(Q55068394)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25628054%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

title

Critical off-target effects of the widely used Rac1 inhibitors NSC23766 and EHT1864 in mouse platelets (English)

1 reference

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N6-[2-[5-(diethylamino)pentan-2-ylamino]-6-methyl-4-pyrimidinyl]-2-methylquinoline-4,6-diamine

28 February 2020

main subject

1 reference

Julius Frederik Heidenreich

ChEBI release 2020-05-28

ChEBI ID

144984

author

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25628054%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Cord Brakebusch

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25628054%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

author name string

S Dütting

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25628054%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

D Cherpokova

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25628054%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

E Amin

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25628054%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

S-C Zhang

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25628054%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

M R Ahmadian

6

1 reference

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28 February 2020

B Nieswandt

8

1 reference

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28 February 2020

publication date

23 February 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25628054%20AND%20SRC:MED&resulttype=core&format=json

Journal of Thrombosis and Haemostasis

28 February 2020

published in

1 reference

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28 February 2020

volume

13

1 reference

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28 February 2020

issue

5

1 reference

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28 February 2020

page(s)

827-838

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25628054%20AND%20SRC:MED&resulttype=core&format=json

Arterial thrombosis--insidious, unpredictable and deadly

28 February 2020

cites work

1 reference

Platelet adhesion and activation mechanisms in arterial thrombosis and ischaemic stroke

21 January 2018

1 reference

Platelets in atherothrombosis: lessons from mouse models

21 January 2018

1 reference

Rho GTPases in cell biology

21 January 2018

1 reference

Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow.

21 January 2018

1 reference

Defective tubulin organization and proplatelet formation in murine megakaryocytes lacking Rac1 and Cdc42.

21 January 2018

1 reference

Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets.

21 January 2018

1 reference

Rac1 is essential for phospholipase C-gamma2 activation in platelets

21 January 2018

1 reference

Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis.

21 January 2018

1 reference

Genetic and pharmacologic evidence that Rac1 GTPase is involved in regulation of platelet secretion and aggregation.

21 January 2018

1 reference

The Rac and Rho hall of fame: a decade of hypertrophic signaling hits

21 January 2018

1 reference

Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

21 January 2018

1 reference

Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases.

21 January 2018

1 reference

Unraveling a novel Rac1-mediated signaling pathway that regulates cofilin dephosphorylation and secretion in thrombin-stimulated platelets

21 January 2018

1 reference

The small GTPase Rac1 is required for smooth muscle contraction

21 January 2018

1 reference

NSC23766, a widely used inhibitor of Rac1 activation, additionally acts as a competitive antagonist at muscarinic acetylcholine receptors

21 January 2018

1 reference

Rac1 is crucial for hair follicle integrity but is not essential for maintenance of the epidermis

21 January 2018

1 reference

Anti-glycoprotein VI treatment severely compromises hemostasis in mice with reduced alpha2beta1 levels or concomitant aspirin therapy

21 January 2018

1 reference

Biochemical assays to characterize Rho GTPases

21 January 2018

1 reference

Liposome reconstitution and modulation of recombinant prenylated human Rac1 by GEFs, GDI1 and Pak1.

21 January 2018

1 reference

The centrosomal adaptor TACC3 and the microtubule polymerase chTOG interact via defined C-terminal subdomains in an Aurora-A kinase-independent manner.

21 January 2018

1 reference

Comparative gel-based phosphoproteomics in response to signaling molecules.

21 January 2018

1 reference

Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist

21 January 2018

1 reference

Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase

21 January 2018

1 reference

The final steps of integrin activation: the end game

21 January 2018

1 reference

S6K1 and mTOR regulate Rac1-driven platelet activation and aggregation.

21 January 2018

1 reference

Rap1-Rac1 circuits potentiate platelet activation

21 January 2018

1 reference

Two distinct roles of mitogen-activated protein kinases in platelets and a novel Rac1-MAPK-dependent integrin outside-in retractile signaling pathway

21 January 2018

1 reference

The von Willebrand factor-glycoprotein Ib/V/IX interaction induces actin polymerization and cytoskeletal reorganization in rolling platelets and glycoprotein Ib/V/IX-transfected cells.

21 January 2018

1 reference

The role of Rac1 in glycoprotein Ib-IX-mediated signal transduction and integrin activation

21 January 2018

1 reference

Mammalian Rho GTPases: new insights into their functions from in vivo studies

21 January 2018

1 reference

Rac guanosine triphosphatases represent a potential target in AML

21 January 2018

1 reference

Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease

21 January 2018

1 reference

Maladaptive dendritic spine remodeling contributes to diabetic neuropathic pain.

21 January 2018

1 reference

Inhibition of Rac1 decreases the severity of pancreatitis and pancreatitis-associated lung injury in mice

21 January 2018

1 reference

Inhibition of Rac controls NPM-ALK-dependent lymphoma development and dissemination

21 January 2018

1 reference

p21-activated kinases in cancer

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/JTH.12861

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25628054%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

1 reference