(Q37765653)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20553493%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

review article

1 reference

title

Linking environmental carcinogen exposure to TP53 mutations in human tumours using the human TP53 knock-in (Hupki) mouse model (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20553493%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20553493%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

David H. Phillips

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20553493%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

author name string

Jill E Kucab

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20553493%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

language of work or name

English

0 references

publication date

1 June 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20553493%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20553493%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

volume

277

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20553493%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

issue

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20553493%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

page(s)

2567-2583

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20553493%20AND%20SRC:MED&resulttype=core&format=json

Environmental exposure measurement in cancer epidemiology

5 February 2020

cites work

1 reference

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Polycyclic aromatic hydrocarbons in the diet.

21 January 2018

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21 January 2018

The Hallmarks of Cancer

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Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

21 January 2018

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Investigating human cancer etiology by DNA lesion footprinting and mutagenicity analysis.

21 January 2018

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Complicating the complexity of p53

21 January 2018

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Tumor spectrum analysis in p53-mutant mice

21 January 2018

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The p53-Mdm2 module and the ubiquitin system.

21 January 2018

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The role of p53 in hypoxia-induced apoptosis

21 January 2018

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21 January 2018

Modes of p53 regulation

1 reference

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Transcriptional regulation by p53: one protein, many possibilities

21 January 2018

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Transcriptional control of human p53-regulated genes

21 January 2018

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The p53 tumor suppressor participates in multiple cell cycle checkpoints

21 January 2018

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The transcriptional targets of p53 in apoptosis control

21 January 2018

1 reference

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Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database

21 January 2018

1 reference

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p53 mutations in human cancers

21 January 2018

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A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma

21 January 2018

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Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers.

21 January 2018

1 reference

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Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers

21 January 2018

1 reference

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On the origin of G --> T transversions in lung cancer

21 January 2018

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TP53 and liver carcinogenesis.

21 January 2018

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Hepatocellular carcinoma: from gene to public health.

21 January 2018

1 reference

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Aristolochic acid mutagenesis: molecular clues to the aetiology of Balkan endemic nephropathy-associated urothelial cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Aristolochic acid and the etiology of endemic (Balkan) nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

p53 mutational spectra and the role of methylated CpG sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Mutagenic and epigenetic effects of DNA methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Cytosine methylation determines hot spots of DNA damage in the human P53 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

TP53 mutations in human cancers: functional selection and impact on cancer prognosis and outcomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Origins and selection of p53 mutations in lung carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Knock-in mice with a chimeric human/murine p53 gene develop normally and show wild-type p53 responses to DNA damaging agents: a new biomedical research tool.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Human p53 knock-in (hupki) mice do not differ in liver tumor response from their counterparts with murine p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Genotoxicity of 3-nitrobenzanthrone and 3-aminobenzanthrone in MutaMouse and lung epithelial cells derived from MutaMouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Preferential repair and strand-specific repair of benzo[a]pyrene diol epoxide adducts in the HPRT gene of diploid human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

MEF immortalization to investigate the ins and outs of mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Extension of life-span by introduction of telomerase into normal human cells

21 January 2018

1 reference

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Understanding transformation: progress and gaps

21 January 2018

1 reference

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Wild-type and Hupki (human p53 knock-in) murine embryonic fibroblasts: p53/ARF pathway disruption in spontaneous escape from senescence

21 January 2018

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Human tumor p53 mutations are selected for in mouse embryonic fibroblasts harboring a humanized p53 gene

21 January 2018

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p53 mutations in benzo(a)pyrene-exposed human p53 knock-in murine fibroblasts correlate with p53 mutations in human lung tumors

21 January 2018

1 reference

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Further studies with a cell immortalization assay to investigate the mutation signature of aristolochic acid in human p53 sequences

21 January 2018

1 reference

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Common tumour p53 mutations in immortalized cells from Hupki mice heterozygous at codon 72.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

TP53 mutation signature supports involvement of aristolochic acid in the aetiology of endemic nephropathy-associated tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

The carcinogenic air pollutant 3-nitrobenzanthrone induces GC to TA transversion mutations in human p53 sequences.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

