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Microglial signatures and their role in health and disease
scientific article published on 01 October 2018
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scholarly article
1 reference
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Europe PubMed Central
PubMed publication ID
30206328
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30206328%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 April 2020
title
Microglial signatures and their role in health and disease
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
30206328
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30206328%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 April 2020
main subject
microglia
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inferred from title
author name string
Oleg Butovsky
series ordinal
1
1 reference
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Europe PubMed Central
PubMed publication ID
30206328
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30206328%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 April 2020
Howard L Weiner
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2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
30206328
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30206328%20AND%20SRC:MED&resulttype=core&format=json
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22 April 2020
publication date
1 October 2018
1 reference
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Europe PubMed Central
PubMed publication ID
30206328
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30206328%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 April 2020
published in
Nature Reviews Neuroscience
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Europe PubMed Central
PubMed publication ID
30206328
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30206328%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 April 2020
volume
19
1 reference
stated in
Europe PubMed Central
PubMed publication ID
30206328
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30206328%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 April 2020
issue
10
1 reference
stated in
Europe PubMed Central
PubMed publication ID
30206328
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30206328%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 April 2020
page(s)
622-635
1 reference
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Europe PubMed Central
PubMed publication ID
30206328
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30206328%20AND%20SRC:MED&resulttype=core&format=json
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22 April 2020
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Microglia: active sensor and versatile effector cells in the normal and pathologic brain
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Microglial Physiology and Pathophysiology: Insights from Genome-wide Transcriptional Profiling
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Peripheral monocytes are functionally altered and invade the CNS in ALS patients
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The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
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Siglec-H is a microglia-specific marker that discriminates microglia from CNS-associated macrophages and CNS-infiltrating monocytes
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Increased White Matter Inflammation in Aging- and Alzheimer's Disease Brain
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High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease.
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Microglial cell population dynamics in the injured adult central nervous system
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The role of microglia in the healthy brain.
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Microglial dynamics and role in the healthy and diseased brain: a paradigm of functional plasticity
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Microglia Function in Central Nervous System Development and Plasticity
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IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia
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Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1.
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Transcriptional control of granulocyte and monocyte development
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Zebrafish early macrophages colonize cephalic mesenchyme and developing brain, retina, and epidermis through a M-CSF receptor-dependent invasive process
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Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
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MAFB Determines Human Macrophage Anti-Inflammatory Polarization: Relevance for the Pathogenic Mechanisms Operating in Multicentric Carpotarsal Osteolysis.
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Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells
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Microglia development follows a stepwise program to regulate brain homeostasis.
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MafB antagonizes phenotypic alteration induced by GM-CSF in microglia.
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Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice.
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Sall1 regulates cortical neurogenesis and laminar fate specification in mice: implications for neural abnormalities in Townes-Brocks syndrome
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Sall1 is a transcriptional regulator defining microglia identity and function.
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Mice deficient in NRROS show abnormal microglial development and neurological disorders.
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TGF-β signaling regulates neuronal C1q expression and developmental synaptic refinement
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Phagocytic glial cells: sculpting synaptic circuits in the developing nervous system
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based on heuristic
inferred from DOI database lookup
Synaptic pruning by microglia is necessary for normal brain development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The classical complement cascade mediates CNS synapse elimination
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Complement and microglia mediate early synapse loss in Alzheimer mouse models.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Microglia: new roles for the synaptic stripper.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Neurotrophins regulate proliferation and survival of two microglial cell lines in vitro
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Brain microglia/macrophages express neurotrophins that selectively regulate microglial proliferation and function.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Brain-derived neurotrophic factor-dependent synaptic plasticity is suppressed by interleukin-1β via p38 mitogen-activated protein kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Infiltrating monocytes promote brain inflammation and exacerbate neuronal damage after status epilepticus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TAM receptors regulate multiple features of microglial physiology
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Microglia enhance neurogenesis and oligodendrogenesis in the early postnatal subventricular zone
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Fractalkine and CX 3 CR1 regulate hippocampal neurogenesis in adult and aged rats
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Microglia contribute to normal myelinogenesis and to oligodendrocyte progenitor maintenance during adulthood.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A novel microglial subset plays a key role in myelinogenesis in developing brain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Microglia activated by IL-4 or IFN-gamma differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
