(Q61775759)

English

The human carcinogen aristolochic acid i is activated to form DNA adducts by human NAD(P)H:quinone oxidoreductase without the contribution of acetyltransferases or sulfotransferases

scientific article published on 02 March 2011

In more languages

default values for all languages

No label defined

No description defined

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21370283%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

The human carcinogen aristolochic acid i is activated to form DNA adducts by human NAD(P)H:quinone oxidoreductase without the contribution of acetyltransferases or sulfotransferases (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21370283%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Marie Stiborová

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21370283%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21370283%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Václav Martínek

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21370283%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

author name string

Eva Frei

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21370283%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Jaroslav Mareš

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21370283%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Heinz H Schmeiser

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21370283%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

publication date

2 March 2011

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21370283%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Environmental and Molecular Mutagenesis

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21370283%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

52

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21370283%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21370283%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

448-459

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21370283%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Two-electron reduction of quinones by rat liver NAD(P)H:quinone oxidoreductase: quantitative structure-activity relationships.

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

3-Nitrobenzanthrone, a potential human cancer hazard in diesel exhaust and urban air pollution: a review of the evidence.

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Sequence-specific detection of aristolochic acid-DNA adducts in the human p53 gene by terminal transferase-dependent PCR.

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Is aristolochic acid a risk factor for Balkan endemic nephropathy-associated urothelial cancer?

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Aristolochic acid as a probable human cancer hazard in herbal remedies: a review.

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Aristolochic acid (AA)-DNA adduct as marker of AA exposure and risk factor for AA nephropathy-associated cancer

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Environmental pollutant and potent mutagen 3-nitrobenzanthrone forms DNA adducts after reduction by NAD(P)H:quinone oxidoreductase and conjugation by acetyltransferases and sulfotransferases in human hepatic cytosols

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Aristolochic acid mutagenesis: molecular clues to the aetiology of Balkan endemic nephropathy-associated urothelial cancer.

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Gene expression changes induced by the human carcinogen aristolochic acid I in renal and hepatic tissue of mice

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Genetic polymorphisms of cytochrome P450 among patients with Balkan endemic nephropathy (BEN)

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

32P-post-labelling analysis of DNA adducts formed by aristolochic acid in tissues from patients with Chinese herbs nephropathy

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanism of NAD(P)H:Quinone reductase: Ab initio studies of reduced flavin

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Investigation of the metabolism and reductive activation of carcinogenic aristolochic acids in rats.

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

6 Statistical analysis of enzyme kinetic data

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Chinese herbs nephropathy: a clue to Balkan endemic nephropathy?

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Urothelial lesions in Chinese-herb nephropathy.

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Aristolochic acid nephropathy: a worldwide problem

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Structures of recombinant human and mouse NAD(P)H:quinone oxidoreductases: species comparison and structural changes with substrate binding and release

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure-Based Development of Anticancer Drugs

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Further studies with a cell immortalization assay to investigate the mutation signature of aristolochic acid in human p53 sequences

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Hydride Transfer from 9-Substituted 10-Methyl-9,10-dihydroacridines to Hydride Acceptors via Charge-Transfer Complexes and Sequential Electron−Proton−Electron Transfer. A Negative Temperature Dependence of the Rates

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Sulfotransferases in the bioactivation of xenobiotics

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Aristolochic acid and the etiology of endemic (Balkan) nephropathy

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

A review of human carcinogens—Part A: pharmaceuticals

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular genetics and function of NAT1 and NAT2: role in aromatic amine metabolism and carcinogenesis

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

A semiempirical free energy force field with charge-based desolvation

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

The role of specific reductases in the intracellular activation and binding of 2-nitroimidazoles

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Linking environmental carcinogen exposure to TP53 mutations in human tumours using the human TP53 knock-in (Hupki) mouse model.

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Population-based case-control study of Chinese herbal products containing aristolochic acid and urinary tract cancer risk

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Late onset of bladder urothelial carcinoma after kidney transplantation for end-stage aristolochic acid nephropathy: a case series with 15-year follow-up

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

The three-dimensional structure of NAD(P)H:quinone reductase, a flavoprotein involved in cancer chemoprotection and chemotherapy: mechanism of the two-electron reduction

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Human tumor p53 mutations are selected for in mouse embryonic fibroblasts harboring a humanized p53 gene

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Detection of Herba Aristolochia Mollissemae in a patient with unexplained nephropathy

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

NRH:quinone oxidoreductase2 (NQO2).

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Urothelial malignant disease and Chinese herbal nephropathy

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

DNA adducts and p53 mutations in a patient with aristolochic acid-associated nephropathy

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Progression rate of Chinese herb nephropathy: impact of Aristolochia fangchi ingested dose

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Human sulphotransferases are involved in the activation of aristolochic acids and are expressed in renal target tissue

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

TP53 mutation signature supports involvement of aristolochic acid in the aetiology of endemic nephropathy-associated tumours

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi)

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

32P-postlabelling analysis of the DNA adducts formed by aristolochic acid I and II.

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

The 32P-postlabeling assay for DNA adducts

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

DT-diaphorase and cancer chemotherapy

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

DNA adduct formation of aristolochic acid I and II in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Comparison of DNA adduct formation by aristolochic acids in various in vitro activation systems by 32P-post-labelling: evidence for reductive activation by peroxidases

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Increased frequency of a null-allele for NAD(P)H: quinone oxidoreductase in patients with urological malignancies

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of DNA adducts formed by aristolochic acids in the target organ (forestomach) of rats by 32P-postlabelling analysis using different chromatographic procedures

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Evidence for reductive activation of carcinogenic aristolochic acids by prostaglandin H synthase -- (32)P-postlabeling analysis of DNA adduct formation

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Human enzymes involved in the metabolic activation of carcinogenic aristolochic acids: evidence for reductive activation by cytochromes P450 1A1 and 1A2

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Isolation of DT-Diaphorase [NAD(P)H Dehydrogenase (Quinone)] from Rat Liver Cytosol: Identification of New Enzyme Substrates, Carcinogenic Aristolochic Acids

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Carcinogenic aristolochic acids upon activation by DT-diaphorase form adducts found in DNA of patients with Chinese herbs nephropathy.

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Human cytosolic enzymes involved in the metabolic activation of carcinogenic aristolochic acid: evidence for reductive activation by human NAD(P)H:quinone oxidoreductase.

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Human hepatic and renal microsomes, cytochromes P450 1A1/2, NADPH:cytochrome P450 reductase and prostaglandin H synthase mediate the formation of aristolochic acid-DNA adducts found in patients with urothelial cancer.

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

The binding of aristolochic acid I to the active site of human cytochromes P450 1A1 and 1A2 explains their potential to reductively activate this human carcinogen

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Metabolic activation of carcinogenic aristolochic acid, a risk factor for Balkan endemic nephropathy.

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Biotransformation enzymes in development of renal injury and urothelial cancer caused by aristolochic acid

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanisms of the different DNA adduct forming potentials of the urban air pollutants 2-nitrobenzanthrone and carcinogenic 3-nitrobenzanthrone

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Misuse of herbal remedies: the case of an outbreak of terminal renal failure in Belgium (Chinese herbs nephropathy)

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Rapidly progressive interstitial renal fibrosis in young women: association with slimming regimen including Chinese herbs

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Kinetic and docking studies of the interaction of quinones with the quinone reductase active site

1 reference

https://api.crossref.org/works/10.1002%2FEM.20642

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1002/EM.20642

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21370283%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21370283%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q61775759&oldid=1740309094"