21 January 2018

1 reference

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Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Targeting of lung cancer mutational hotspots by polycyclic aromatic hydrocarbons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Slow repair of bulky DNA adducts along the nontranscribed strand of the human p53 gene may explain the strand bias of transversion mutations in cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Air pollution and cancer: biomarker studies in human populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

The presence of mutagens/carcinogens in the excised lung and analysis of lung cancer induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

3-Nitrobenzanthrone, a Powerful Bacterial Mutagen and Suspected Human Carcinogen Found in Diesel Exhaust and Airborne Particulates

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

DNA adduct and tumor formations in rats after intratracheal administration of the urban air pollutant 3-nitrobenzanthrone

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

3-Nitrobenzanthrone, a potential human cancer hazard in diesel exhaust and urban air pollution: a review of the evidence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Environmental pollutant and potent mutagen 3-nitrobenzanthrone forms DNA adducts after reduction by NAD(P)H:quinone oxidoreductase and conjugation by acetyltransferases and sulfotransferases in human hepatic cytosols

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Metabolic activation of the environmental contaminant 3-nitrobenzanthrone by human acetyltransferases and sulfotransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Identification of three major DNA adducts formed by the carcinogenic air pollutant 3-nitrobenzanthrone in rat lung at the C8 and N2 position of guanine and at the N6 position of adenine

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

DNA adducts and mutagenic specificity of the ubiquitous environmental pollutant 3-nitrobenzanthrone in Muta Mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Mutations in the lungs of gpt delta transgenic mice following inhalation of diesel exhaust.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

In vivo mutagenesis in the lungs of gpt-delta transgenic mice treated intratracheally with 1,6-dinitropyrene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Aristolochic acid nephropathy: a worldwide problem

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi)

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Late onset of bladder urothelial carcinoma after kidney transplantation for end-stage aristolochic acid nephropathy: a case series with 15-year follow-up

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Urothelial malignant disease and Chinese herbal nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Is aristolochic acid a risk factor for Balkan endemic nephropathy-associated urothelial cancer?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Metabolic activation of carcinogenic aristolochic acid, a risk factor for Balkan endemic nephropathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

DNA adducts and p53 mutations in a patient with aristolochic acid-associated nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Sequence-specific detection of aristolochic acid-DNA adducts in the human p53 gene by terminal transferase-dependent PCR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Homozygous deletion of glycogen synthase kinase 3beta bypasses senescence allowing Ras transformation of primary murine fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Cellular senescence bypass screen identifies new putative tumor suppressor genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Endogenous DNA damage in humans: a review of quantitative data

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Development and characterization of a stable epithelial cell line from Muta™Mouse lung

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mice humanized for CYP1A1 and CYP1A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Humanized mouse lines and their application for prediction of human drug metabolism and toxicological risk assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Induction of DNA adducts and mutations in spleen, liver and lung of XPA-deficient/lacZ transgenic mice after oral treatment with benzo[a]pyrene: correlation with tumour development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Phenacetin acts as a weak genotoxic compound preferentially in the kidney of DNA repair deficient Xpa mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Xeroderma pigmentosum p48 gene enhances global genomic repair and suppresses UV-induced mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Aflatoxin-B exposure does not lead to p53 mutations but results in enhanced liver cancer of Hupki (human p53 knock-in) mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Mouse models for generating P53 gene mutation spectra

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

New approaches to understanding p53 gene tumor mutation spectra

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

The polyproline region of p53 is required to activate apoptosis but not growth arrest.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

p53 polymorphisms: cancer implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

The codon 72 polymorphic variants of p53 have markedly different apoptotic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

The different apoptotic potential of the p53 codon 72 alleles increases with age and modulates in vivo ischaemia-induced cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

A common polymorphism acts as an intragenic modifier of mutant p53 behaviour

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

The p53 codon 72 proline allele is associated with p53 gene mutations in non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

TP53 mutation, allelism and survival in non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

Increased risk of non-small cell lung cancer and frequency of somatic TP53 gene mutations in Pro72 carriers of TP53 Arg72Pro polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

A review of human carcinogens—Part A: pharmaceuticals

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2010.07676.X

10.1111/J.1742-4658.2010.07676.X

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20553493%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1 reference