(Q60920170)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30621321%20AND%20SRC:MED&resulttype=core&format=json

18 April 2020

1 reference

16 September 2022

Cdc42: A Novel Regulator of Insulin Secretion and Diabetes-Associated Diseases (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30621321%20AND%20SRC:MED&resulttype=core&format=json

18 April 2020

2 references

28 September 2019

20 November 2019

1 reference

28 September 2019

1 reference

20 November 2019

1 reference

3

1 reference

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18 April 2020

Lin-Chen Lv

4

1 reference

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18 April 2020

Jun Li

5

1 reference

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18 April 2020

Li-Xia Xiong

8

1 reference

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18 April 2020

author name string

Qi-Yuan Huang

1

1 reference

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18 April 2020

Xing-Ning Lai

2

1 reference

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18 April 2020

Jing Duan

6

1 reference

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18 April 2020

Xing-Hua Xiao

7

1 reference

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18 April 2020

Xian-Ling Qian

3

0 references

Lin-Chen Lv

4

0 references

Jun Li

5

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Li-Xia Xiong

8

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language of work or name

English

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publication date

6 January 2019

4 references

28 September 2019

20 November 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30621321%20AND%20SRC:MED&resulttype=core&format=json

18 April 2020

16 September 2022

January 2019

0 references

full work available at URL

https://www.mdpi.com/1422-0067/20/1/179

0 references

published in

International Journal of Molecular Sciences

4 references

28 September 2019

20 November 2019

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18 April 2020

16 September 2022

20

1 reference

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18 April 2020

issue

1

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Creative Commons Attribution

18 April 2020

page(s)

179

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copyright license

3 references

28 September 2019

20 November 2019

16 September 2022

0 references

Single Calcium Channel Activity in Mouse Pancreatic ?-Cells

1 reference

12 December 2020

Insulin and insulin-like growth factor I both stimulate metabolism, growth, and differentiation in the postneurula chick embryo.

1 reference

12 December 2020

Intracellular ATP directly blocks K+ channels in pancreatic B-cells

1 reference

12 December 2020

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1 reference

12 December 2020

Mechanism of compensatory hyperinsulinemia in normoglycemic insulin-resistant spontaneously hypertensive rats. Augmented enzymatic activity of glucokinase in beta-cells

1 reference

12 December 2020

Glucose- and GTP-dependent stimulation of the carboxyl methylation of CDC42 in rodent and human pancreatic islets and pure beta cells. Evidence for an essential role of GTP-binding proteins in nutrient-induced insulin secretion

1 reference

12 December 2020

Hypoglycemia in the Diabetes Control and Complications Trial. The Diabetes Control and Complications Trial Research Group

1 reference

12 December 2020

Regulation of podocyte structure during the development of nephrotic syndrome

1 reference

12 December 2020

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

1 reference

12 December 2020

Molecular basis of insulin-stimulated GLUT4 vesicle trafficking. Location! Location! Location!

1 reference

12 December 2020

G alpha-q/11 protein plays a key role in insulin-induced glucose transport in 3T3-L1 adipocytes

1 reference

12 December 2020

Gene 33/Mig-6, a transcriptionally inducible adapter protein that binds GTP-Cdc42 and activates SAPK/JNK. A potential marker transcript for chronic pathologic conditions, such as diabetic nephropathy. Possible role in the response to persistent stre

1 reference

12 December 2020

Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases

1 reference

12 December 2020

High-fat diet-induced muscle insulin resistance: relationship to visceral fat mass

1 reference

12 December 2020

Insulin-stimulated GLUT4 translocation in adipocytes is dependent upon cortical actin remodeling

1 reference

12 December 2020

History of diabetes from remote to recent times

1 reference

12 December 2020

Activation of rac and cdc42 video imaged by fluorescent resonance energy transfer-based single-molecule probes in the membrane of living cells

1 reference

12 December 2020

A central role for JNK in obesity and insulin resistance

1 reference

12 December 2020

Rho GTPases in cell biology

1 reference

12 December 2020

Cell biology of the glomerular podocyte

1 reference

12 December 2020

Cdc42 is a Rho GTPase family member that can mediate insulin signaling to glucose transport in 3T3-L1 adipocytes

1 reference

12 December 2020

Glucose regulates the cortical actin network through modulation of Cdc42 cycling to stimulate insulin secretion

1 reference

12 December 2020

Identification of an IQGAP1/AKAP79 complex in beta-cells

1 reference

12 December 2020

Insulin down-regulates insulin receptor substrate-2 expression through the phosphatidylinositol 3-kinase/Akt pathway

1 reference

12 December 2020

GRK2 is an endogenous protein inhibitor of the insulin signaling pathway for glucose transport stimulation

1 reference

12 December 2020

Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex

1 reference

12 December 2020

Connective tissue growth factor [CTGF]/CCN2 stimulates mesangial cell migration through integrated dissolution of focal adhesion complexes and activation of cell polarization.

