(Q58867784)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18620524%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

review article

1 reference

title

DNA methylation: a promising target for the twenty-first century (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18620524%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

1

1 reference

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10 January 2020

Helena C Castro

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18620524%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

author name string

Gisela Dellamora-Ortiz

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18620524%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Luiz R Leão-Ferreira

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18620524%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Maria Gouveia

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18620524%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Esteban Braggio

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18620524%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Ilana Zalcberg

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18620524%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Dilvani O Santos

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18620524%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Saulo Bourguinhon

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18620524%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Lucio M Cabral

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18620524%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Carlos R Rodrigues

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18620524%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

language of work or name

English

0 references

publication date

1 August 2008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18620524%20AND%20SRC:MED&resulttype=core&format=json

Expert Opinion on Therapeutic Targets

10 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18620524%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

volume

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18620524%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18620524%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

page(s)

1035-1047

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18620524%20AND%20SRC:MED&resulttype=core&format=json

Targeting DNA methylation in cancer

10 January 2020

cites work

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DNA Methylation and Gene Function

21 January 2018

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AdoMet-dependent methylation, DNA methyltransferases and base flipping

21 January 2018

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Biochemistry and biology of mammalian DNA methyltransferases

21 January 2018

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Integration of foreign DNA and its consequences in mammalian systems

21 January 2018

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Chromatin-based silencing mechanisms

21 January 2018

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Therapeutic implications of DNA methylation

21 January 2018

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DNA methylation supports intrinsic epigenetic memory in mammalian cells

21 January 2018

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Formation of methylation patterns in the mammalian genome

21 January 2018

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DNA methylation and silencing of gene expression

21 January 2018

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Establishment and functional validation of a structural homology model for human DNA methyltransferase 1.

21 January 2018

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Suppression of intestinal neoplasia by deletion of Dnmt3b

21 January 2018

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The human Dnmt2 has residual DNA-(cytosine-C5) methyltransferase activity.

21 January 2018

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Two substrates are better than one: dual specificities for Dnmt2 methyltransferases

21 January 2018

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The use of prokaryotic DNA methyltransferases as experimental and analytical tools in modern biology

21 January 2018

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The DNA methyltransferases of mammals

21 January 2018

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Structure and function of DNA methyltransferases.

21 January 2018

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Enzymatic C5-cytosine methylation of DNA: mechanistic implications of new crystal structures for HhaL methyltransferase-DNA-AdoHcy complexes

21 January 2018

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Catalytic mechanism of DNA-(cytosine-C5)-methyltransferases revisited: covalent intermediate formation is not essential for methyl group transfer by the murine Dnmt3a enzyme

21 January 2018

1 reference

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Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements

21 January 2018

1 reference

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In vivo stabilization of the Dnmt1 (cytosine-5)- methyltransferase protein

21 January 2018

1 reference

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The activity of the murine DNA methyltransferase Dnmt1 is controlled by interaction of the catalytic domain with the N-terminal part of the enzyme leading to an allosteric activation of the enzyme after binding to methylated DNA

21 January 2018

1 reference

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Properties and localization of DNA methyltransferase in preimplantation mouse embryos: implications for genomic imprinting

21 January 2018

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A candidate mammalian DNA methyltransferase related to pmt1p of fission yeast

21 January 2018

1 reference

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Mammalian DNA (cytosine-5) methyltransferases and their expression

21 January 2018

1 reference

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Structure of human DNMT2, an enigmatic DNA methyltransferase homolog that displays denaturant-resistant binding to DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.8.1035

Cloning and analysis of a novel human putative DNA methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.8.1035

Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.8.1035

Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.8.1035

A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.8.1035

Cloning, expression and chromosome locations of the human DNMT3 gene family

21 January 2018

1 reference

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Isolation and initial characterization of a novel zinc finger gene, DNMT3L, on 21q22.3, related to the cytosine-5-methyltransferase 3 gene family

21 January 2018

1 reference

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DNMT3L stimulates the DNA methylation activity of Dnmt3a and Dnmt3b through a direct interaction

