(Q59335643)

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Clemastine Alleviates Depressive-Like Behavior Through Reversing the Imbalance of Microglia-Related Pro-inflammatory State in Mouse Hippocampus

scientific article published on 13 November 2018

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Clemastine Alleviates Depressive-Like Behavior Through Reversing the Imbalance of Microglia-Related Pro-inflammatory State in Mouse Hippocampus (English)

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Europe PubMed Central

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5 May 2020

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5 May 2020

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Ting Zhang

2

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5 May 2020

Chun-Lei Jiang

3

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5 May 2020

Wei Wang

4

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2018

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Frontiers in Cellular Neuroscience

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5 May 2020

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5 May 2020

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Creative Commons Attribution 4.0 International

13 November 2018

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April 2022 Public Data File from Crossref

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6243034/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Microglia, macrophages, perivascular macrophages, and pericytes: a review of function and identification

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

based on heuristic

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Suppressed proliferation and apoptotic changes in the rat dentate gyrus after acute and chronic stress are reversible

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Astroglial plasticity in the hippocampus is affected by chronic psychosocial stress and concomitant fluoxetine treatment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gliogenesis and glial pathology in depression

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of neurogenesis and gliogenesis by stress and antidepressant treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Behavioral profile of P2X7 receptor knockout mice in animal models of depression and anxiety: relevance for neuropsychiatric disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglia: biology and pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clemastine potentiates the human P2X7 receptor by sensitizing it to lower ATP concentrations.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resilience and reduced c-Fos expression in P2X7 receptor knockout mice exposed to repeated forced swim test.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clemastine causes immune suppression through inhibition of extracellular signal-regulated kinase-dependent proinflammatory cytokines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Innate immunity in the central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation and depression

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

based on heuristic

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Swimming exercise ameliorates depression-like behavior in chronically stressed rats: relevant to proinflammatory cytokines and IDO activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

based on heuristic

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Neurochemical Changes in the Mouse Hippocampus Underlying the Antidepressant Effect of Genetic Deletion of P2X7 Receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglial NLRP3 inflammasome activation mediates IL-1β-related inflammation in prefrontal cortex of depressive rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

based on heuristic

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Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

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inferred from PubMed ID database lookup

Illness progression, recent stress, and morphometry of hippocampal subfields and medial prefrontal cortex in major depression

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

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Mental health: a world of depression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

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Clemastine Confers Neuroprotection and Induces an Anti-Inflammatory Phenotype in SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

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Inhibition of tumor necrosis factor improves sleep continuity in patients with treatment resistant depression and high inflammation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Minocycline treatment ameliorates interferon-alpha- induced neurogenic defects and depression-like behaviors in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Up-regulation of P2X7 receptors mediating proliferation of Schwann cells after sciatic nerve injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation and increased IDO in hippocampus contribute to depression-like behavior induced by estrogen deficiency.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clemastine rescues behavioral changes and enhances remyelination in the cuprizone mouse model of demyelination

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Depression as a microglial disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P2X7 as a new target for chrysophanol to treat lipopolysaccharide-induced depression in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Density of GFAP-immunoreactive astrocytes is decreased in left hippocampi in major depressive disorder

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clemastine Enhances Myelination in the Prefrontal Cortex and Rescues Behavioral Changes in Socially Isolated Mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of neuro-immunological factors in the pathophysiology of mood disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

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A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

based on heuristic

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Early P2X7R-related astrogliosis in autoimmune encephalomyelitis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

based on heuristic

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The microglial ATP-gated ion channel P2X7 as a CNS drug target

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Actions of the antihistaminergic clemastine on presymptomatic SOD1-G93A mice ameliorate ALS disease progression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

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P2X7 receptor-sensitivity of astrocytes and neurons in the substantia gelatinosa of organotypic spinal cord slices of the mouse depends on the length of the culture period.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

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inferred from PubMed ID database lookup

The P2X7 Receptor-Interleukin-1 Liaison.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

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Microglial recruitment of IL-1β-producing monocytes to brain endothelium causes stress-induced anxiety.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

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The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

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Effects of dexamethasone on purinergic signaling in murine mast cells: Selective suppression of P2X7 receptor expression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

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Antidiabetic drug glyburide modulates depressive-like behavior comorbid with insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglial activation mediates chronic mild stress-induced depressive- and anxiety-like behavior in adult rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycyrrhizic acid ameliorates the kynurenine pathway in association with its antidepressant effect.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglia Polarization and Endoplasmic Reticulum Stress in Chronic Social Defeat Stress Induced Depression Mouse.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A P2X7 receptor antagonist reverses behavioural alterations, microglial activation and neuroendocrine dysregulation in an unpredictable chronic mild stress (UCMS) model of depression in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

12 December 2020

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Neuropsychopharmacology of JNJ-55308942: evaluation of a clinical candidate targeting P2X7 ion channels in animal models of neuroinflammation and anhedonia

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

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Inhibition of MyD88 Signaling Skews Microglia/Macrophage Polarization and Attenuates Neuronal Apoptosis in the Hippocampus After Status Epilepticus in Mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

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Microglial signatures and their role in health and disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30483062

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Identifiers

10.3389/FNCEL.2018.00412

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30483062%20AND%20SRC:MED&resulttype=core&format=json

5 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30483062%20AND%20SRC:MED&resulttype=core&format=json

5 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30483062%20AND%20SRC:MED&resulttype=core&format=json

5 May 2020

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