1 reference

12 December 2020

Relationship between visceral adiposity and intramyocellular lipid content in two rat models of insulin resistance

1 reference

12 December 2020

Increased serum leptin protects from adiposity despite the increased glucose uptake in white adipose tissue in mice lacking p85alpha phosphoinositide 3-kinase

1 reference

12 December 2020

Regulation of Gene33 expression by insulin requires MEK-ERK activation

1 reference

12 December 2020

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

1 reference

12 December 2020

G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes

1 reference

12 December 2020

Insulin signaling and the regulation of glucose transport.

1 reference

12 December 2020

Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy

1 reference

12 December 2020

Tissue-specific roles of IRS proteins in insulin signaling and glucose transport

1 reference

12 December 2020

Insulin signaling in human visceral and subcutaneous adipose tissue in vivo

1 reference

12 December 2020

Loss of cortical actin filaments in insulin-resistant skeletal muscle cells impairs GLUT4 vesicle trafficking and glucose transport

1 reference

12 December 2020

Intersectin-1L nucleotide exchange factor regulates secretory granule exocytosis by activating Cdc42

1 reference

12 December 2020

Cool-1 functions as an essential regulatory node for EGF receptor- and Src-mediated cell growth

1 reference

12 December 2020

Epithelial-mesenchymal transition and its implications for the development of renal tubulointerstitial fibrosis.

1 reference

12 December 2020

Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells

1 reference

12 December 2020

Ceramide- and oxidant-induced insulin resistance involve loss of insulin-dependent Rac-activation and actin remodeling in muscle cells

1 reference

12 December 2020

The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance

1 reference

12 December 2020

Glucose-stimulated Cdc42 signaling is essential for the second phase of insulin secretion

1 reference

12 December 2020

Nephrin mediates actin reorganization via phosphoinositide 3-kinase in podocytes.

1 reference

12 December 2020

A dual role for IQGAP1 in regulating exocytosis

1 reference

12 December 2020

High-fat diet alters PP2A, TC10, and CIP4 expression in visceral adipose tissue of rats

1 reference

12 December 2020

Activation of the small GTPase Rac1 by a specific guanine-nucleotide-exchange factor suffices to induce glucose uptake into skeletal-muscle cells

1 reference

12 December 2020

Mammalian Rho GTPases: new insights into their functions from in vivo studies

1 reference

12 December 2020

Islet specific Wnt activation in human type II diabetes

1 reference

12 December 2020

Serine-71 phosphorylation of Rac1/Cdc42 diminishes the pathogenic effect of Clostridium difficile toxin A.

1 reference

12 December 2020

Drosophila Cip4/Toca-1 integrates membrane trafficking and actin dynamics through WASP and SCAR/WAVE.

1 reference

12 December 2020

Small G proteins in islet beta-cell function

1 reference

12 December 2020

Crucial role of the small GTPase Rac1 in insulin-stimulated translocation of glucose transporter 4 to the mouse skeletal muscle sarcolemma

1 reference

12 December 2020

SNARE conformational changes that prepare vesicles for exocytosis

1 reference

12 December 2020

Novel oncogenic mutations of CBL in human acute myeloid leukemia that activate growth and survival pathways depend on increased metabolism

1 reference

12 December 2020

Mechanisms of tubulointerstitial fibrosis

1 reference

12 December 2020

Diabetes: Podocytes lose their footing.

1 reference

12 December 2020

Signaling role of Cdc42 in regulating mammalian physiology

1 reference

12 December 2020

Diabetes mellitus and breast cancer outcomes: a systematic review and meta-analysis.

1 reference

12 December 2020

Rab27a, actin and beta-cell endocytosis

1 reference

12 December 2020

Physiology and pathology of endosome-to-Golgi retrograde sorting

1 reference

12 December 2020

Rab27a in pancreatic beta-cells, a busy protein in membrane trafficking

1 reference

12 December 2020

Cool-1/βPIX functions as a guanine nucleotide exchange factor in the cycling of Cdc42 to regulate insulin secretion

1 reference

12 December 2020

Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo

1 reference

12 December 2020

Phosphatidylinositol(4,5)bisphosphate coordinates actin-mediated mobilization and translocation of secretory vesicles to the plasma membrane of chromaffin cells.

1 reference

12 December 2020

Diabetes mellitus and the risk of cancer.

