(Q44650227)

5 December 2017

Effects of dietary flavonoids on major signal transduction pathways in human epithelial cells (English)

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5 December 2017

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

31 March 2024

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https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

31 March 2024

author name string

Jim O'Prey

1

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5 December 2017

Judith Brown

2

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5 December 2017

Janis Fleming

3

1 reference

5 December 2017

Paul R. Harrison

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14609732

31 March 2024

language of work or name

English

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publication date

1 December 2003

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full work available at URL

5 December 2017

https://api.elsevier.com/content/article/PII:S0006295203005938?httpAccept=text/xml

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

https://api.elsevier.com/content/article/PII:S0006295203005938?httpAccept=text/plain

31 March 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

31 March 2024

published in

Biochemical Pharmacology

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5 December 2017

66

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5 December 2017

11

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5 December 2017

2075-2088

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Dietary flavonoids and cancer risk in the Zutphen elderly study

5 December 2017

1

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Flavonoid Intake and Long-term Risk of Coronary Heart Disease and Cancer in the Seven Countries Study

31 March 2024

2

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Intake of potentially anticarcinogenic flavonoids and their determinants in adults in The Netherlands

31 March 2024

3

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands

31 March 2024

4

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Dietary flavonoids and the risk of lung cancer and other malignant neoplasms.

31 March 2024

5

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Intake of flavonoids and lung cancer

31 March 2024

6

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Potential health effects of the dietary flavonol quercetin

31 March 2024

7

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Absorption, metabolism and health effects of dietary flavonoids in man

31 March 2024

8

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Plant-derived phenolic antioxidants

31 March 2024

10

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Dietary flavonoids: intake, health effects and bioavailability

31 March 2024

11

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Quercetin and rutin as inhibitors of azoxymethanol-induced colonic neoplasia.

31 March 2024

12

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Effects of the phytochemicals, curcumin and quercetin, upon azoxymethane-induced colon cancer and 7,12-dimethylbenz[a]anthracene-induced mammary cancer in rats.

31 March 2024

13

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Inhibition of 7,12-dimethylbenz(a)anthracene- and N-nitrosomethylurea-induced rat mammary cancer by dietary flavonol quercetin

31 March 2024

14

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Inhibitory effect of dietary flavonol quercetin on 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis

31 March 2024

15

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Possible involvement of arachidonic acid metabolism in phenobarbital promotion of hepatocarcinogenesis

31 March 2024

16

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and ornithine decarboxylase activity by quercetin: possible involvement of lipoxygenase inhibition.

31 March 2024

18

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Inhibition of ultraviolet light induced skin carcinogenesis in SKH-1 mice by apigenin, a plant flavonoid

31 March 2024

21

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Dietary agents in cancer prevention: flavonoids and isoflavonoids.

31 March 2024

23

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

The therapeutic potential of flavonoids

31 March 2024

24

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms.

31 March 2024

25

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Phase II study of the cyclin-dependent kinase inhibitor flavopiridol administered to patients with advanced gastric carcinoma.

31 March 2024

26

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Flavopiridol, the first cyclin-dependent kinase inhibitor to enter the clinic: current status

31 March 2024

27

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Structure-antioxidant activity relationships of flavonoids and phenolic acids

31 March 2024

28

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Differential effects of flavonoids as inhibitors of tyrosine protein kinases and serine/threonine protein kinases.

31 March 2024

29

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Protein kinase C inhibition by plant flavonoids. Kinetic mechanisms and structure-activity relationships

31 March 2024

30

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Relationship between flavonoid structure and inhibition of phosphatidylinositol 3-kinase: a comparison with tyrosine kinase and protein kinase C inhibition.

31 March 2024

31

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Inhibitions of protein kinase C and proto-oncogene expressions in NIH 3T3 cells by apigenin

31 March 2024

32

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Quercetin down-regulates signal transduction in human breast carcinoma cells

31 March 2024

33

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.

31 March 2024

34

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Potent inhibition of CDC2 kinase activity by the flavonoid L86-8275.

31 March 2024

35

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Inhibition of mammalian 5-lipoxygenase and cyclo-oxygenase by flavonoids and phenolic dietary additives. Relationship to antioxidant activity and to iron ion-reducing ability

31 March 2024

36

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

In vitro inhibition of mouse epidermal cell lipoxygenase by flavonoids: structure-activity relationships.

31 March 2024

37

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Effects of naturally-occurring flavonoids and biflavonoids on epidermal cyclooxygenase and lipoxygenase from guinea-pigs

31 March 2024

38

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Flavonoids and related compounds as inhibition of arachidonic acid peroxidation

31 March 2024

39

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Skin cancer chemopreventive effects of a flavonoid antioxidant silymarin are mediated via impairment of receptor tyrosine kinase signaling and perturbation in cell cycle progression.

