(Q48348638)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566429%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

title

Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566429%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

main subject

complement 3 deficiency

1 reference

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566429%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

Saba Chowdhury

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566429%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

Rong Ma

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566429%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

Kevin X Le

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566429%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

Soyon Hong

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566429%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

Beth Stevens

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566429%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

Cynthia A Lemere

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566429%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

author name string

Barbara J Caldarone

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566429%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

language of work or name

English

0 references

publication date

1 May 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566429%20AND%20SRC:MED&resulttype=core&format=json

Science Translational Medicine

21 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566429%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

volume

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566429%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

issue

392

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566429%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

cites work

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1 reference

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The classical complement cascade mediates CNS synapse elimination

21 January 2018

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Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner

21 January 2018

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TGF-β signaling regulates neuronal C1q expression and developmental synaptic refinement

21 January 2018

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Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline.

21 January 2018

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Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

21 January 2018

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Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity.

21 January 2018

1 reference

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Temporal accrual of complement proteins in amyloid plaques in Down's syndrome with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Distribution pattern and functional state of complement proteins and alpha 1-antichymotrypsin in cerebral beta/A4 deposits in Alzheimer's disease

21 January 2018

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Complement and microglia mediate early synapse loss in Alzheimer mouse models.

21 January 2018

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Histological and direct evidence for the role of complement in the neuroinflammation of AD.

21 January 2018

1 reference

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Complement in Alzheimer's disease: opportunities for modulating protective and pathogenic events

21 January 2018

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Synthetic Alzheimer amyloid beta/A4 peptides enhance production of complement C3 component by cultured microglial cells.

21 January 2018

1 reference

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NFκB-activated astroglial release of complement C3 compromises neuronal morphology and function associated with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease.

21 January 2018

1 reference

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Induction of complement proteins in a mouse model for cerebral microvascular A beta deposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Complement C3 and C4 expression in C1q sufficient and deficient mouse models of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Expression of complement system components during aging and amyloid deposition in APP transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

The role of complement and activated microglia in the pathogenesis of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Aβ by microglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice

21 January 2018

1 reference

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Absence of C1q leads to less neuropathology in transgenic mouse models of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Hippocampus-dependent place learning enables spatial flexibility in C57BL6/N mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Inflammation and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Synaptic changes in the dentate gyrus of APP/PS1 transgenic mice revealed by electron microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Synaptic contact number and size in stratum radiatum CA1 of APP/PS1DeltaE9 transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

A dramatic increase of C1q protein in the CNS during normal aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Altered cognitive performance and synaptic function in the hippocampus of mice lacking C3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Inflammation in Alzheimer's disease: Lessons learned from microglia-depletion models

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer's-like pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

C1q propagates microglial activation and neurodegeneration in the visual axis following retinal ischemia/reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Complement receptor 3 (CD11b/CD18) is implicated in the elimination of β-amyloid peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Alzheimer's disease is a synaptic failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Widespread changes in dendritic spines in a model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Complement inhibition promotes endogenous neurogenesis and sustained anti-inflammatory neuroprotection following reperfused stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

A Commentary On: "NFκB-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer's Disease". A cautionary note regarding C3aR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Over expression of amyloid beta-protein reduces the number of neurons in the striatum of APPswe/PS1DeltaE9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Amyloid precursor protein increases cortical neuron size in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Aging causes partial loss of basal forebrain but no loss of pontine reticular cholinergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Complement activation by beta-amyloid in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Microglial activation in early stages of amyloid beta protein deposition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Multivalent binding of complement protein C1Q to the amyloid beta-peptide (A beta) promotes the nucleation phase of A beta aggregation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Microglial priming in neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Neurodegeneration by activation of the microglial complement-phagosome pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

C3-dependent mechanism of microglial priming relevant to multiple sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Deficiency of complement receptors CR2/CR1 in Cr2⁻/⁻ mice reduces the extent of secondary brain damage after closed head injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Reduced removal of synaptic terminals from axotomized spinal motoneurons in the absence of complement C3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Molecular signatures of neurodegeneration in the cortex of PS1/PS2 double knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Studies of group B streptococcal infection in mice deficient in complement component C3 or C4 demonstrate an essential role for complement in both innate and acquired immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Quantifying synapses: an immunocytochemistry-based assay to quantify synapse number

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

Unbiased stereological estimation of the number of neurons in the human hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

A quantitative spatiotemporal analysis of microglia morphology during ischemic stroke and reperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAF6295

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28566429

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Selectively reduced expression of synaptic plasticity-related genes in amyloid precursor protein + presenilin-1 transgenic mice.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28566429

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Complement C1q does not bind monomeric beta-amyloid

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28566429

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCITRANSLMED.AAF6295

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566429%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566429%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

PubMed publication ID

28566429

1 reference