1 reference

12 December 2020

Cell biology and pathology of podocytes

1 reference

12 December 2020

The reno-protective effect of a phosphoinositide 3-kinase inhibitor wortmannin on streptozotocin-induced proteinuric renal disease rats

1 reference

12 December 2020

Tgf-β1 induces autophagy and promotes apoptosis in renal tubular epithelial cells

1 reference

12 December 2020

The small GTPase Cdc42 modulates the number of exocytosis-competent dense-core vesicles in PC12 cells.

1 reference

12 December 2020

Systematic review and meta-analysis of insulin therapy and risk of cancer.

1 reference

12 December 2020

Synapses of amphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretion through activation of p21-activated kinase (PAK1) in pancreatic β-Cells

1 reference

12 December 2020

Cdc42-interacting protein-4 promotes TGF-Β1-induced epithelial-mesenchymal transition and extracellular matrix deposition in renal proximal tubular epithelial cells

1 reference

12 December 2020

Regulation of insulin secretion in human pancreatic islets

1 reference

12 December 2020

The retromer complex - endosomal protein recycling and beyond

1 reference

12 December 2020

PAK signaling in cancer

1 reference

12 December 2020

Characterization and role of SCAI during renal fibrosis and epithelial-to-mesenchymal transition.

1 reference

12 December 2020

A p21-activated kinase (PAK1) signaling cascade coordinately regulates F-actin remodeling and insulin granule exocytosis in pancreatic β cells.

1 reference

12 December 2020

PRDM14 ensures naive pluripotency through dual regulation of signaling and epigenetic pathways in mouse embryonic stem cells

1 reference

12 December 2020

Mechanisms of insulin resistance in obesity

1 reference

12 December 2020

Beta cell dysfunction and insulin resistance

1 reference

12 December 2020

A molecular rheostat at the interface of cancer and diabetes

1 reference

12 December 2020

Actin dynamics regulated by the balance of neuronal Wiskott-Aldrich syndrome protein (N-WASP) and cofilin activities determines the biphasic response of glucose-induced insulin secretion

1 reference

12 December 2020

1 reference

12 December 2020

TGFβ and CCN2/CTGF mediate actin related gene expression by differential E2F1/CREB activation

1 reference

12 December 2020

Recent advances in obesity-induced inflammation and insulin resistance

1 reference

12 December 2020

Nm23-H1 regulates glucose-stimulated insulin secretion in pancreatic β-cells via Arf6-Rac1 signaling axis

1 reference

12 December 2020

Activated Cdc42-bound IQGAP1 determines the cellular endocytic site

1 reference

12 December 2020

Cdc42/N-WASP signaling links actin dynamics to pancreatic β cell delamination and differentiation

1 reference

12 December 2020

Cool-1-mediated inhibition of c-Cbl modulates multiple critical properties of glioblastomas, including the ability to generate tumors in vivo

1 reference

12 December 2020

PAK signalling during the development and progression of cancer

1 reference

12 December 2020

The current state of diabetes mellitus in India

1 reference

12 December 2020

MicroRNA in diabetic nephropathy: renin angiotensin, aGE/RAGE, and oxidative stress pathway.

1 reference

12 December 2020

YES, a Src family kinase, is a proximal glucose-specific activator of cell division cycle control protein 42 (Cdc42) in pancreatic islet β cells

1 reference

12 December 2020

Rho GTPases in insulin-stimulated glucose uptake

1 reference

12 December 2020

Chaihuang-Yishen granule inhibits diabetic kidney disease in rats through blocking TGF-β/Smad3 signaling.

1 reference

12 December 2020

P21 activated kinases: structure, regulation, and functions

1 reference

12 December 2020

P21-activated kinase in inflammatory and cardiovascular disease

1 reference

12 December 2020

Tracing PAKs from GI inflammation to cancer.

1 reference

12 December 2020

FFA-induced hepatic insulin resistance in vivo is mediated by PKCδ, NADPH oxidase, and oxidative stress

1 reference

12 December 2020

Advances in Preventive Therapy for Estrogen-Receptor-Negative Breast Cancer

1 reference

12 December 2020

Molecular mechanisms of diabetic kidney disease

1 reference

12 December 2020

Cdc42 controls the dilation of the exocytotic fusion pore by regulating membrane tension.