P2Y12 expression and function in alternatively activated human microglia.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Microglia-dependent alteration of glutamatergic synaptic transmission and plasticity in the hippocampus during peripheral inflammation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Dystrophic microglia in the aging human brain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Microglial senescence: does the brain's immune system have an expiration date?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evidence that aging and amyloid promote microglial cell senescence.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of a chronic non-neurodegenerative microglia activation state in a mouse model of peroxisomal β-oxidation deficiency.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Microglia and Alzheimer's disease pathogenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Microglia and neuroinflammation: a pathological perspective
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Variant of TREM2 Associated with the Risk of Alzheimer's Disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TREM2 Variants in Alzheimer's Disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evidence that the APOE locus influences rate of disease progression in late onset familial Alzheimer's Disease but is not causative
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: the Rotterdam Study
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ApoE-4 and age at onset of Alzheimer's disease: the NIMH genetics initiative.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of complement CR1 on brain amyloid burden during aging and its modification by APOE genotype
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transcriptional profiling of CD11c-positive microglia accumulating around amyloid plaques in a mouse model for Alzheimer's disease.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Untangling the brain's neuroinflammatory and neurodegenerative transcriptional responses
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Microglial Priming and Alzheimer's Disease: A Possible Role for (Early) Immune Challenges and Epigenetics?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Systemic infections and inflammation affect chronic neurodegeneration
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Neuroinflammation: implications for the pathogenesis and molecular diagnosis of Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Neuroinflammation in Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Neurotoxic reactive astrocytes are induced by activated microglia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Iron and neurodegeneration in the multiple sclerosis brain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Slow expansion of multiple sclerosis iron rim lesions: pathology and 7 T magnetic resonance imaging
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Minocycline selectively inhibits M1 polarization of microglia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Minocycline attenuates microglial activation but fails to mitigate striatal dopaminergic neurotoxicity: role of tumor necrosis factor- alpha
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Adalimumab for Uveitis in Juvenile Idiopathic Arthritis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
α-Synuclein vaccination prevents the accumulation of parkinson disease-like pathologic inclusions in striatum in association with regulatory T cell recruitment in a rat model
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Microglial phenotypes in Parkinson's disease and animal models of the disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Imaging Striatal Microglial Activation in Patients with Parkinson's Disease.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer's Disease Not Evident in Mouse Models
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The TREM receptor family and signal integration
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Blockade of TREM-2 exacerbates experimental autoimmune encephalomyelitis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evidence of trem2 variant associated with triple risk of Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TREM2 is associated with increased risk for Alzheimer's disease in African Americans
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer's disease.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of microglial proliferation during chronic neurodegeneration
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Colony-stimulating factor 1 receptor signaling is necessary for microglia viability, unmasking a microglia progenitor cell in the adult brain.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer's-like pathology
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Microglial activation and its implications in the brain diseases.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular targets of non-steroidal anti-inflammatory drugs in neurodegenerative diseases.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Anti-ApoE antibody given after plaque onset decreases Aβ accumulation and improves brain function in a mouse model of Aβ amyloidosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Method for widespread microRNA-155 inhibition prolongs survival in ALS-model mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α-PU.1 pathway.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Environmental Enrichment Potently Prevents Microglia-Mediated Neuroinflammation by Human Amyloid β-Protein Oligomers
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Host microbiota constantly control maturation and function of microglia in the CNS.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Gut microbiome alterations in Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Alterations of the human gut microbiome in multiple sclerosis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MRI in multiple sclerosis: current status and future prospects
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Brain imaging in Alzheimer disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Two-photon imaging of microglia in the mouse cortex in vivo.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Translocator Protein-18 kDa (TSPO) Positron Emission Tomography (PET) Imaging and Its Clinical Impact in Neurodegenerative Diseases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Microglial activation in Parkinson's disease using [18F]-FEPPA.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular Imaging of Neuroinflammation in Neurodegenerative Dementias: The Role of In Vivo PET Imaging
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Early and protective microglial activation in Alzheimer's disease: a prospective study using 18F-DPA-714 PET imaging.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Imaging of microglia in patients with neurodegenerative disorders
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Increase of TREM2 during Aging of an Alzheimer's Disease Mouse Model Is Paralleled by Microglial Activation and Amyloidosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ontogeny and homeostasis of CNS myeloid cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A lineage of myeloid cells independent of Myb and hematopoietic stem cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Factors regulating microglia activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The adenosine generating enzymes CD39/CD73 control microglial processes ramification in the mouse brain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Disruption of the ATP/adenosine balance in CD39-/- mice is associated with handling-induced seizures.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A Combination of Ontogeny and CNS Environment Establishes Microglial Identity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41583-018-0057-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/S41583-018-0057-5
1 reference
stated in
Europe PubMed Central
PubMed publication ID
30206328
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30206328%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 April 2020
PMC publication ID
7255106
0 references
PubMed publication ID
30206328
1 reference
stated in
Europe PubMed Central
PubMed publication ID
30206328
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30206328%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 April 2020
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