(Q36664974)

15 August 2017

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title

The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis (English)

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15 August 2017

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Daniel W Nebert

1

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PubMed ID

17128211

15 August 2017

Timothy P Dalton

series ordinal

2

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PubMed ID

17128211

15 August 2017

language of work or name

English

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publication date

1 December 2006

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15 August 2017

Nature Reviews Cancer

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15 August 2017

6

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15 August 2017

947-960

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15 August 2017

12

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https://scigraph.springernature.com/pub.10.1038/nrc2015

15 August 2017

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cites work

Clinical importance of the cytochromes P450

1 reference

Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants

21 January 2018

1 reference

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

21 January 2018

2 references

21 January 2018

12 December 2020

Free radicals, metals and antioxidants in oxidative stress-induced cancer

1 reference

8-Oxoguanine DNA damage: at the crossroad of alternative repair pathways.

21 January 2018

1 reference

Pharmacokinetic variability of anticancer agents

21 January 2018

1 reference

Pharmacogenomics: translating functional genomics into rational therapeutics

21 January 2018

1 reference

The metabolism of certain drugs and food chemicals in man

21 January 2018

1 reference

Pharmacogenomics and "individualized drug therapy": high expectations and disappointing achievements

21 January 2018

1 reference

A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancer.

21 January 2018

1 reference

Redox regulation of vascular prostanoid synthesis by the nitric oxide-superoxide system.

21 January 2018

1 reference

The P450 gene superfamily: recommended nomenclature.

21 January 2018

1 reference

Proposed role of drug-metabolizing enzymes: regulation of steady state levels of the ligands that effect growth, homeostasis, differentiation, and neuroendocrine functions

21 January 2018

1 reference

The evolution of drug metabolism

21 January 2018

1 reference

Pharmacogenetics of cytochrome P450 and its applications in drug therapy: the past, present and future

21 January 2018

1 reference

Advances in pharmacogenomics and individualized drug therapy: exciting challenges that lie ahead

21 January 2018

1 reference

Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine

21 January 2018

1 reference

Prooxidant states and tumor promotion

21 January 2018

1 reference

The Ah locus: genetic differences in toxicity, cancer, mutation, and birth defects

21 January 2018

1 reference

Some observations on the oxidation phenotype status of Nigerian patients presenting with cancer

21 January 2018

1 reference

Polymorphic hydroxylation of Debrisoquine in man.

21 January 2018

1 reference

Oxidants and signaling by mitogen-activated protein kinases in lung epithelium

21 January 2018

1 reference

Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer

21 January 2018

1 reference

Oncogenic signaling pathways activated in DMBA-induced mouse mammary tumors.

21 January 2018

1 reference

Modulation of oestrogen receptor signalling by association with the activated dioxin receptor

21 January 2018

1 reference

Aromatic hydrocarbon receptor interaction with the retinoblastoma protein potentiates repression of E2F-dependent transcription and cell cycle arrest

21 January 2018

1 reference

The aryl hydrocarbon receptor predisposes hepatocytes to Fas-mediated apoptosis

21 January 2018

1 reference

Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis

21 January 2018

1 reference

Role of polymorphic human cytochrome P450 enzymes in estrone oxidation.

21 January 2018

1 reference

Molecular genetics of primary congenital glaucoma

21 January 2018

1 reference

Drug-metabolizing enzymes in ligand-modulated transcription

21 January 2018

1 reference

Prostaglandins and leukotrienes: advances in eicosanoid biology

21 January 2018

1 reference

Interrelationships between cyclooxygenases and aromatase: unraveling the relevance of cyclooxygenase inhibitors in breast cancer

21 January 2018

1 reference

Mechanisms leading to COX-2 expression and COX-2 induced tumorigenesis: topical therapeutic strategies targeting COX-2 expression and activity

