(Q60195800)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10322126%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

title

Structure-based discovery and in-parallel optimization of novel competitive inhibitors of thymidylate synthase (English)

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7 December 2019

1

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7 December 2019

Maria Paola Costi

3

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7 December 2019

Daniel Watterson

4

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7 December 2019

author name string

Slomczynska U

2

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7 December 2019

Ghelli S

5

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7 December 2019

Shoichet BK

6

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7 December 2019

publication date

1 May 1999

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7 December 2019

published in

Chemistry and Biology

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7 December 2019

volume

6

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7 December 2019

issue

5

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7 December 2019

page(s)

319-331

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Design of enzyme inhibitors using iterative protein crystallographic analysis

7 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980077-5

7 January 2021

The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980077-5

7 January 2021

Structure-based design of inhibitors of purine nucleoside phosphorylase. 1. 9-(arylmethyl) derivatives of 9-deazaguanine

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980077-5

7 January 2021

Rational design of potent sialidase-based inhibitors of influenza virus replication

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980077-5

7 January 2021

Structure-based design and combinatorial chemistry yield low nanomolar inhibitors of cathepsin D.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980077-5

7 January 2021

Discovery and development of the novel potent orally active thrombin inhibitor N-(9-hydroxy-9-fluorenecarboxy)prolyl trans-4-aminocyclohexylmethyl amide (L-372,460): coapplication of structure-based design and rapid multiple analogue synthesis on so

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980077-5

7 January 2021

Discovery of nanomolar ligands for 7-transmembrane G-protein-coupled receptors from a diverse N-(substituted)glycine peptoid library

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980077-5

7 January 2021

Selection of Heregulin Variants Having Higher Affinity for the ErbB3 Receptor by Monovalent Phage Display

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980077-5

7 January 2021

Antibiotic sensitization using biphenyl tetrazoles as potent inhibitors of Bacteroides fragilis metallo-beta-lactamase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980077-5

7 January 2021

An example of a protein ligand found by database mining: description of the docking method and its verification by a 2.3 A X-ray structure of a thrombin-ligand complex

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980077-5

7 January 2021

Design and synthesis of novel 6,7-imidazotetrahydroquinoline inhibitors of thymidylate synthase using iterative protein crystal structure analysis

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980077-5

7 January 2021

Structure-based drug design: progress, results and challenges

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980077-5

7 January 2021

Structure-based design of lipophilic quinazoline inhibitors of thymidylate synthase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980077-5

7 January 2021

The art and practice of structure-based drug design: A molecular modeling perspective

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980077-5

7 January 2021

High resolution structures of HIV-1 RT from four RT-inhibitor complexes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980077-5

7 January 2021

Structure-based discovery of inhibitors of thymidylate synthase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980077-5

7 January 2021

Molecular basis of crossreactivity and the limits of antibody-antigen complementarity

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980077-5

7 January 2021

Structural analysis of antiviral agents that interact with the capsid of human rhinoviruses

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980077-5

7 January 2021

Comparison of crystal and solution hemoglobin binding of selected antigelling agents and allosteric modifiers

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980077-5

7 January 2021

The structure of a complex between the NC10 antibody and influenza virus neuraminidase and comparison with the overlapping binding site of the NC41 antibody

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980077-5

7 January 2021

Analogous inhibitors of elastase do not always bind analogously

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980077-5

7 January 2021

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980077-5

1 reference

7 January 2021

Inhibition of the fusion-inducing conformational change of influenza hemagglutinin by benzoquinones and hydroquinones

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980077-5

7 January 2021

Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980077-5

7 January 2021

Automated docking with grid-based energy evaluation

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980077-5

7 January 2021

Ligand solvation in molecular docking

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980077-5

7 January 2021

Calculating log Poct from structures

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980077-5

7 January 2021

Binding of amino acid side-chains to S1 cavities of serine proteinases

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980077-5

7 January 2021

2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines as nonclassical antifolate inhibitors of thymidylate synthase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980077-5

7 January 2021

Thymidylate synthase inhibition: A structure-based rationale for drug design

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980077-5

7 January 2021

Predicting the structure of protein complexes: a step in the right direction

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980077-5

7 January 2021

Molecular docking programs successfully predict the binding of a beta-lactamase inhibitory protein to TEM-1 beta-lactamase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980077-5

7 January 2021

Structure-based design of inhibitors specific for bacterial thymidylate synthase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980077-5

7 January 2021

Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980077-5

7 January 2021

Exclusion of 2'-deoxycytidine 5'-monophosphate by asparagine 229 of thymidylate synthase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980077-5

7 January 2021

Crystal structure and ligand-binding studies of a screened peptide complexed with streptavidin

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980077-5

7 January 2021

Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of alzheimer's amyloid β‐protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): Engineering of inhibitors with altered specificities

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980077-5

7 January 2021

Molecular docking using shape descriptors

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980077-5

7 January 2021

Orientational sampling and rigid-body minimization in molecular docking

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980077-5

7 January 2021

Calculation of electrostatic potentials in an enzyme active site

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980077-5

7 January 2021

Structure-based enhancement of boronic acid-based inhibitors of AmpC beta-lactamase.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2899%2980077-5

7 January 2021

10.1016/S1074-5521(99)80077-5

Identifiers

DOI

1 reference

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7 December 2019

1 reference