21 January 2018

1 reference

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The epigenetic progenitor origin of human cancer

21 January 2018

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New markers for cancer detection

21 January 2018

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Aberrant promoter CpG methylation as a molecular marker for disease monitoring in natural killer cell lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.8.1035

Inhibitors of DNA methylation: beyond myelodysplastic syndromes

21 January 2018

1 reference

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Methylation inhibitor therapy in the treatment of myelodysplastic syndrome

21 January 2018

1 reference

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5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy

21 January 2018

1 reference

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Combination therapy with DNA methyltransferase inhibitors in hematologic malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.8.1035

De novo DNA methyltransferases Dnmt3a and Dnmt3b primarily mediate the cytotoxic effect of 5-aza-2'-deoxycytidine.

21 January 2018

1 reference

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Suppression of intestinal neoplasia by DNA hypomethylation.

21 January 2018

1 reference

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Toxicity of 5-aza-2'-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation

21 January 2018

1 reference

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Induction of Tumors in Mice by Genomic Hypomethylation

21 January 2018

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Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases

21 January 2018

1 reference

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An essential role for DNA methyltransferase DNMT3B in cancer cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.8.1035

The novel DNA methylation inhibitor zebularine is effective against the development of murine T-cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.8.1035

Zebularine inhibits human acute myeloid leukemia cell growth in vitro in association with p15INK4B demethylation and reexpression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.8.1035

Psammaplins from the Sponge Pseudoceratina purpurea: Inhibition of Both Histone Deacetylase and DNA Methyltransferase

21 January 2018

1 reference

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Constrained analogues of procaine as novel small molecule inhibitors of DNA methyltransferase-1.

21 January 2018

1 reference

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Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.8.1035

Synthesis and in vitro evaluation of biotinylated RG108: a high affinity compound for studying binding interactions with human DNA methyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.8.1035

Review: recent clinical trials in epigenetic therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.8.1035

Efficacy of decitabine in the treatment of patients with chronic myelomonocytic leukemia (CMML).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.8.1035

Inhibition of DNA methylation by antisense oligonucleotide MG98 as cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.8.1035

A phase I biological study of MG98, an oligodeoxynucleotide antisense to DNA methyltransferase 1, in patients with high-risk myelodysplasia and acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.8.1035

Phase II trial of DNA methyltransferase 1 inhibition with the antisense oligonucleotide MG98 in patients with metastatic renal carcinoma: a National Cancer Institute of Canada Clinical Trials Group investigational new drug study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.8.1035

Acetylation and deacetylation of non-histone proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.8.1035

High-throughput screening for identification of small molecule inhibitors of histone acetyltransferases using scintillating microplates (FlashPlate).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.8.1035

Mutations truncating the EP300 acetylase in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.8.1035

Enzyme inhibitors from marine invertebrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.8.1035

Can the state of cancer chemotherapy resistance be reverted by epigenetic therapy?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.8.1035

A phase II study of epigenetic therapy with hydralazine and magnesium valproate to overcome chemotherapy resistance in refractory solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.8.1035

Reprogramming epigenetic silencing: artificial transcription factors synergize with chromatin remodeling drugs to reactivate the tumor suppressor mammary serine protease inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.8.1035

Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in hematopoietic malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.8.1035

The nonsteroidal anti-inflammatory drug NS398 reactivates SPARC expression via promoter demethylation to attenuate invasiveness of lung cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.8.1035

Combining epigenetic and cytotoxic therapy in the treatment of solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.8.1035

Phase II study of low-dose decitabine in patients with chronic myelogenous leukemia resistant to imatinib mesylate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.8.1035

DNA methylation of tumor suppressor genes in clinical remission predicts the relapse risk in acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.8.1035

Detection of methylation in promoter sequences by melting curve analysis-based semiquantitative real time PCR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.8.1035

MS-MLPA: an attractive alternative laboratory assay for robust, reliable, and semiquantitative detection of MGMT promoter hypermethylation in gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.12.8.1035

10.1517/14728222.12.8.1035

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18620524%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

1 reference