31 March 2024

40

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Flavonoids with epidermal growth factor-receptor tyrosine kinase inhibitory activity stimulate PEPT1-mediated cefixime uptake into human intestinal epithelial cells

31 March 2024

41

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Reversion of v-H-ras-transformed NIH 3T3 cells by apigenin through inhibiting mitogen activated protein kinase and its downstream oncogenes.

31 March 2024

42

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Induction of p21/WAF1 and G1 cell-cycle arrest by the chemopreventive agent apigenin

31 March 2024

43

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

The chemopreventive flavonoid apigenin induces G2/M arrest in keratinocytes

31 March 2024

44

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: regulation of cyclin-dependent kinases CDK2 and CDK1.

31 March 2024

47

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

A p21(waf1)-independent pathway for inhibitory phosphorylation of cyclin-dependent kinase p34(cdc2) and concomitant G(2)/M arrest by the chemopreventive flavonoid apigenin

31 March 2024

48

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Cell signaling and regulators of cell cycle as molecular targets for prostate cancer prevention by dietary agents

31 March 2024

50

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Lignans and flavonoids inhibit aromatase enzyme in human preadipocytes

31 March 2024

51

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Inhibition of 17 -Hydroxysteroid Oxidoreductase by Flavonoids in Breast and Prostate Cancer Cells

31 March 2024

52

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Cellular immortality: a late event in the progression of human squamous cell carcinoma of the head and neck associated with p53 alteration and a high frequency of allele loss.

31 March 2024

57

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Molecular cloning and primary structure of human 15-lipoxygenase

31 March 2024

58

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Molecular cloning and amino acid sequence of human 5-lipoxygenase

31 March 2024

59

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Cloning of the cDNA for human 12-lipoxygenase

31 March 2024

60

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Discovery of a second 15S-lipoxygenase in humans

31 March 2024

61

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Big mitogen-activated protein kinase 1 (BMK1) is a redox-sensitive kinase

31 March 2024

62

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

31 March 2024

63

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

The search for physiological substrates of MAP and SAP kinases in mammalian cells

31 March 2024

64

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor

31 March 2024

65

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Activation of mitogen-activated protein kinase by H2O2. Role in cell survival following oxidant injury

31 March 2024

67

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

PI3K: downstream AKTion blocks apoptosis

31 March 2024

68

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Integrating stress-response and cell-cycle checkpoint pathways

31 March 2024

69

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Regulation of the G2/M transition by p53.

31 March 2024

70

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

ATM: a mediator of multiple responses to genotoxic stress

31 March 2024

73

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Cell-cycle checkpoint kinases: checking in on the cell cycle

31 March 2024

74

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Caffeine inhibits the checkpoint kinase ATM

31 March 2024

75

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity

31 March 2024

77

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Increased AKT activity contributes to prostate cancer progression by dramatically accelerating prostate tumor growth and diminishing p27Kip1 expression

31 March 2024

79

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Flavonoids and the inhibition of PKC and PI 3-kinase

31 March 2024

80

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

The p53 status of cultured human premalignant oral keratinocytes

31 March 2024

81

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Ionizing radiation activates the ATM kinase throughout the cell cycle

31 March 2024

82

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53.

31 March 2024

83

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Replication checkpoint: preventing mitotic catastrophe

31 March 2024

84

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

31 March 2024

86

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

31 March 2024

87

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

31 March 2024

88

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest

31 March 2024

90

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase

31 March 2024

91

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent manner

31 March 2024

92

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Distinct Chk2 activation pathways are triggered by genistein and DNA-damaging agents in human melanoma cells

31 March 2024

93

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Plasma concentrations and urinary excretion of the antioxidant flavonols quercetin and kaempferol as biomarkers for dietary intake

31 March 2024

95

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Red wine is a poor source of bioavailable flavonols in men

31 March 2024

97

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Relative bioavailability of the antioxidant flavonoid quercetin from various foods in man

31 March 2024

99

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Prediction of dietary flavonol consumption from fasting plasma concentration or urinary excretion

31 March 2024

100

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Bioavailabilities of quercetin-3-glucoside and quercetin-4'-glucoside do not differ in humans

31 March 2024

101

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats

31 March 2024

102

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

Enhanced sensitivity of human oral tumours to the flavonol, morin, during cancer progression: involvement of the Akt and stress kinase pathways.

31 March 2024

103

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2003.07.007

31 March 2024

Identifiers

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5 December 2017

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