(Q88954473)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29858187%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

title

Targeting Rac and Cdc42 GTPases in Cancer (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29858187%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

author name string

María Del Mar Maldonado

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29858187%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

Suranganie Dharmawardhane

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29858187%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

publication date

1 June 2018

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29858187%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29858187%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

volume

78

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29858187%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

issue

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29858187%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

page(s)

3101-3111

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29858187%20AND%20SRC:MED&resulttype=core&format=json

Rho GTPases and their effector proteins

29 March 2020

cites work

1 reference

12 December 2020

A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions

1 reference

12 December 2020

Trp(56) of rac1 specifies interaction with a subset of guanine nucleotide exchange factors

1 reference

12 December 2020

Activated Cdc42 Sequesters c-Cbl and Prevents EGF Receptor Degradation

1 reference

12 December 2020

Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

1 reference

12 December 2020

Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation

1 reference

12 December 2020

Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation

1 reference

12 December 2020

Azathioprine suppresses ezrin-radixin-moesin-dependent T cell-APC conjugation through inhibition of Vav guanosine exchange activity on Rac proteins

1 reference

12 December 2020

Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.

1 reference

12 December 2020

Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components

1 reference

12 December 2020

Expansion of normal and leukemic human hematopoietic stem/progenitor cells requires rac-mediated interaction with stromal cells

1 reference

12 December 2020

2-amino-N-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl} acetamide (OSU-03012), a celecoxib derivative, directly targets p21-activated kinase

1 reference

12 December 2020

Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases.

1 reference

12 December 2020

Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease

1 reference

12 December 2020

Targeting Large Kinase Active Site with Rigid, Bulky Octahedral Ruthenium Complexes

1 reference

12 December 2020

Luteolin, a flavonoid with potential for cancer prevention and therapy

1 reference

12 December 2020

Synthesis and biological evaluation of a 5-6-5 imidazole-phenyl-thiazole based alpha-helix mimetic

1 reference

12 December 2020

In vivo antitumor effect of a novel inhibitor of protein geranylgeranyltransferase-I

1 reference

12 December 2020

RhoA and Rac1 GTPases play major and differential roles in stromal cell-derived factor-1-induced cell adhesion and chemotaxis in multiple myeloma.

1 reference

12 December 2020

Rac1 contributes to trastuzumab resistance of breast cancer cells: Rac1 as a potential therapeutic target for the treatment of trastuzumab-resistant breast cancer

1 reference

12 December 2020

Virtual screening approach for the identification of new Rac1 inhibitors

1 reference

12 December 2020

A cell active chemical GEF inhibitor selectively targets the Trio/RhoG/Rac1 signaling pathway

1 reference

12 December 2020

Structure-activity relationship of isoform selective inhibitors of Rac1/1b GTPase nucleotide binding.

1 reference

12 December 2020

Identification of a small GTPase inhibitor using a high-throughput flow cytometry bead-based multiplex assay

1 reference

12 December 2020

Blockade of Rac1 activity induces G1 cell cycle arrest or apoptosis in breast cancer cells through downregulation of cyclin D1, survivin, and X-linked inhibitor of apoptosis protein

1 reference

12 December 2020

Inhibition of the Rho GTPase, Rac1, decreases estrogen receptor levels and is a novel therapeutic strategy in breast cancer

1 reference

12 December 2020

Novel inhibitors of Rac1 in metastatic breast cancer.

1 reference

12 December 2020

Androgen-induced cell migration: role of androgen receptor/filamin A association

1 reference

12 December 2020

Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size

1 reference

12 December 2020

Enhanced cytostatic activity of statins in mouse mammary carcinoma cells overexpressing β2-chimaerin

1 reference

12 December 2020

Cdc42 in oncogenic transformation, invasion, and tumorigenesis

1 reference

12 December 2020

Rac signaling in breast cancer: a tale of GEFs and GAPs.

1 reference

12 December 2020

Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase

1 reference

12 December 2020

The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis

1 reference

12 December 2020

RAC1 GTPase plays an important role in γ-irradiation induced G2/M checkpoint activation

1 reference

12 December 2020

Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2.

1 reference

12 December 2020

The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data

1 reference

12 December 2020

Targeting of Rac GTPases blocks the spread of intact human breast cancer.

1 reference

12 December 2020

Essential role of Cdc42 in Ras-induced transformation revealed by gene targeting

1 reference

12 December 2020

BART inhibits pancreatic cancer cell invasion by Rac1 inactivation through direct binding to active Rac1.

1 reference

12 December 2020

Inhibition of Rac controls NPM-ALK-dependent lymphoma development and dissemination

1 reference

12 December 2020

A novel small-molecule screening strategy identifies mitoxantrone as a RhoGTPase inhibitor.

