(Q59516123)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25255859%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

title

Systemic autophagy insufficiency compromises adaptation to metabolic stress and facilitates progression from obesity to diabetes (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25255859%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

0 references

1 reference

7

1 reference

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20 February 2020

Seung-Hoi Koo

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25255859%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

Masaaki Komatsu

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25255859%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

author name string

Yu-Mi Lim

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25255859%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

Hyejin Lim

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25255859%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

Kyu Yeon Hur

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25255859%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

Wenying Quan

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25255859%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

Hae-Youn Lee

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25255859%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

Hwanju Cheon

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25255859%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

Hong Lim Kim

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25255859%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

Jin Kim

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25255859%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

Myung-Shik Lee

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25255859%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

language of work or name

English

0 references

publication date

26 September 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25255859%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

published in

Nature Communications

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25255859%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

volume

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25255859%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

issue

1

0 references

page(s)

4934

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25255859%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/ncomms5934

20 February 2020

exact match

0 references

cites work

Amino Acids and Insulin Control Autophagic Proteolysis through Different Signaling Pathways in Relation to mTOR in Isolated Rat Hepatocytes

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Role of calcium in pancreatic islet cell death by IFN-gamma/TNF-alpha

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Mitochondrial dysfunction in the elderly: possible role in insulin resistance

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance.

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Overexpression of Atg5 in mice activates autophagy and extends lifespan

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Guidelines for the use and interpretation of assays for monitoring autophagy

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

The roles of intracellular protein-degradation pathways in neurodegeneration

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Imatinib mesylate reduces endoplasmic reticulum stress and induces remission of diabetes in db/db mice

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Autophagy suppresses tumorigenesis through elimination of p62

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Comprehensive proteomics analysis of autophagy-deficient mouse liver

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

A crucial role for adipose tissue p53 in the regulation of insulin resistance

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

p53 Activation in Adipocytes of Obese Mice

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Autophagy regulates lipid metabolism

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell size

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

A role for mitochondria in NLRP3 inflammasome activation

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Adipocyte death, adipose tissue remodeling, and obesity complications

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

https://api.crossref.org/works/10.1038%2FNCOMMS5934

1 reference

7 January 2021

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Autophagy inhibition and antimalarials promote cell death in gastrointestinal stromal tumor (GIST).

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Altered lipid content inhibits autophagic vesicular fusion

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

LC3, a microtubule-associated protein1A/B light chain3, is involved in cytoplasmic lipid droplet formation

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Autophagy deficiency in beta cells leads to compromised unfolded protein response and progression from obesity to diabetes in mice

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Autophagy deficiency by hepatic FIP200 deletion uncouples steatosis from liver injury in NAFLD.

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Loss of autophagy in pro-opiomelanocortin neurons perturbs axon growth and causes metabolic dysregulation

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Loss of autophagy in hypothalamic POMC neurons impairs lipolysis

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Role of hypothalamic proopiomelanocortin neuron autophagy in the control of appetite and leptin response

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation.

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Endoplasmic reticulum stress triggers autophagy

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

The anticancer drug imatinib induces cellular autophagy.

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Novel regulation of parkin function through c-Abl-mediated tyrosine phosphorylation: implications for Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Inhibition of autophagy at a late stage enhances imatinib-induced cytotoxicity in human malignant glioma cells

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Imatinib mesilate-induced phosphatidylinositol 3-kinase signalling and improved survival in insulin-producing cells: role of Src homology 2-containing inositol 5'-phosphatase interaction with c-Abl

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

C-Kit controls IL-1β-induced effector functions in HMC-cells

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Amyloidogenic peptide oligomer accumulation in autophagy-deficient β cells induces diabetes

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Understanding oral glucose tolerance: comparison of glucose or insulin measurements during the oral glucose tolerance test with specific measurements of insulin resistance and insulin secretion.

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Lysophosphatidylcholine as an effector of fatty acid-induced insulin resistance

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Resistance of mitochondrial DNA-depleted cells against cell death: role of mitochondrial superoxide dismutase

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Cellular aging of mitochondrial DNA-depleted cells

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Apoptosis of pancreatic beta-cells detected in accelerated diabetes of NOD mice: no role of Fas-Fas ligand interaction in autoimmune diabetes

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021

Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5934

7 January 2021