(Q61775759)

English

The human carcinogen aristolochic acid i is activated to form DNA adducts by human NAD(P)H:quinone oxidoreductase without the contribution of acetyltransferases or sulfotransferases

scientific article published on 02 March 2011

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24 January 2020

The human carcinogen aristolochic acid i is activated to form DNA adducts by human NAD(P)H:quinone oxidoreductase without the contribution of acetyltransferases or sulfotransferases (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21370283%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Marie Stiborová

1

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24 January 2020

4

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24 January 2020

Václav Martínek

5

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24 January 2020

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Eva Frei

3

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24 January 2020

Jaroslav Mareš

2

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24 January 2020

Heinz H Schmeiser

6

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24 January 2020

publication date

2 March 2011

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24 January 2020

Environmental and Molecular Mutagenesis

1 reference

Europe PubMed Central

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24 January 2020

52

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24 January 2020

6

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24 January 2020

448-459

1 reference

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PubMed publication ID

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24 January 2020

Two-electron reduction of quinones by rat liver NAD(P)H:quinone oxidoreductase: quantitative structure-activity relationships.

1 reference

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7 January 2021

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3-Nitrobenzanthrone, a potential human cancer hazard in diesel exhaust and urban air pollution: a review of the evidence.

1 reference

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7 January 2021

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Sequence-specific detection of aristolochic acid-DNA adducts in the human p53 gene by terminal transferase-dependent PCR.

1 reference

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7 January 2021

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Is aristolochic acid a risk factor for Balkan endemic nephropathy-associated urothelial cancer?

1 reference

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7 January 2021

based on heuristic

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Aristolochic acid as a probable human cancer hazard in herbal remedies: a review.

1 reference

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7 January 2021

based on heuristic

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Aristolochic acid (AA)-DNA adduct as marker of AA exposure and risk factor for AA nephropathy-associated cancer

1 reference

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7 January 2021

based on heuristic

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Environmental pollutant and potent mutagen 3-nitrobenzanthrone forms DNA adducts after reduction by NAD(P)H:quinone oxidoreductase and conjugation by acetyltransferases and sulfotransferases in human hepatic cytosols

1 reference

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7 January 2021

based on heuristic

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Aristolochic acid mutagenesis: molecular clues to the aetiology of Balkan endemic nephropathy-associated urothelial cancer.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Gene expression changes induced by the human carcinogen aristolochic acid I in renal and hepatic tissue of mice

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Genetic polymorphisms of cytochrome P450 among patients with Balkan endemic nephropathy (BEN)

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

32P-post-labelling analysis of DNA adducts formed by aristolochic acid in tissues from patients with Chinese herbs nephropathy

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanism of NAD(P)H:Quinone reductase: Ab initio studies of reduced flavin

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Investigation of the metabolism and reductive activation of carcinogenic aristolochic acids in rats.

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

6 Statistical analysis of enzyme kinetic data

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Chinese herbs nephropathy: a clue to Balkan endemic nephropathy?

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Urothelial lesions in Chinese-herb nephropathy.

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Aristolochic acid nephropathy: a worldwide problem

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Structures of recombinant human and mouse NAD(P)H:quinone oxidoreductases: species comparison and structural changes with substrate binding and release

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure-Based Development of Anticancer Drugs

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Further studies with a cell immortalization assay to investigate the mutation signature of aristolochic acid in human p53 sequences

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

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Hydride Transfer from 9-Substituted 10-Methyl-9,10-dihydroacridines to Hydride Acceptors via Charge-Transfer Complexes and Sequential Electron−Proton−Electron Transfer. A Negative Temperature Dependence of the Rates

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Sulfotransferases in the bioactivation of xenobiotics

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Aristolochic acid and the etiology of endemic (Balkan) nephropathy

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

A review of human carcinogens—Part A: pharmaceuticals

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular genetics and function of NAT1 and NAT2: role in aromatic amine metabolism and carcinogenesis

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

A semiempirical free energy force field with charge-based desolvation

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The role of specific reductases in the intracellular activation and binding of 2-nitroimidazoles

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

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Linking environmental carcinogen exposure to TP53 mutations in human tumours using the human TP53 knock-in (Hupki) mouse model.