1 reference

12 December 2020

Podocyte injury caused by indoxyl sulfate, a uremic toxin and aryl-hydrocarbon receptor ligand

1 reference

12 December 2020

Mechanisms by which low glucose enhances the cytotoxicity of metformin to cancer cells both in vitro and in vivo

1 reference

12 December 2020

Vav family exchange factors: an integrated regulatory and functional view

1 reference

12 December 2020

Loss of PTEN promotes podocyte cytoskeletal rearrangement, aggravating diabetic nephropathy

1 reference

12 December 2020

Evidence for biological effects of metformin in operable breast cancer: biomarker analysis in a pre-operative window of opportunity randomized trial

1 reference

12 December 2020

A TOCA/CDC-42/PAR/WAVE functional module required for retrograde endocytic recycling

1 reference

12 December 2020

miR-30c Mediates Upregulation of Cdc42 and Pak1 in Diabetic Cardiomyopathy.

1 reference

12 December 2020

Spontaneous Cdc42 polarization independent of GDI-mediated extraction and actin-based trafficking

1 reference

12 December 2020

Rich1 negatively regulates the epithelial cell cycle, proliferation and adhesion by CDC42/RAC1-PAK1-Erk1/2 pathway.

1 reference

12 December 2020

Protective effects of calcitriol on diabetic nephropathy are mediated by down regulation of TGF-β1 and CIP4 in diabetic nephropathy rat.

1 reference

12 December 2020

GGPPS-mediated Rab27A geranylgeranylation regulates β cell dysfunction during type 2 diabetes development by affecting insulin granule docked pool formation.

1 reference

12 December 2020

Epithelial-to-Mesenchymal Transition in Diabetic Nephropathy: Fact or Fiction?

1 reference

12 December 2020

Insulin resistance: an additional risk factor in the pathogenesis of cardiovascular disease in type 2 diabetes

1 reference

12 December 2020

Metabolic reprogramming in cancer cells: glycolysis, glutaminolysis, and Bcl-2 proteins as novel therapeutic targets for cancer

1 reference

12 December 2020

p21-activated kinase 2 regulates HSPC cytoskeleton, migration, and homing via CDC42 activation and interaction with β-Pix

1 reference

12 December 2020

Cdc42 deficiency induces podocyte apoptosis by inhibiting the Nwasp/stress fibers/YAP pathway

1 reference

12 December 2020

NMDA receptors participate in the progression of diabetic kidney disease by decreasing Cdc42-GTP activation in podocytes

1 reference

12 December 2020

The p21-activated kinase (PAK1) is involved in diet-induced beta cell mass expansion and survival in mice and human islets

1 reference

12 December 2020

MYC-nick promotes cell migration by inducing fascin expression and Cdc42 activation

1 reference

12 December 2020

Transcriptomic and functional pathways analysis of ascorbate-induced cytotoxicity and resistance of Burkitt lymphoma

1 reference

12 December 2020

A causal role for hyperinsulinemia in obesity.

1 reference

12 December 2020

Characterization of the activation of small GTPases by their GEFs on membranes using artificial membrane tethering.

1 reference

12 December 2020

Model-based unsupervised learning informs metformin-induced cell-migration inhibition through an AMPK-independent mechanism in breast cancer

1 reference

12 December 2020

miR-29a regulated ER-positive breast cancer cell growth and invasion and is involved in the insulin signaling pathway

1 reference

12 December 2020

IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015 and 2040.

1 reference

12 December 2020

MicroRNA-29a functions as a potential tumor suppressor through directly targeting CDC42 in non-small cell lung cancer

1 reference

12 December 2020

Comment on American Diabetes Association. Standards of Medical Care in Diabetes-2017. Diabetes Care 2017;40(Suppl. 1):S1-S135

1 reference

12 December 2020

High glucose levels promote the proliferation of breast cancer cells through GTPases

1 reference

12 December 2020

Diabetic retinopathy: current understanding, mechanisms, and treatment strategies

1 reference

12 December 2020

Role of G-proteins in islet function in health and diabetes

1 reference

12 December 2020

Variations in MicroRNA-25 Expression Influence the Severity of Diabetic Kidney Disease.

1 reference

12 December 2020

Glucose insult elicits hyperactivation of cancer stem cells through miR-424-cdc42-prdm14 signalling axis

1 reference

12 December 2020

Glucocorticoids and beta-cell function.

1 reference

12 December 2020

Dissection of Glomerular Transcriptional Profile in Patients with Diabetic Nephropathy: SRGAP2a Protects Podocyte Structure and Function

1 reference

12 December 2020

Diabetes in China: Epidemiology and Genetic Risk Factors and Their Clinical Utility in Personalized Medication.

1 reference

12 December 2020

Circulating microRNA (miRNA) Expression Profiling in Plasma of Patients with Gestational Diabetes Mellitus Reveals Upregulation of miRNA miR-330-3p.

1 reference

12 December 2020

Interrelationship between diabetes mellitus and heart failure: the role of peroxisome proliferator-activated receptors in left ventricle performance.

