(Q63407070)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30995507%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

title

Transforming Growth Factor-β Signaling in Immunity and Cancer (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30995507%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

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1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30995507%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

author name string

Joan Massagué

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30995507%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

language of work or name

English

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publication date

1 April 2019

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4 May 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30995507%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

volume

50

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30995507%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

page(s)

924-940

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4 May 2020

issue

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30995507%20AND%20SRC:MED&resulttype=core&format=json

Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

4 May 2020

cites work

1 reference

12 December 2020

Transforming growth factor beta 1 suppression of c-myc gene transcription: role in inhibition of keratinocyte proliferation

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12 December 2020

Rapid onset synovial inflammation and hyperplasia induced by transforming growth factor beta

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12 December 2020

Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand

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12 December 2020

Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta

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12 December 2020

Single IL-2-secreting precursor CD4 T cell can develop into either Th1 or Th2 cytokine secretion phenotype

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12 December 2020

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

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12 December 2020

p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

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12 December 2020

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death

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12 December 2020

Transforming growth factor beta and cyclosporin A inhibit the inducible activity of the interleukin-2 gene in T cells through a noncanonical octamer-binding site

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12 December 2020

Transforming growth factor beta enhances integrin expression and type IV collagenase secretion in human monocytes

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12 December 2020

A transcriptional partner for MAD proteins in TGF-beta signalling

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12 December 2020

Autoimmunity associated with TGF-beta1-deficiency in mice is dependent on MHC class II antigen expression

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12 December 2020

TGF-beta attenuates the class II transactivator and reveals an accessory pathway of IFN-gamma action.

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12 December 2020

Identification of distinct regions of 5' flanking DNA that mediate constitutive, IFN-gamma, STAT1, and TGF-beta-regulated expression of the class II transactivator gene.

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12 December 2020

Thrombospondin-1 is a major activator of TGF-beta1 in vivo

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12 December 2020

Transforming growth factor beta1 inhibits Fas ligand expression and subsequent activation-induced cell death in T cells via downregulation of c-Myc

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12 December 2020

TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development

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12 December 2020

Beta 2-microglobulin-deficient background ameliorates lethal phenotype of the TGF-beta 1 null mouse

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12 December 2020

Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease

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12 December 2020

Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells

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12 December 2020

Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells

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12 December 2020

Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways

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12 December 2020

Transforming growth factor-beta stimulates parathyroid hormone-related protein and osteolytic metastases via Smad and mitogen-activated protein kinase signaling pathways

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12 December 2020

Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation

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12 December 2020

E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression

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12 December 2020

Transforming growth factor beta 1 inhibits expression of NKp30 and NKG2D receptors: consequences for the NK-mediated killing of dendritic cells

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12 December 2020

Transforming growth factor beta blocks Tec kinase phosphorylation, Ca2+ influx, and NFATc translocation causing inhibition of T cell differentiation

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12 December 2020

A multigenic program mediating breast cancer metastasis to bone

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12 December 2020

Control of Effector CD8 + T Cell Function by the Transcription Factor Eomesodermin

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12 December 2020

Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

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12 December 2020

TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia

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12 December 2020

Smad3 is essential for TGF-beta 1 to suppress IL-2 production and TCR-induced proliferation, but not IL-2-induced proliferation

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12 December 2020

Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation

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12 December 2020

Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7

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12 December 2020

Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1.

1 reference

12 December 2020

Elevated TGF-beta1 secretion and down-modulation of NKG2D underlies impaired NK cytotoxicity in cancer patients.

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12 December 2020

p21Cip1 and p27Kip1 act in synergy to alter the sensitivity of naive T cells to TGF-beta-mediated G1 arrest through modulation of IL-2 responsiveness.

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12 December 2020

Transforming growth factor beta-induced cell cycle arrest of human hematopoietic cells requires p57KIP2 up-regulation.

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12 December 2020

TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling.

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12 December 2020

Transforming growth factor-beta differentially inhibits MyD88-dependent, but not TRAM- and TRIF-dependent, lipopolysaccharide-induced TLR4 signaling.

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12 December 2020

Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo

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12 December 2020

Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity

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12 December 2020

Analysis of transforming growth factor-beta1-induced Ig germ-line gamma2b transcription and its implication for IgA isotype switching.

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12 December 2020

Adoptive transfer of tumor-reactive transforming growth factor-beta-insensitive CD8+ T cells: eradication of autologous mouse prostate cancer.

