(Q46428451)

22 December 2017

title

Rac1 is essential for phospholipase C-gamma2 activation in platelets (English)

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22 December 2017

Cord Brakebusch

8

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author name string

Irina Pleines

1

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22 December 2017

Margitta Elvers

2

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22 December 2017

Amrei Strehl

3

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22 December 2017

Miroslava Pozgajova

4

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22 December 2017

David Varga-Szabo

5

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22 December 2017

Frauke May

6

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22 December 2017

Anna Chrostek-Grashoff

7

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22 December 2017

Bernhard Nieswandt

9

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22 December 2017

publication date

13 August 2008

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22 December 2017

published in

Pfluegers Archiv

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22 December 2017

volume

457

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22 December 2017

issue

5

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22 December 2017

page(s)

1173-1185

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22 December 2017

https://scigraph.springernature.com/pub.10.1007/s00424-008-0573-7

exact match

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cites work

Activation of the small GTPases, rac and cdc42, after ligation of the platelet PAR-1 receptor

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12 December 2020

Rac1 is required for the formation of three germ layers during gastrulation.

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12 December 2020

Importance of platelet phospholipase Cgamma2 signaling in arterial thrombosis as a function of lesion severity

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12 December 2020

Platelets in atherothrombosis

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Specificity and structural requirements of phospholipase C-beta stimulation by Rho GTPases versus G protein beta gamma dimers

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12 December 2020

Identification of a novel integrin signaling pathway involving the kinase Syk and the guanine nucleotide exchange factor Vav1

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12 December 2020

Relative antithrombotic effect of soluble GPVI dimer compared with anti-GPVI antibodies in mice

1 reference

12 December 2020

Collagen-platelet interaction: Gly-Pro-Hyp is uniquely specific for platelet Gp VI and mediates platelet activation by collagen

1 reference

12 December 2020

Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets

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12 December 2020

Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen

1 reference

12 December 2020

Identification of critical antigen-specific mechanisms in the development of immune thrombocytopenic purpura in mice.

1 reference

12 December 2020

Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells.

1 reference

12 December 2020

The C-type lectin receptors CLEC-2 and Dectin-1, but not DC-SIGN, signal via a novel YXXL-dependent signaling cascade

1 reference

12 December 2020

Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow.

1 reference

12 December 2020

Leukotriene D4 induces association of active RhoA with phospholipase C-gamma1 in intestinal epithelial cells

1 reference

12 December 2020

Rac, a small guanosine triphosphate-binding protein, and p21-activated kinase are activated during platelet spreading on collagen-coated surfaces: roles of integrin alpha(2)beta(1).

1 reference

12 December 2020

Mechanisms of phospholipase C-regulated calcium entry

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12 December 2020

Collagen but not fibrinogen surfaces induce bleb formation, exposure of phosphatidylserine, and procoagulant activity of adherent platelets: evidence for regulation by protein tyrosine kinase-dependent Ca2+ responses

1 reference

12 December 2020

Platelet-collagen interaction: is GPVI the central receptor?

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12 December 2020

Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in mice

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12 December 2020

Calcium signalling: dynamics, homeostasis and remodelling

1 reference

12 December 2020

Genetic and pharmacologic evidence that Rac1 GTPase is involved in regulation of platelet secretion and aggregation.

1 reference

12 December 2020

The P2Y(12) receptor induces platelet aggregation through weak activation of the alpha(IIb)beta(3) integrin--a phosphoinositide 3-kinase-dependent mechanism

1 reference

12 December 2020

Differential regulation of Rho and Rac through heterotrimeric G-proteins and cyclic nucleotides.

1 reference

12 December 2020

Stimulation of phospholipase C-beta2 by the Rho GTPases Cdc42Hs and Rac1.

1 reference

12 December 2020

A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivo

1 reference

12 December 2020

The role of ITAM- and ITIM-coupled receptors in platelet activation by collagen

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12 December 2020

Cell adhesion mechanisms in platelets

1 reference

12 December 2020

Costimulation of Gi- and G12/G13-mediated signaling pathways induces integrin alpha IIbbeta 3 activation in platelets

1 reference

12 December 2020

A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2.

1 reference

12 December 2020

Unresponsiveness of platelets lacking both Galpha(q) and Galpha(13). Implications for collagen-induced platelet activation

1 reference

12 December 2020

Rac2 regulation of phospholipase C-beta 2 activity and mode of membrane interactions in intact cells

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12 December 2020

Reduced thrombus stability in mice lacking the alpha2A-adrenergic receptor

1 reference

12 December 2020

Characterisation of Rac activation in thrombin- and collagen-stimulated human blood platelets

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12 December 2020

Flow cytometric detection of activated mouse integrin alphaIIbbeta3 with a novel monoclonal antibody

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12 December 2020

Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets

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12 December 2020

Interaction of elongation factor-1alpha and pleckstrin homology domain of phospholipase C-gamma 1 with activating its activity

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12 December 2020

Isozyme-specific stimulation of phospholipase C-gamma2 by Rac GTPases

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12 December 2020

Inducible gene targeting in mice

1 reference

12 December 2020

Anti-glycoprotein VI treatment severely compromises hemostasis in mice with reduced alpha2beta1 levels or concomitant aspirin therapy

1 reference

12 December 2020

Structure-function based design of small molecule inhibitors targeting Rho family GTPases

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12 December 2020

The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction

1 reference

12 December 2020

Rat platelets are deficient in internal Ca2+ release and require influx of extracellular Ca2+ for activation

1 reference

12 December 2020

Rac1 is crucial for hair follicle integrity but is not essential for maintenance of the epidermis

1 reference

12 December 2020

Loss of talin1 in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo

1 reference

12 December 2020

Defective platelet activation in G alpha(q)-deficient mice.

1 reference

12 December 2020

Activation of platelet function through G protein-coupled receptors

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12 December 2020

10.1007/S00424-008-0573-7

Identifiers

DOI

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22 December 2017

PubMed ID

18704487

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22 December 2017