1 reference

12 December 2020

Small molecule targeting Cdc42-intersectin interaction disrupts Golgi organization and suppresses cell motility

1 reference

12 December 2020

Characterization of a Cdc42 protein inhibitor and its use as a molecular probe

1 reference

12 December 2020

TCR-driven transendothelial migration of human effector memory CD4 T cells involves Vav, Rac, and myosin IIA

1 reference

12 December 2020

RAC1b overexpression in papillary thyroid carcinoma: a role to unravel

1 reference

12 December 2020

Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal

1 reference

12 December 2020

ACK1 tyrosine kinase: targeted inhibition to block cancer cell proliferation

1 reference

12 December 2020

Inhibition of redox/Fyn/c-Cbl pathway function by Cdc42 controls tumour initiation capacity and tamoxifen sensitivity in basal-like breast cancer cells

1 reference

12 December 2020

In vitro and in vivo effects of geranylgeranyltransferase I inhibitor P61A6 on non-small cell lung cancer cells

1 reference

12 December 2020

Rac1 signaling protects monocytic AML cells expressing the MLL-AF9 oncogene from caspase-mediated apoptotic death

1 reference

12 December 2020

Statins exert the pleiotropic effects through small GTP-binding protein dissociation stimulator upregulation with a resultant Rac1 degradation

1 reference

12 December 2020

Luteolin inhibits migration of human glioblastoma U-87 MG and T98G cells through downregulation of Cdc42 expression and PI3K/AKT activity

1 reference

12 December 2020

Combined inhibition of HER1/EGFR and RAC1 results in a synergistic antiproliferative effect on established and primary cultured human glioblastoma cells

1 reference

12 December 2020

Role of small GTPase protein Rac1 in cardiovascular diseases: development of new selective pharmacological inhibitors.

1 reference

12 December 2020

Targeting Cdc42 in cancer

1 reference

12 December 2020

FRAX597, a Small Molecule Inhibitor of the p21-activated Kinases, Inhibits Tumorigenesis of Neurofibromatosis Type 2 (NF2)-associated Schwannomas

1 reference

12 December 2020

Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease

1 reference

12 December 2020

A Rac1/Cdc42 GTPase-specific small molecule inhibitor suppresses growth of primary human prostate cancer xenografts and prolongs survival in mice

1 reference

12 December 2020

Preclinical development of novel Rac1-GEF signaling inhibitors using a rational design approach in highly aggressive breast cancer cell lines.

1 reference

12 December 2020

RAC1: an emerging therapeutic option for targeting cancer angiogenesis and metastasis

1 reference

12 December 2020

Pak and Rac GTPases promote oncogenic KIT-induced neoplasms

1 reference

12 December 2020

The somatic genomic landscape of glioblastoma

1 reference

12 December 2020

Small Rho GTPases in the control of cell shape and mobility

1 reference

12 December 2020

Targeting Cdc42 with the small molecule drug AZA197 suppresses primary colon cancer growth and prolongs survival in a preclinical mouse xenograft model by downregulation of PAK1 activity

1 reference

12 December 2020

Comprehensive molecular characterization of urothelial bladder carcinoma

1 reference

12 December 2020

2-Amino-3-(phenylsulfanyl)norbornane-2-carboxylate: an appealing scaffold for the design of Rac1-Tiam1 protein-protein interaction inhibitors

1 reference

12 December 2020

BNIP3 supports melanoma cell migration and vasculogenic mimicry by orchestrating the actin cytoskeleton

1 reference

12 December 2020

RAC1 inhibition as a therapeutic target for gefitinib-resistant non-small-cell lung cancer

1 reference

12 December 2020

Dock-family exchange factors in cell migration and disease

1 reference

12 December 2020

Development of EHop-016: a small molecule inhibitor of Rac.

1 reference

12 December 2020

p21-activated kinase inhibitors

1 reference

12 December 2020

Comprehensive molecular characterization of gastric adenocarcinoma

1 reference

12 December 2020

Comprehensive molecular profiling of lung adenocarcinoma

1 reference

12 December 2020

CDC42 inhibition suppresses progression of incipient intestinal tumors

1 reference

12 December 2020

Statins and breast cancer prognosis: evidence and opportunities.

1 reference

12 December 2020

Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to γ-irradiation

1 reference

12 December 2020

Proapoptotic and antiinvasive activity of Rac1 small molecule inhibitors on malignant glioma cells

1 reference

12 December 2020

miR-18a inhibits CDC42 and plays a tumour suppressor role in colorectal cancer cells

1 reference

12 December 2020

The Rac Inhibitor EHop-016 Inhibits Mammary Tumor Growth and Metastasis in a Nude Mouse Model

1 reference

12 December 2020

Selective efficacy of zoledronic acid on metastasis in a patient-derived orthotopic xenograph (PDOX) nude-mouse model of human pancreatic cancer

1 reference

12 December 2020

1 reference

12 December 2020

Pharmacokinetics of Rac inhibitor EHop-016 in mice by ultra-performance liquid chromatography tandem mass spectrometry

1 reference

12 December 2020

Statins are potential anticancerous agents (review).