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Population-based case-control study of Chinese herbal products containing aristolochic acid and urinary tract cancer risk

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Late onset of bladder urothelial carcinoma after kidney transplantation for end-stage aristolochic acid nephropathy: a case series with 15-year follow-up

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

The three-dimensional structure of NAD(P)H:quinone reductase, a flavoprotein involved in cancer chemoprotection and chemotherapy: mechanism of the two-electron reduction

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Human tumor p53 mutations are selected for in mouse embryonic fibroblasts harboring a humanized p53 gene

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Detection of Herba Aristolochia Mollissemae in a patient with unexplained nephropathy

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

NRH:quinone oxidoreductase2 (NQO2).

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Urothelial malignant disease and Chinese herbal nephropathy

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

DNA adducts and p53 mutations in a patient with aristolochic acid-associated nephropathy

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Progression rate of Chinese herb nephropathy: impact of Aristolochia fangchi ingested dose

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Human sulphotransferases are involved in the activation of aristolochic acids and are expressed in renal target tissue

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

TP53 mutation signature supports involvement of aristolochic acid in the aetiology of endemic nephropathy-associated tumours

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi)

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

32P-postlabelling analysis of the DNA adducts formed by aristolochic acid I and II.

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

The 32P-postlabeling assay for DNA adducts

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

DT-diaphorase and cancer chemotherapy

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

DNA adduct formation of aristolochic acid I and II in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Comparison of DNA adduct formation by aristolochic acids in various in vitro activation systems by 32P-post-labelling: evidence for reductive activation by peroxidases

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Increased frequency of a null-allele for NAD(P)H: quinone oxidoreductase in patients with urological malignancies

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of DNA adducts formed by aristolochic acids in the target organ (forestomach) of rats by 32P-postlabelling analysis using different chromatographic procedures

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Evidence for reductive activation of carcinogenic aristolochic acids by prostaglandin H synthase -- (32)P-postlabeling analysis of DNA adduct formation

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Human enzymes involved in the metabolic activation of carcinogenic aristolochic acids: evidence for reductive activation by cytochromes P450 1A1 and 1A2

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Isolation of DT-Diaphorase [NAD(P)H Dehydrogenase (Quinone)] from Rat Liver Cytosol: Identification of New Enzyme Substrates, Carcinogenic Aristolochic Acids

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Carcinogenic aristolochic acids upon activation by DT-diaphorase form adducts found in DNA of patients with Chinese herbs nephropathy.

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Human cytosolic enzymes involved in the metabolic activation of carcinogenic aristolochic acid: evidence for reductive activation by human NAD(P)H:quinone oxidoreductase.

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Human hepatic and renal microsomes, cytochromes P450 1A1/2, NADPH:cytochrome P450 reductase and prostaglandin H synthase mediate the formation of aristolochic acid-DNA adducts found in patients with urothelial cancer.

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

The binding of aristolochic acid I to the active site of human cytochromes P450 1A1 and 1A2 explains their potential to reductively activate this human carcinogen

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Metabolic activation of carcinogenic aristolochic acid, a risk factor for Balkan endemic nephropathy.

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Biotransformation enzymes in development of renal injury and urothelial cancer caused by aristolochic acid

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanisms of the different DNA adduct forming potentials of the urban air pollutants 2-nitrobenzanthrone and carcinogenic 3-nitrobenzanthrone

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Misuse of herbal remedies: the case of an outbreak of terminal renal failure in Belgium (Chinese herbs nephropathy)

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Rapidly progressive interstitial renal fibrosis in young women: association with slimming regimen including Chinese herbs

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Kinetic and docking studies of the interaction of quinones with the quinone reductase active site

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1002/EM.20642

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21370283%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21370283%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

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