(Q62853309)

English

The activation of the Nrf2/ARE pathway in HepG2 hepatoma cells by phytochemicals and subsequent modulation of phase II and antioxidant enzyme expression

scientific article published on 25 March 2015

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scholarly article

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25800511%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

The activation of the Nrf2/ARE pathway in HepG2 hepatoma cells by phytochemicals and subsequent modulation of phase II and antioxidant enzyme expression (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25800511%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

hepatocellular carcinoma

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

Jaroslaw Paluszczak

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25800511%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Wanda Baer-Dubowska

4

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25800511%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Violetta Krajka-Kuzniak

object named as

Violetta Krajka-Kuźniak

1

0 references

3

object named as

Hanna Szaefer

1 reference

Europe PubMed Central

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3 March 2020

publication date

25 March 2015

1 reference

Europe PubMed Central

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3 March 2020

Journal of Physiology and Biochemistry

1 reference

Europe PubMed Central

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3 March 2020

71

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3 March 2020

2

1 reference

Europe PubMed Central

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3 March 2020

227-238

1 reference

Europe PubMed Central

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3 March 2020

https://scigraph.springernature.com/pub.10.1007/s13105-015-0401-4

0 references

Nrf2 signaling in coordinated activation of antioxidant gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/25800511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mammalian class theta GST and differential susceptibility to carcinogens: a review

1 reference

https://pubmed.ncbi.nlm.nih.gov/25800511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-performance liquid chromatography-based determination of total isothiocyanate levels in human plasma: application to studies with 2-phenethyl isothiocyanate

1 reference

https://pubmed.ncbi.nlm.nih.gov/25800511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemoprotection against cancer by induction of phase 2 enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/25800511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

1 reference

https://pubmed.ncbi.nlm.nih.gov/25800511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular mechanism of human Nrf2 activation and degradation: role of sequential phosphorylation by protein kinase CK2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25800511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nrf2 as a target for cancer chemoprevention

1 reference

https://pubmed.ncbi.nlm.nih.gov/25800511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals

1 reference

https://pubmed.ncbi.nlm.nih.gov/25800511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of naturally occurring phenolic acids on the expression of glutathione S-transferase isozymes in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25800511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of cytochrome P450 and phase II enzymes by protocatechuic acid in mouse liver and kidney

1 reference

https://pubmed.ncbi.nlm.nih.gov/25800511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quercetin protects human hepatoma HepG2 against oxidative stress induced by tert-butyl hydroperoxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/25800511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of Nrf2 and JNK1 in the activation of antioxidant responsive element (ARE) by chemopreventive agent phenethyl isothiocyanate (PEITC)

1 reference

https://pubmed.ncbi.nlm.nih.gov/25800511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flavonoids and phenolic acids from cranberry juice are bioavailable and bioactive in healthy older adults.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25800511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/25800511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Method for analysis of tannic acid and its metabolites in biological samples: application to tannic acid metabolism in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25800511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective effect of tannic acid on the brain of adult rats exposed to cadmium and lead

1 reference

https://pubmed.ncbi.nlm.nih.gov/25800511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of polyphenol bioavailability in rat small intestine

1 reference

https://pubmed.ncbi.nlm.nih.gov/25800511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of rat hepatic and kidney phase II enzymes by cabbage juices: comparison with the effects of indole-3-carbinol and phenethyl isothiocyanate

1 reference

https://pubmed.ncbi.nlm.nih.gov/25800511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear factor-erythroid 2-related factor 2 as a chemopreventive target in colorectal cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25800511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of hepatic antioxidant enzymes by phenolic acids in rats is accompanied by increased levels of multidrug resistance-associated protein 3 mRNA expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/25800511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25800511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic and extrahepatic expression of glutathione S-transferase isozymes in mice and its modulation by naturally occurring phenolic acids

1 reference

https://pubmed.ncbi.nlm.nih.gov/25800511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacodynamics of dietary phytochemical indoles I3C and DIM: Induction of Nrf2-mediated phase II drug metabolizing and antioxidant genes and synergism with isothiocyanates.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25800511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of carcinogenesis by tea.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25800511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic polymorphism and function of glutathione S-transferases in tumor drug resistance.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25800511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nrf2 as a novel molecular target for chemoprevention

1 reference

https://pubmed.ncbi.nlm.nih.gov/25800511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tannic acid potently inhibits tumor cell proteasome activity, increases p27 and Bax expression, and induces G1 arrest and apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25800511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antioxidant enzymes and human diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/25800511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemoprevention through the Keap1-Nrf2 signaling pathway by phase 2 enzyme inducers

1 reference

https://pubmed.ncbi.nlm.nih.gov/25800511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein measurement with the Folin phenol reagent

1 reference

https://pubmed.ncbi.nlm.nih.gov/25800511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of 3-methylcholanthrene-induced rat hepatic and renal cytochrome P450 and phase II enzymes by plant phenols: protocatechuic and tannic acids

1 reference

https://pubmed.ncbi.nlm.nih.gov/25800511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential expression and stability of endogenous nuclear factor E2-related factor 2 (Nrf2) by natural chemopreventive compounds in HepG2 human hepatoma cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25800511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the Nrf2-ARE signaling pathway: a promising strategy in cancer prevention

1 reference

https://pubmed.ncbi.nlm.nih.gov/25800511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/25800511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase II enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25800511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural influence of isothiocyanates on expression of cytochrome P450, phase II enzymes, and activation of Nrf2 in primary rat hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/25800511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transactivation of genes encoding for phase II enzymes and phase III transporters by phytochemical antioxidants.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25800511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipid peroxidation and cell cycle signaling: 4-hydroxynonenal, a key molecule in stress mediated signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/25800511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Xanthohumol induces phase II enzymes via Nrf2 in human hepatocytes in vitro.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25800511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulatory mechanisms controlling gene expression mediated by the antioxidant response element

1 reference

https://pubmed.ncbi.nlm.nih.gov/25800511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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