(Q51031095)

26 May 2018

title

Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer. (English)

1 reference

26 May 2018

author

Yamil Gerena

6

1 reference

PubMed publication ID

28450422

27 March 2018

http://europepmc.org/abstract/MED/28450422

Manuel Buitrago Blanco

7

object named as

Manuel Blanco

1 reference

PMC publication ID

5418092

Suranganie Dharmawardhane

26 May 2018

12

object named as

Suranganie Dharmawardhane

1 reference

26 May 2018

author name string

Tessa Humphries-Bickley

1

1 reference

26 May 2018

Linette Castillo-Pichardo

2

1 reference

26 May 2018

Eliud Hernandez-O'Farrill

3

1 reference

26 May 2018

Luis D Borrero-Garcia

4

1 reference

26 May 2018

Ingrid Forestier-Roman

5

1 reference

26 May 2018

Michael J Rivera-Robles

8

1 reference

26 May 2018

José R Rodriguez-Medina

9

1 reference

26 May 2018

Luis A Cubano

10

1 reference

26 May 2018

Cornelis P Vlaar

11

1 reference

26 May 2018

publication date

1 May 2017

1 reference

26 May 2018

Molecular Cancer Therapeutics

published in

1 reference

26 May 2018

volume

16

1 reference

26 May 2018

issue

5

1 reference

26 May 2018

page(s)

805-818

1 reference

26 May 2018

Anti-Breast Cancer Potential of Quercetin via the Akt/AMPK/Mammalian Target of Rapamycin (mTOR) Signaling Cascade

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Role of EMT in Metastasis and Therapy Resistance

26 May 2018

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Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases

26 May 2018

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Modeling of Cancer Stem Cell State Transitions Predicts Therapeutic Response

26 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418092

Rho GTPase signalling in cell migration

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418092

Tumor imaging technologies in mouse models

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418092

Pharmacokinetics of Rac inhibitor EHop-016 in mice by ultra-performance liquid chromatography tandem mass spectrometry

26 May 2018

1 reference

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Equol, an isoflavone metabolite, regulates cancer cell viability and protein synthesis initiation via c-Myc and eIF4G.

26 May 2018

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The Rac Inhibitor EHop-016 Inhibits Mammary Tumor Growth and Metastasis in a Nude Mouse Model

26 May 2018

1 reference

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Development of EHop-016: a small molecule inhibitor of Rac.

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418092

Rho GTPases as regulators of mitosis and cytokinesis in mammalian cells

26 May 2018

1 reference

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STAT3 Target Genes Relevant to Human Cancers

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418092

P21 activated kinases: structure, regulation, and functions

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418092

BNIP3 supports melanoma cell migration and vasculogenic mimicry by orchestrating the actin cytoskeleton

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418092

Pak and Rac GTPases promote oncogenic KIT-induced neoplasms

26 May 2018

1 reference

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A Rac1/Cdc42 GTPase-specific small molecule inhibitor suppresses growth of primary human prostate cancer xenografts and prolongs survival in mice

26 May 2018

1 reference

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TCR-driven transendothelial migration of human effector memory CD4 T cells involves Vav, Rac, and myosin IIA

26 May 2018

1 reference

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26 May 2018

PAK signaling in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418092

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418092

p21-Activated kinase inhibitors: a patent review

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418092

Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418092

Anoikis: an emerging hallmark in health and diseases

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418092

Rac signaling in breast cancer: a tale of GEFs and GAPs.

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418092

The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418092

Cdc42 in oncogenic transformation, invasion, and tumorigenesis

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418092

Novel inhibitors of Rac1 in metastatic breast cancer.

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418092

Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418092

Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418092

Rac1 contributes to trastuzumab resistance of breast cancer cells: Rac1 as a potential therapeutic target for the treatment of trastuzumab-resistant breast cancer

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418092

P21-activated kinase is required for mitotic progression and regulates Plk1.

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418092

Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases.

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418092

Kinetics of metastatic breast cancer cell trafficking in bone.

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418092

Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418092

Rac-WAVE2 signaling is involved in the invasive and metastatic phenotypes of murine melanoma cells.

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418092

Exploration of essential gene functions via titratable promoter alleles

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418092

Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418092

Cell polarity: Par6, aPKC and cytoskeletal crosstalk

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418092

The role of Rho GTPases in disease development

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418092

Rac1 mediates STAT3 activation by autocrine IL-6

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418092

Rac1 protects epithelial cells against anoikis

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418092

The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418092

Regulation of STAT3 by direct binding to the Rac1 GTPase

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418092

Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418092

Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418092

The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418092

26 May 2018

Integrins and anoikis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418092

Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418092

An essential role for Rac in Ras transformation

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5418092

26 May 2018

Focal adhesion assembly

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28450422

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/1535-7163.MCT-16-0442

1 reference

26 May 2018

PMC publication ID

5418092

1 reference

26 May 2018

PubMed publication ID

28450422

1 reference

26 May 2018