1 reference

12 December 2020

Interleukin-4 (IL4) -590C/T (rs2243250) gene polymorphism is not associated with diabetic nephropathy (DN) in Caucasians with type 2 diabetes mellitus (T2DM)

1 reference

12 December 2020

miR-148b-3p inhibits gastric cancer metastasis by inhibiting the Dock6/Rac1/Cdc42 axis.

1 reference

12 December 2020

The cell biology of systemic insulin function.

1 reference

12 December 2020

Investigation of the therapy targets of Yi-Qi-Yang-Yin-Hua-Tan-Qu-Yu recipe on type 2 diabetes by serum proteome labeled with iTRAQ.

1 reference

12 December 2020

High glucose promotes tumor cell proliferation and migration in lung adenocarcinoma via the RAGE‑NOXs pathway.

1 reference

12 December 2020

Elevated levels of the small GTPase Cdc42 induces senescence in male rat mesenchymal stem cells.

1 reference

12 December 2020

Targeting Rac and Cdc42 GTPases in Cancer

1 reference

12 December 2020

Long isoform of VEGF stimulates cell migration of breast cancer by filopodia formation via NRP1/ARHGAP17/Cdc42 regulatory network

1 reference

12 December 2020

Machine Learning Helps Identify New Drug Mechanisms in Triple-Negative Breast Cancer

1 reference

12 December 2020

Cardiovascular protection in type 2 diabetes: Insights from recent outcome trials

1 reference

12 December 2020

The Impact of Serum Glucose, Anti-Diabetic Agents, and Statin Usage in Non-small Cell Lung Cancer Patients Treated With Definitive Chemoradiation.

1 reference

12 December 2020

Well-differentiated papillary mesothelioma of the peritoneum is genetically defined by mutually exclusive mutations in TRAF7 and CDC42.

1 reference

12 December 2020

Generation and Biological Characteristics of a Mouse Model of Breast Cancer that Co-presents with Diabetes Mellitus

1 reference

12 December 2020

Rational targeting Cdc42 restrains Th2 cell differentiation and prevents allergic airway inflammation

1 reference

12 December 2020

Protective effect of triterpenes against diabetes-induced β-cell damage: An overview of in vitro and in vivo studies

1 reference

12 December 2020

Causality between non-alcoholic fatty liver disease and risk of cardiovascular disease and type 2 diabetes: A meta-analysis with bias analysis

1 reference

12 December 2020

Type 2 diabetes as a predictor of survival among breast cancer patients: the multiethnic cohort

1 reference

12 December 2020

Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database

1 reference

12 December 2020

Hyperinsulinemia is associated with increasing insulin secretion but not with decreasing insulin clearance in an age-related metabolic dysfunction mice model

1 reference

12 December 2020

What magnetic resonance imaging reveals - A systematic review of the relationship between type II diabetes and associated brain distortions of structure and cognitive functioning

1 reference

12 December 2020

Association of the muscle/fat mass ratio with insulin resistance in gestational diabetes mellitus

1 reference

12 December 2020

The Relationship between Generalized and Abdominal Obesity with Diabetic Kidney Disease in Type 2 Diabetes: A Multiethnic Asian Study and Meta-Analysis

1 reference

12 December 2020

Type 2 diabetes and risk of colorectal cancer in two large U.S. prospective cohorts

1 reference

12 December 2020

Supplementation of Ameliorates Diabetic Nephropathy and Hepatic Steatosis by Activating Autophagy in Mice

1 reference

12 December 2020

Empagliflozin and kidney outcomes in Asian patients with type 2 diabetes and established cardiovascular disease: results from the EMPA-REG OUTCOME trial

1 reference

12 December 2020

Burden of cancer attributable to obesity, type 2 diabetes and associated risk factors

1 reference

12 December 2020

Progression of diabetic kidney disease and trajectory of kidney function decline in Chinese patients with Type 2 diabetes

1 reference

12 December 2020

High genetic risk scores of SLIT3, PLEKHA5 and PPP2R2C variants increased insulin resistance and interacted with coffee and caffeine consumption in middle-aged adults

1 reference

12 December 2020

Adipose Tissue Insulin Resistance in Youth on the Spectrum From Normal Weight to Obese and From Normal Glucose Tolerance to Impaired Glucose Tolerance to Type 2 Diabetes

1 reference

12 December 2020

Identifiers

DOI

10.3390/IJMS20010179

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30621321%20AND%20SRC:MED&resulttype=core&format=json

18 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30621321%20AND%20SRC:MED&resulttype=core&format=json

18 April 2020

PubMed publication ID

30621321

1 reference