(Q59134749)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

title

TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

0 references

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

Geertrui Denecker

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

Christophe Van Neste

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

Carolina Nunes

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

Fanny De Vloed

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

Pauline Depuydt

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

Karen Verboom

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

Dries Rombaut

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

Siebe Loontiens

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

Jolien De Wyn

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

Anke H W Essing

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

Daniel Dreidax

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

Dieter Deforce

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

Filip Van Nieuwerburgh

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

Anton Henssen

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

Rogier Versteeg

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

Valentina Boeva

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

Gudrun Schleiermacher

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

Johan van Nes

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

Suzanne Vanhauwaert

28

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

Frank Speleman

33

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

author name string

Emmy M Dolman

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

Wouter Van Loocke

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

Moritz Gartlgruber

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

Waleed M Kholosy

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

Bianca Koopmans

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

Carl Herrmann

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

Kaat Durinck

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

Pieter Mestdagh

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

Johannes H Schulte

29

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

Frank Westermann

30

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

Jan J Molenaar

31

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

Katleen De Preter

32

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

language of work or name

English

0 references

publication date

19 November 2018

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

published in

Nature Communications

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

volume

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

page(s)

4866

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

4 May 2020

copyright license

start time

19 November 2018

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

Cytoscape

1 reference

9 June 2022

https://europepmc.org/search?query=(METHODS:'Cytoscape')

inferred from PubMed Central ID database lookup

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6242972/fullTextXML

inferred from PubMed Central ID database lookup

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/6242972

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/s41467-018-06699-9

0 references

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Genomic Amplifications and Distal 6q Loss: Novel Markers for Poor Survival in High-risk Neuroblastoma Patients.

30 November 2018

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30 November 2018

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30 November 2018

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30 November 2018

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Histone Deacetylase Inhibitors as Anticancer Drugs

30 November 2018

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30 November 2018

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30 November 2018

1 reference

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A Phase Separation Model for Transcriptional Control.

30 November 2018

1 reference

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Integration of mRNP formation and export

30 November 2018

1 reference

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Transcriptional Addiction in Cancer.

30 November 2018

1 reference

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Tbx2 regulates anterior neural specification by repressing FGF signaling pathway

30 November 2018

1 reference

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c-MYC partners with BPTF in human cancer.

30 November 2018

1 reference

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Integration of TP53, DREAM, MMB-FOXM1 and RB-E2F target gene analyses identifies cell cycle gene regulatory networks.

30 November 2018

1 reference

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30 November 2018

1 reference

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GATA3-dependent cellular reprogramming requires activation-domain dependent recruitment of a chromatin remodeler

30 November 2018

1 reference

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Models of human core transcriptional regulatory circuitries

30 November 2018

1 reference

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iRegulon and i-cisTarget: Reconstructing Regulatory Networks Using Motif and Track Enrichment

30 November 2018

1 reference

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Targeting MYCN-Driven Transcription By BET-Bromodomain Inhibition.

30 November 2018

1 reference

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Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism.

30 November 2018

1 reference

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Microphthalmia-associated transcription factor/T-box factor-2 axis acts through Cyclin D1 to regulate melanocyte proliferation.

30 November 2018

1 reference

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No driver behind the wheel? Targeting transcription in cancer.

30 November 2018

1 reference

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The p53-p21-DREAM-CDE/CHR pathway regulates G2/M cell cycle genes

30 November 2018

1 reference

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MYCN-driven regulatory mechanisms controlling LIN28B in neuroblastoma

30 November 2018

1 reference

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Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations

30 November 2018

1 reference

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Mutational dynamics between primary and relapse neuroblastomas.

30 November 2018

1 reference

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An in vivo screen identifies ependymoma oncogenes and tumor-suppressor genes.

30 November 2018

1 reference

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Somatic Cell Fusions Reveal Extensive Heterogeneity in Basal-like Breast Cancer.

30 November 2018

1 reference

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FourCSeq: analysis of 4C sequencing data

30 November 2018

1 reference

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Chromatin architecture reorganization during stem cell differentiation.