21 January 2018

1 reference

Prostaglandin E synthase: a novel drug target for inflammation and cancer

21 January 2018

1 reference

Role of TGFbeta in skin inflammation and carcinogenesis

21 January 2018

1 reference

At the crossroads of inflammation and cancer

21 January 2018

1 reference

CAR, the continuously advancing receptor, in drug metabolism and disease

21 January 2018

1 reference

LXRS and FXR: the yin and yang of cholesterol and fat metabolism

21 January 2018

1 reference

Liver X receptors as integrators of metabolic and inflammatory signaling

21 January 2018

1 reference

The role of the immune system in the pathophysiology of osteoporosis

21 January 2018

1 reference

Nuclear receptors and lipid physiology: opening the X-files

21 January 2018

1 reference

Retinoic acids repress constitutive active receptor-mediated induction by 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene of the CYP2B10 gene in mouse primary hepatocytes

21 January 2018

1 reference

The mutagenic hazards of aquatic sediments: a review.

21 January 2018

1 reference

Short-chain fatty acids enhance nuclear receptor activity through mitogen-activated protein kinase activation and histone deacetylase inhibition.

21 January 2018

1 reference

Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis

21 January 2018

1 reference

Enzyme-catalysed reactions of polycyclic hydrocarbons with deoxyribonucleic acid and protein in vitro

21 January 2018

1 reference

Targeted knockout of Cyp1a1 gene does not alter hepatic constitutive expression of other genes in the mouse [Ah] battery

21 January 2018

1 reference

Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism

21 January 2018

1 reference

Cytochrome P450 CYP1B1 determines susceptibility to 7, 12-dimethylbenz[a]anthracene-induced lymphomas

21 January 2018

1 reference

Liver deformation in Ahr-null mice: evidence for aberrant hepatic perfusion in early development

21 January 2018

1 reference

Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor

21 January 2018

1 reference

Oral exposure to benzo[a]pyrene in the mouse: detoxication by inducible cytochrome P450 is more important than metabolic activation

21 January 2018

1 reference

Oral benzo[a]pyrene in Cyp1 knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required for immune damage independent of total-body burden and clearance rate

21 January 2018

1 reference

4-aminobiphenyl-induced liver and urinary bladder DNA adduct formation in Cyp1a2(-/-) and Cyp1a2(+/+) mice

21 January 2018

1 reference

Mouse lung CYP1A1 catalyzes the metabolic activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

21 January 2018

1 reference

For dioxin-induced birth defects, mouse or human CYP1A2 in maternal liver protects whereas mouse CYP1A1 and CYP1B1 are inconsequential

21 January 2018

1 reference

Human drug-metabolizing enzyme polymorphisms: effects on risk of toxicity and cancer

21 January 2018

1 reference

Synergy and antagonism of promiscuous inhibition in multiple-compound mixtures

21 January 2018

1 reference

Polymorphisms of human nuclear receptors that control expression of drug-metabolizing enzymes

21 January 2018

1 reference

CHEK2 is a multiorgan cancer susceptibility gene

21 January 2018

1 reference

The BARD1 Cys557Ser variant and breast cancer risk in Iceland

21 January 2018

1 reference

Cytochrome P450 and the individuality of species

21 January 2018

1 reference

Presystemic Drug Elimination

21 January 2018

1 reference

SITES OF INITIAL REMOVAL OF CHYLOMICRON TRIGLYCERIDE FATTY ACIDS FROM THE BLOOD.

21 January 2018

1 reference

METABOLISM OF CONSTITUENT LIPIDS OF DOG CHYLOMICRONS

21 January 2018

1 reference

Macrophages, macrophage foam cells, and eccentric intimal thickening in the coronary arteries of young children.

21 January 2018

1 reference

McCollum Award Lecture, 1992: vitamin A absorption, transport, cellular uptake, and storage

21 January 2018

1 reference

Regeneration of serotonin from 5-methoxytryptamine by polymorphic human CYP2D6.

