene metabolites.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30387535

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthetic flavonoids cross the placenta in the rat and are found in fetal brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30387535

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transplacental chemical exposure and risk of infant leukemia with MLL gene fusion.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30387535

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptotic triggers initiate translocations within the MLL gene involving the nonhomologous end joining repair system

1 reference

https://pubmed.ncbi.nlm.nih.gov/30387535

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

G2 arrest in response to topoisomerase II inhibitors: the role of p53.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30387535

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/EM.22245

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30387535%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30387535%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30387535%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

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