(Q47568641)

4 February 2018

title

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases. (English)

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4 February 2018

0 references

1 reference

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25

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4 February 2018

Tsuneya Ikezu

30

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Hans Lassmann

34

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4 February 2018

Christian Haass

37

Christian Haass

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Tobias Zrzavy

Tobias Zrzavy

15

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Lien Beckers

Lien Beckers

7

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Jordi Ochando

Jordi Ochando

36

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David M. Holtzman

33

David M Holtzman

1 reference

4 February 2018

Rachid El Fatimy

6

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Howard L. Weiner

35

Howard L Weiner

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4 February 2018

Charlotte Madore

2

Charlotte Madore

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4 February 2018

author name string

Susanne Krasemann

1

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4 February 2018

Ron Cialic

3

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4 February 2018

Caroline Baufeld

4

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Narghes Calcagno

5

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4 February 2018

Elaine O'Loughlin

8

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4 February 2018

Yang Xu

9

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4 February 2018

Zain Fanek

10

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David J Greco

11

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Scott T Smith

12

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4 February 2018

George Tweet

13

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4 February 2018

Zachary Humulock

14

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4 February 2018

Patricia Conde-Sanroman

16

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4 February 2018

Mar Gacias

17

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4 February 2018

Zhiping Weng

18

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4 February 2018

Hao Chen

19

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4 February 2018

Emily Tjon

20

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4 February 2018

Fargol Mazaheri

21

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4 February 2018

Kristin Hartmann

22

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4 February 2018

Asaf Madi

23

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4 February 2018

Jason D Ulrich

24

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4 February 2018

Anna Worthmann

26

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4 February 2018

Joerg Heeren

27

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Bogdan Budnik

28

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Cynthia Lemere

29

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Frank L Heppner

31

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Vladimir Litvak

32

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4 February 2018

Oleg Butovsky

38

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4 February 2018

language of work or name

English

0 references

publication date

1 September 2017

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4 February 2018

published in

Immunity

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4 February 2018

volume

47

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4 February 2018

page(s)

566-581.e9

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4 February 2018

issue

3

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4 February 2018

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5719893/fullTextXML

inferred from PubMed Central ID database lookup

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/5719893

inferred from PubMed Central ID database lookup

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TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury.

29 September 2018

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A new fate mapping system reveals context-dependent random or clonal expansion of microglia

29 September 2018

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ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion

29 September 2018

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Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease.

29 September 2018

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Early changes in CSF sTREM2 in dominantly inherited Alzheimer's disease occur after amyloid deposition and neuronal injury

29 September 2018

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29 September 2018

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29 September 2018

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TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

29 September 2018

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Genetic Dissection of Tissue-Specific Apolipoprotein E Function for Hypercholesterolemia and Diet-Induced Obesity

29 September 2018

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CD33 modulates TREM2: convergence of Alzheimer loci.

29 September 2018

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Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2).

29 September 2018

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TMEM119 marks a subset of microglia in the human brain

29 September 2018

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Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis.

29 September 2018

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29 September 2018

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TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.

29 September 2018

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TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model

29 September 2018

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Environment drives selection and function of enhancers controlling tissue-specific macrophage identities

29 September 2018

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Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment.

29 September 2018

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Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice.

29 September 2018

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The miR-155-PU.1 axis acts on Pax5 to enable efficient terminal B cell differentiation

29 September 2018

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Apolipoprotein E mediation of neuro-inflammation in a murine model of multiple sclerosis

29 September 2018

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The M1 and M2 paradigm of macrophage activation: time for reassessment

29 September 2018

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Microglial priming in neurodegenerative disease

29 September 2018

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CSF Apo-E levels associate with cognitive decline and MRI changes

29 September 2018

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Identification of a unique TGF-β-dependent molecular and functional signature in microglia

29 September 2018

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The kainic acid model of temporal lobe epilepsy

29 September 2018

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The microglial sensome revealed by direct RNA sequencing

29 September 2018

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29 September 2018

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Acute isolation and transcriptome characterization of cortical astrocytes and microglia from young and aged mice

29 September 2018

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A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model

29 September 2018

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Peroxisomal multifunctional protein-2 deficiency causes neuroinflammation and degeneration of Purkinje cells independent of very long chain fatty acid accumulation

29 September 2018

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TREM2 Variants in Alzheimer's Disease

29 September 2018

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Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis

29 September 2018

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Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

29 September 2018

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Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS.

29 September 2018

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Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

29 September 2018

1 reference

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miR-155 inhibits expression of the MEF2A protein to repress skeletal muscle differentiation

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5719893

Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5719893

Microglia and microglia-like cell differentiated from DC inhibit CD4 T cell proliferation

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5719893

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's disease

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5719893

Various dendritic abnormalities are associated with fibrillar amyloid deposits in Alzheimer's disease.

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5719893

Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5719893

Onset and progression in inherited ALS determined by motor neurons and microglia

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5719893

Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus.

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5719893

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5719893

Apoptosis in neurodegenerative disorders

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5719893

Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease. Evidence for apoptotic cell death.

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5719893

Caspase dependent DNA fragmentation might be associated with excitotoxicity in Alzheimer disease

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5719893

Evidence for synaptic apoptosis.

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5719893

Programmed cell death in animal development

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5719893

Microglia: a sensor for pathological events in the CNS

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5719893

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5719893

The cortical neuritic dystrophy of Alzheimer's disease: nature, significance, and possible pathogenesis

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5719893

Aberrant neurofilament phosphorylation in Alzheimer disease

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5719893

Alzheimer's disease. A double-labeling immunohistochemical study of senile plaques

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5719893

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5719893

Cutting Edge: TREM-2 Attenuates Macrophage Activation

1 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28930663

12 December 2020

inferred from PubMed ID database lookup

Bcl-2: prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28930663

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1016/J.IMMUNI.2017.08.008

1 reference

4 February 2018

0 references

1 reference

4 February 2018