(Q60502259)

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4 April 2020

editorial

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title

The Ecstasy and Agony of Assay Interference Compounds (English)

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4 April 2020

1

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4 April 2020

Carolyn Bertozzi

2

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4 April 2020

3

Gunda I. Georg

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4 April 2020

Laura Lee Kiessling

4

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4 April 2020

Craig W. Lindsley

5

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4 April 2020

6

Dennis Liotta

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4 April 2020

Kenneth M. Merz Jr.

7

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4 April 2020

8

Alanna Schepartz

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4 April 2020

9

Shaomeng Wang

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4 April 2020

author name string

Kenneth M. Merz

7

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publication date

28 February 2017

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4 April 2020

published in

ACS Infectious Diseases

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4 April 2020

volume

3

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4 April 2020

issue

4

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4 April 2020

page(s)

259-262

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Can Invalid Bioactives Undermine Natural Product-Based Drug Discovery?

4 April 2020

cites work

1 reference

30 November 2021

https://opencitations.net/index/coci/api/v1/citations/10.1021/ACS.JMEDCHEM.5B01009

Badapple: promiscuity patterns from noisy evidence

1 reference

COCI

https://opencitations.net/index/coci/api/v1/citations/10.1186/S13321-016-0137-3

Novel Broad Spectrum Inhibitors Targeting the Flavivirus Methyltransferase

3 January 2022

1 reference

5 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/ACSINFECDIS.7B00023

Fluorescence spectroscopic profiling of compound libraries

1 reference

5 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/ACSINFECDIS.7B00023

A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

1 reference

5 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/ACSINFECDIS.7B00023

Small-molecule activators of a proenzyme

1 reference

5 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/ACSINFECDIS.7B00023

Observations on screening-based research and some concerning trends in the literature

1 reference

5 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/ACSINFECDIS.7B00023

Phytochemicals perturb membranes and promiscuously alter protein function.

1 reference

5 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/ACSINFECDIS.7B00023

Chemistry: Chemical con artists foil drug discovery

1 reference

5 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/ACSINFECDIS.7B00023

New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays

1 reference

5 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/ACSINFECDIS.7B00023

Nonleadlikeness and leadlikeness in biochemical screening

1 reference

5 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/ACSINFECDIS.7B00023

Pan Assay Interference Compounds (PAINS) and Other Promiscuous Compounds in Antifungal Research

1 reference

5 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/ACSINFECDIS.7B00023

Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease

1 reference

5 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/ACSINFECDIS.7B00023

High-throughput assays for promiscuous inhibitors.

1 reference

5 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/ACSINFECDIS.7B00023

Apparent activity in high-throughput screening: origins of compound-dependent assay interference

1 reference

5 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/ACSINFECDIS.7B00023

A detergent-based assay for the detection of promiscuous inhibitors

1 reference

5 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/ACSINFECDIS.7B00023

Structure-based discovery of an immunomodulatory inhibitor of TLR1-TLR2 heterodimerization from a natural product-like database

1 reference

5 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/ACSINFECDIS.7B00023

Fluorescence polarization assays in small molecule screening

1 reference

5 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/ACSINFECDIS.7B00023

Chemical probes of UDP-galactopyranose mutase

1 reference

5 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/ACSINFECDIS.7B00023

Screening-based translation of public research encounters painful problems

1 reference

5 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/ACSINFECDIS.7B00023

Small molecule inhibitors of HIVgp41 N-heptad repeat trimer formation

1 reference

5 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/ACSINFECDIS.7B00023

Stoichiometry and physical chemistry of promiscuous aggregate-based inhibitors

1 reference

5 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/ACSINFECDIS.7B00023

Firefly Luciferase in Chemical Biology: A Compendium of Inhibitors, Mechanistic Evaluation of Chemotypes, and Suggested Use As a Reporter

1 reference

5 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/ACSINFECDIS.7B00023

Colloidal aggregation causes inhibition of G protein-coupled receptors

1 reference

5 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/ACSINFECDIS.7B00023

Interpreting steep dose-response curves in early inhibitor discovery

1 reference

5 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/ACSINFECDIS.7B00023

Degradation of Curcumin: From Mechanism to Biological Implications

1 reference

5 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/ACSINFECDIS.7B00023

An Aggregation Advisor for Ligand Discovery.

1 reference

5 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/ACSINFECDIS.7B00023

Metrics other than potency reveal systematic variation in responses to cancer drugs.

1 reference

5 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/ACSINFECDIS.7B00023

Divergent modes of enzyme inhibition in a homologous structure-activity series

1 reference

5 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/ACSINFECDIS.7B00023

Structure-based virtual screening approach to the discovery of novel PTPMT1 phosphatase inhibitors.

1 reference

5 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/ACSINFECDIS.7B00023

A high-throughput screen for aggregation-based inhibition in a large compound library

1 reference

5 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/ACSINFECDIS.7B00023

Designing screens: how to make your hits a hit.

1 reference

5 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/ACSINFECDIS.7B00023

The promise and peril of chemical probes

1 reference

5 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/ACSINFECDIS.7B00023

Screening in a spirit haunted world

1 reference

5 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/ACSINFECDIS.7B00023

Discovery of a Selective Aurora A Kinase Inhibitor by Virtual Screening

1 reference

5 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/ACSINFECDIS.7B00023

Comprehensive Mechanistic Analysis of Hits from High-Throughput and Docking Screens against β-Lactamase

1 reference

5 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/ACSINFECDIS.7B00023

How to Triage PAINS-Full Research

1 reference

5 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/ACSINFECDIS.7B00023

Colloidal aggregation affects the efficacy of anticancer drugs in cell culture

1 reference

5 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/ACSINFECDIS.7B00023

Feeling Nature's PAINS: Natural Products, Natural Product Drugs, and Pan Assay Interference Compounds (PAINS).

1 reference

5 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/ACSINFECDIS.7B00023

Pharmacophore identification, virtual screening and biological evaluation of prenylated flavonoids derivatives as PKB/Akt1 inhibitors

1 reference

5 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/ACSINFECDIS.7B00023

Identifiers

DOI

10.1021/ACSINFECDIS.7B00023

1 reference

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4 April 2020

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