21 January 2018

1 reference

Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus

21 January 2018

1 reference

Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mice humanized for CYP1A1 and CYP1A2.

21 January 2018

1 reference

Theophylline pharmacokinetics: comparison of Cyp1a1(-/-) and Cyp1a2(-/-) knockout mice, humanized hCYP1A1_1A2 knock-in mice lacking either the mouse Cyp1a1 or Cyp1a2 gene, and Cyp1(+/+) wild-type mice.

21 January 2018

1 reference

Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse

21 January 2018

1 reference

Genetic engineering using homologous recombination

21 January 2018

1 reference

Studies on the metabolism of benzo[a]pyrene and dose-dependent differences in the mutagenic profile of its ultimate carcinogenic metabolite

21 January 2018

1 reference

The toxicology of hydroquinone--relevance to occupational and environmental exposure

21 January 2018

1 reference

Effect of UDP-glucuronic acid on the microsome-mediated binding of benzo(a)pyrene metabolites to calf thymus DNA.

21 January 2018

1 reference

Glutathione conjugate mediated toxicities

21 January 2018

1 reference

The role of glutathione reductase in the cytotoxicity of chromium (VI) in isolated rat hepatocytes

21 January 2018

1 reference

Pretreatment of rats with the inducing agents phenobarbitone and 3-methylcholanthrene ameliorates the toxicity of chromium (VI) in hepatocytes

21 January 2018

1 reference

Reductive activation of Cr(Vi) by nitric oxide synthase

21 January 2018

1 reference

Glutathione-dependent reduction of arsenate in human erythrocytes--a process independent of purine nucleoside phosphorylase

21 January 2018

1 reference

Reduction of arsenate to arsenite by human erythrocyte lysate and rat liver cytosol - characterization of a glutathione- and NAD-dependent arsenate reduction linked to glycolysis

21 January 2018

1 reference

Effect of an inactivator of glyceraldehyde-3-phosphate dehydrogenase, a fortuitous arsenate reductase, on disposition of arsenate in rats

21 January 2018

1 reference

Glutathione S-transferase omega 1 and omega 2 pharmacogenomics

21 January 2018

1 reference

Levels and membrane localization of the c-K-ras p21 protein in lungs of mice of different genetic strains and effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and Aroclor 1254.

21 January 2018

1 reference

Catalase enzyme mutations and their association with diseases

21 January 2018

1 reference

Does G6PD deficiency protect against cancer? A critical review

21 January 2018

1 reference

N-acetyltransferase 2 genetic polymorphism: effects of carcinogen and haplotype on urinary bladder cancer risk

21 January 2018

1 reference

Is the association between cigarette smoking and breast cancer modified by genotype? A review of epidemiologic studies and meta-analysis

21 January 2018

1 reference

Cytochrome P450 gene polymorphism and cancer

21 January 2018

1 reference

Cytochrome P450 pharmacogenetics and cancer.

21 January 2018

1 reference

Modulation of paraoxonase (PON1) activity

21 January 2018

1 reference

Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology

21 January 2018

2 references

21 January 2018

12 December 2020

Pharmacogenetics of human cytosolic sulfotransferases

1 reference

Contribution of NAD(P)H:quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors

21 January 2018

1 reference

EPHX1 polymorphisms and the risk of lung cancer: a HuGE review

21 January 2018

1 reference

Glutathione s-transferase polymorphisms (GSTM1, GSTP1 and GSTT1) and the risk of acute leukaemia: a systematic review and meta-analysis

21 January 2018

1 reference

Genetic polymorphisms of glutathione S-transferases and the risk of adult brain tumors: a meta-analysis

21 January 2018

1 reference

Polymorphism of UDP-glucuronosyltransferase and drug metabolism

21 January 2018

1 reference

Xenobiotic-metabolizing cytochromes P450 convert prostaglandin endoperoxide to hydroxyheptadecatrienoic acid and the mutagen, malondialdehyde.