1 reference

12 December 2020

Critical off-target effects of the widely used Rac1 inhibitors NSC23766 and EHT1864 in mouse platelets.

1 reference

12 December 2020

R-Ketorolac Targets Cdc42 and Rac1 and Alters Ovarian Cancer Cell Behaviors Critical for Invasion and Metastasis

1 reference

12 December 2020

Rho GTPases: Novel Players in the Regulation of the DNA Damage Response?

1 reference

12 December 2020

Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer

1 reference

12 December 2020

Direct Modulation of Small GTPase Activity and Function

1 reference

12 December 2020

Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases

1 reference

12 December 2020

Transmigration characteristics of breast cancer and melanoma cells through the brain endothelium: Role of Rac and PI3K.

1 reference

12 December 2020

Genomic analyses identify molecular subtypes of pancreatic cancer

1 reference

12 December 2020

Cdc42 deficiency induces podocyte apoptosis by inhibiting the Nwasp/stress fibers/YAP pathway

1 reference

12 December 2020

Deregulation of Rho GTPases in cancer

1 reference

12 December 2020

Effective molecular targeting of CDK4/6 and IGF-1R in a rare FUS-ERG fusion CDKN2A-deletion doxorubicin-resistant Ewing's sarcoma patient-derived orthotopic xenograft (PDOX) nude-mouse model.

1 reference

12 December 2020

Regulating Rho GTPases and their regulators

1 reference

12 December 2020

Integrin-α10 Dependency Identifies RAC and RICTOR as Therapeutic Targets in High-Grade Myxofibrosarcoma.

1 reference

12 December 2020

Vemurafenib-resistant BRAF-V600E-mutated melanoma is regressed by MEK-targeting drug trametinib, but not cobimetinib in a patient-derived orthotopic xenograft (PDOX) mouse model

1 reference

12 December 2020

The current evidence on statin use and prostate cancer prevention: are we there yet?

1 reference

12 December 2020

RAC1 GTP-ase signals Wnt-beta-catenin pathway mediated integrin-directed metastasis-associated tumor cell phenotypes in triple negative breast cancers

1 reference

12 December 2020

Pharmacological inhibition of Rac1-PAK1 axis restores tamoxifen sensitivity in human resistant breast cancer cells.

1 reference

12 December 2020

Novel DOCK2-selective inhibitory peptide that suppresses B-cell line migration

1 reference

12 December 2020

PI3K signaling in cancer: beyond AKT.

1 reference

12 December 2020

Discovery and characterization of small molecule Rac1 inhibitors

1 reference

12 December 2020

Therapeutic sensitivity to Rac GTPase inhibition requires consequential suppression of mTORC1, AKT, and MEK signaling in breast cancer

1 reference

12 December 2020

Combination of gemcitabine and docetaxel regresses both gastric leiomyosarcoma proliferation and invasion in an imageable patient-derived orthotopic xenograft (iPDOX) model.

1 reference

12 December 2020

Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer.

1 reference

12 December 2020

Targeting Ras-Driven Cancer Cell Survival and Invasion through Selective Inhibition of DOCK1.

1 reference

12 December 2020

Synthetic 8-hydroxydeoxyguanosine inhibited metastasis of pancreatic cancer through concerted inhibitions of ERM and Rho-GTPase.

1 reference

12 December 2020

Commentary on "Integrative clinical genomics of advanced prostate cancer". Robinson D, Van Allen EM, Wu YM, Schultz N, Lonigro RJ, Mosquera JM, Montgomery B, Taplin ME, Pritchard CC, Attard G, Beltran H, Abida W, Bradley RK, Vinson J, Cao X, Vats P,

1 reference

12 December 2020

The Rac GTPase in Cancer: From Old Concepts to New Paradigms

1 reference

12 December 2020

Rho GTPases as therapeutic targets in cancer (Review).

1 reference

12 December 2020

The R-enantiomer of ketorolac delays mammary tumor development in mouse mammary tumor virus-polyoma middle T antigen (MMTV-PyMT) mice.

1 reference

12 December 2020

Pharmacological Rac1 inhibitors with selective apoptotic activity in human acute leukemic cell lines

1 reference

12 December 2020

10.1158/0008-5472.CAN-18-0619

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29858187%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29858187%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

PubMed publication ID

29858187

1 reference