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Pharmacogenomics of Human Uridine Diphospho-Glucuronosyltransferases and Clinical Implications
scientific article published on 12 June 2014
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Europe PubMed Central
PubMed publication ID
24922307
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24922307%20AND%20SRC:MED&resulttype=core&format=json
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20 March 2020
title
Pharmacogenomics of human uridine diphospho-glucuronosyltransferases and clinical implications
(English)
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Europe PubMed Central
PubMed publication ID
24922307
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24922307%20AND%20SRC:MED&resulttype=core&format=json
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20 March 2020
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pharmacogenomics
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author
Chantal Guillemette
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1
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Europe PubMed Central
PubMed publication ID
24922307
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20 March 2020
author name string
É Lévesque
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2
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24922307
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20 March 2020
M Rouleau
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3
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24922307
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English
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publication date
12 June 2014
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PubMed publication ID
24922307
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retrieved
20 March 2020
published in
Clinical Pharmacology & Therapeutics
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Europe PubMed Central
PubMed publication ID
24922307
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20 March 2020
volume
96
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PubMed publication ID
24922307
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20 March 2020
issue
3
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PubMed publication ID
24922307
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20 March 2020
page(s)
324-339
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20 March 2020
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Epigenetic regulation is a crucial factor in the repression of UGT1A1 expression in the human kidney.
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Regulation of UDP-glucuronosyltransferase 1A1 expression and activity by microRNA 491-3p
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Genetic diversity at the UGT1 locus is amplified by a novel 3' alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity
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The UDP-glucuronosyltransferase (UGT) 1A polymorphism c.2042C>G (rs8330) is associated with increased human liver acetaminophen glucuronidation, increased UGT1A exon 5a/5b splice variant mRNA ratio, and decreased risk of unintentional acetaminophen-
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Immunohistochemical expression of conjugating UGT1A-derived isoforms in normal and tumoral drug-metabolizing tissues in humans
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Polymorphisms and haplotypes of the UDP-glucuronosyltransferase 2B7 gene promoter.
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Quantitative analysis of UDP-glucuronosyltransferase (UGT) 1A and UGT2B expression levels in human livers.
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Limited influence of UGT1A1*28 and no effect of UGT2B7*2 polymorphisms on UGT1A1 or UGT2B7 activities and protein expression in human liver microsomes
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Modulation of the UGT2B7 enzyme activity by C-terminally truncated proteins derived from alternative splicing
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Expression of UGT2B7 is driven by two mutually exclusive promoters and alternative splicing in human tissues: changes from prenatal life to adulthood and in kidney cancer
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Single nucleotide polymorphism discovery and functional assessment of variation in the UDP-glucuronosyltransferase 2B7 gene
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Targeted quantitative proteomics for the analysis of 14 UGT1As and -2Bs in human liver using NanoUPLC-MS/MS with selected reaction monitoring
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Optimized methods for targeted peptide-based quantification of human uridine 5'-diphosphate-glucuronosyltransferases in biological specimens using liquid chromatography-tandem mass spectrometry.
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Differential allelic expression of c.1568C > A at UGT2B15 is due to variation in a novel cis-regulatory element in the 3'UTR.
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Quantitative distribution of mRNAs encoding the 19 human UDP-glucuronosyltransferase enzymes in 26 adult and 3 fetal tissues.
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based on heuristic
inferred from DOI database lookup
Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCLPT.2014.126
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Determination of mRNA Expression of Human UDP-Glucuronosyltransferases and Application for Localization in Various Human Tissues by Real-Time Reverse Transcriptase-Polymerase Chain Reaction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FCLPT.2014.126
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/CLPT.2014.126
1 reference
stated in
Europe PubMed Central
PubMed publication ID
24922307
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24922307%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 March 2020
PubMed publication ID
24922307
1 reference
stated in
Europe PubMed Central
PubMed publication ID
24922307
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24922307%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 March 2020
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