30 November 2018

1 reference

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An investigation of biomarkers derived from legacy microarray data for their utility in the RNA-seq era

30 November 2018

1 reference

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ATAC-seq: A Method for Assaying Chromatin Accessibility Genome-Wide

30 November 2018

1 reference

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ViVar: a comprehensive platform for the analysis and visualization of structural genomic variation

30 November 2018

1 reference

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CDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6242972

A Cre-conditional MYCN-driven neuroblastoma mouse model as an improved tool for preclinical studies.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6242972

T-box transcription factors in cancer biology

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6242972

Emergence of new ALK mutations at relapse of neuroblastoma

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6242972

Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6242972

Brd4 and HEXIM1: multiple roles in P-TEFb regulation and cancer

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6242972

TBX2 blocks myogenesis and promotes proliferation in rhabdomyosarcoma cells

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6242972

Super-enhancers in the control of cell identity and disease

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6242972

Targeting MYCN in neuroblastoma by BET bromodomain inhibition

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6242972

REST: an oncogene or a tumor suppressor?

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6242972

Focal DNA copy number changes in neuroblastoma target MYCN regulated genes

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6242972

LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6242972

Robust 4C-seq data analysis to screen for regulatory DNA interactions.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6242972

The T box transcription factor TBX2 promotes epithelial-mesenchymal transition and invasion of normal and malignant breast epithelial cells

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6242972

i-cisTarget: an integrative genomics method for the prediction of regulatory features and cis-regulatory modules

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6242972

Control-FREEC: a tool for assessing copy number and allelic content using next-generation sequencing data

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6242972

Induction of Id-1 by FGF-2 involves activity of EGR-1 and sensitizes neuroblastoma cells to cell death

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6242972

Meta-analysis of neuroblastomas reveals a skewed ALK mutation spectrum in tumors with MYCN amplification

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6242972

Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6242972

Transcriptional repression of SKP2 is impaired in MYCN-amplified neuroblastoma

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6242972

Cholinergic switch associated with morphological differentiation in neuroblastoma

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6242972

Regulation of BIRC5 and its isoform BIRC5-2B in neuroblastoma

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6242972

High Myc pathway activity and low stage of neuronal differentiation associate with poor outcome in neuroblastoma

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6242972

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6242972

Tbx2 is overexpressed and plays an important role in maintaining proliferation and suppression of senescence in melanomas

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6242972

Tbx2 directly represses the expression of the p21(WAF1) cyclin-dependent kinase inhibitor

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6242972

The role of the MEIS homeobox genes in neuroblastoma

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6242972

PPM1D is a potential target for 17q gain in neuroblastoma

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6242972

Signal transduction pathways through TRK-A and TRK-B receptors in human neuroblastoma cells

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6242972

Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6242972

The transcription factor dHAND is a downstream effector of BMPs in sympathetic neuron specification.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6242972

Conserved and divergent expression of T-box genes Tbx2-Tbx5 in Xenopus.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6242972

Physical interaction between CDK9 and B-Myb results in suppression of B-Myb gene autoregulation

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6242972

Genetic heterogeneity of neuroblastoma studied by comparative genomic hybridization.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6242972

Targeted expression of MYCN causes neuroblastoma in transgenic mice

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6242972

Activated expression of the N-myc gene in human neuroblastomas and related tumors

30 November 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41467-018-06699-9

7 January 2021

Gain of chromosome arm 17q and adverse outcome in patients with neuroblastoma

1 reference

https://api.crossref.org/works/10.1038%2FS41467-018-06699-9

7 January 2021

Molecular analysis of chromosome arm 17q gain in neuroblastoma

1 reference

https://api.crossref.org/works/10.1038%2FS41467-018-06699-9

7 January 2021

Frequent amplification of 8q24, 11q, 17q, and 20q-specific genes in pancreatic cancer

1 reference

https://api.crossref.org/works/10.1038%2FS41467-018-06699-9

7 January 2021

High incidence of DNA mutations and gene amplifications of theALKgene in advanced sporadic neuroblastoma tumours

1 reference

https://api.crossref.org/works/10.1038%2FS41467-018-06699-9

7 January 2021

https://pubmed.ncbi.nlm.nih.gov/30451831

1 reference

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/S41467-018-06699-9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30451831%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

1 reference