21 January 2018

1 reference

Vascular protective effects of cytochrome p450 epoxygenase-derived eicosanoids

21 January 2018

1 reference

Cloning and characterization of CYP4F21: a prostaglandin E2 20-hydroxylase of ram seminal vesicles

21 January 2018

1 reference

Evaluation of cytochrome P450 4 family as mediator of phospholipase D activation in aortic vascular smooth muscle cells

21 January 2018

1 reference

Inter-individual susceptibility to environmental toxicants--a current assessment

21 January 2018

1 reference

Induction of phase I, II and III drug metabolism/transport by xenobiotics

21 January 2018

1 reference

Nuclear receptors and drug disposition gene regulation

21 January 2018

1 reference

Regulation of hepatic transporters by xenobiotic receptors

21 January 2018

1 reference

Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network

21 January 2018

1 reference

Rapid clearance of hexachlorobenzene from chylomicrons

21 January 2018

1 reference

Search for an association between the human CYP1A2 genotype and CYP1A2 metabolic phenotype

21 January 2018

1 reference

Metabolic oxidation phenotypes as markers for susceptibility to lung cancer

21 January 2018

1 reference

Microsomal cytochrome P450 and eicosanoid metabolism

21 January 2018

1 reference

Squamous cell carcinomas fail to respond to the prodifferentiating actions of 1,25(OH)2D: why?

31 March 2020

1 reference

Effects of dietary constituents on the metabolism of chemical carcinogens

31 March 2020

1 reference

12 December 2020

Cytochrome P450: evolution and functional diversity.

1 reference

12 December 2020

Hepatic uptake of chylomicron remnants

1 reference

12 December 2020

CYP2D6 genotyping and the association with lung cancer susceptibility

1 reference

12 December 2020

GSTT1 and GSTM1 deletions, NQO1 C609T polymorphism and risk of chronic myelogenous leukemia in Japanese.

1 reference

12 December 2020

Polymorphisms in drug-metabolizing enzymes: what is their clinical relevance and why do they exist?

1 reference

12 December 2020

Positive correlation between high aryl hydrocarbon hydroxylase activity and primary lung cancer as analyzed in cryopreserved lymphocytes

1 reference

12 December 2020

Cigarette smoking, N-acetyltransferase 2 genetic polymorphisms, and breast cancer risk

1 reference

12 December 2020

Lung cancer risk, occupational exposure, and the debrisoquine metabolic phenotype

1 reference

12 December 2020

Current cellular assays for measuring clinical drug metabolizing capacity--impact of new molecular biologic techniques.

1 reference

12 December 2020

Roles of cytochrome P-450 enzymes in chemical carcinogenesis and cancer chemotherapy.

1 reference

12 December 2020

Identification of the antibiotic hops component, colupulone, as an inducer of hepatic cytochrome P-4503A in the mouse

1 reference

12 December 2020

Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.

1 reference

12 December 2020

Methodological issues in the interpretation of studies of the CYP2D6 genotype in relation to lung cancer risk

1 reference

12 December 2020

Biological reactive intermediates that mediate chromium (VI) toxicity

1 reference

12 December 2020

A new cytochrome in liver microsomes

1 reference

12 December 2020

Possible role of genetic predisposition in multigeneration carcinogenesis

1 reference

12 December 2020

[Formation of fluoroacetyl-coenzyme A and fluoroacetylcholine from fluoroacetic acid and fluorocitric acid in brain extracts]

1 reference

12 December 2020

Metabolic susceptibility to agricultural pesticides and non-Hodgkin's lymphoma.

1 reference

12 December 2020

Role of cytochrome P4501A2 in chemical carcinogenesis: implications for human variability in expression and enzyme activity.

1 reference

12 December 2020

Drug metabolism and signal transduction: possible role of Ah receptor and arachidonic acid cascade in protection from ethanol toxicity

1 reference

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NRC2015

1 reference

15 August 2017

1 reference

PubMed ID

17128211