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12 December 2020

Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity

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12 December 2020

TGF-beta 1 attenuates the acquisition and expression of effector function by tumor antigen-specific human memory CD8 T cells

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12 December 2020

Transforming growth factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma

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12 December 2020

TGF-beta 1 uses distinct mechanisms to inhibit IFN-gamma expression in CD4+ T cells at priming and at recall: differential involvement of Stat4 and T-bet

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12 December 2020

TGF-{beta}-dependent CD103 expression by CD8(+) T cells promotes selective destruction of the host intestinal epithelium during graft-versus-host disease

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12 December 2020

Non-Smad TGF-beta signals

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12 December 2020

Tumor cells convert immature myeloid dendritic cells into TGF-beta-secreting cells inducing CD4+CD25+ regulatory T cell proliferation

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12 December 2020

TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance

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12 December 2020

Pro- and antiinflammatory cytokine signaling: reciprocal antagonism regulates interferon-gamma production by human natural killer cells.

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12 December 2020

Smad4 signalling in T cells is required for suppression of gastrointestinal cancer.

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12 December 2020

Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation

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12 December 2020

Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1.

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12 December 2020

Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms

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12 December 2020

Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor

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12 December 2020

Type, density, and location of immune cells within human colorectal tumors predict clinical outcome

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12 December 2020

Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer

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12 December 2020

SMAD4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion

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12 December 2020

Smad7 binds to the adaptors TAB2 and TAB3 to block recruitment of the kinase TAK1 to the adaptor TRAF2.

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12 December 2020

T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation

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12 December 2020

TGF-beta 1 regulates antigen-specific CD4+ T cell responses in the periphery

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12 December 2020

TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA

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12 December 2020

Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis

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12 December 2020

Loss of TGFbeta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia

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12 December 2020

Antagonistic nature of T helper 1/2 developmental programs in opposing peripheral induction of Foxp3+ regulatory T cells

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12 December 2020

Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix

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12 December 2020

Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer

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12 December 2020

Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis

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12 December 2020

TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function

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12 December 2020

TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4

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12 December 2020

Contextual regulation of inflammation: a duet by transforming growth factor-beta and interleukin-10.

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12 December 2020

A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells

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12 December 2020

SMAD proteins control DROSHA-mediated microRNA maturation

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12 December 2020

The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner

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12 December 2020

Cutting edge: Autocrine TGF-beta sustains default tolerogenesis by IDO-competent dendritic cells.

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12 December 2020

TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta

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12 December 2020

Role of Ras signaling in the induction of snail by transforming growth factor-beta.

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12 December 2020

Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs

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12 December 2020

Human dendritic cells produce TGF-beta 1 under the influence of lung carcinoma cells and prime the differentiation of CD4+CD25+Foxp3+ regulatory T cells

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12 December 2020

Tumor-derived TGF-beta mediates conversion of CD4+Foxp3+ regulatory T cells in a murine model of pancreas cancer

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12 December 2020

GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells

1 reference

12 December 2020

Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor kappaB.

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12 December 2020

Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN

1 reference

12 December 2020

Immunotherapy for human renal cell carcinoma by adoptive transfer of autologous transforming growth factor beta-insensitive CD8+ T cells

1 reference

12 December 2020

TGF-beta downregulates the activating receptor NKG2D on NK cells and CD8+ T cells in glioma patients

1 reference

12 December 2020

Smad2 and Smad3 are redundantly essential for the TGF-beta-mediated regulation of regulatory T plasticity and Th1 development.

1 reference

12 December 2020

TGF-beta signaling specifies axons during brain development

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12 December 2020

Inactivation of chemokine (C-C motif) receptor 1 (CCR1) suppresses colon cancer liver metastasis by blocking accumulation of immature myeloid cells in a mouse model.

1 reference

12 December 2020

The polarization of immune cells in the tumour environment by TGFbeta

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12 December 2020

Smad2 positively regulates the generation of Th17 cells.

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12 December 2020

Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells

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12 December 2020

TGF-β limits IL-33 production and promotes the resolution of colitis through regulation of macrophage function

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12 December 2020

Latent TGF-β structure and activation

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12 December 2020

T cell surveillance of oncogene-induced prostate cancer is impeded by T cell-derived TGF-β1 cytokine

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12 December 2020

Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells

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12 December 2020

Induction of heart valve lesions by small-molecule ALK5 inhibitors.

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12 December 2020

Smad4 deficiency in T cells leads to the Th17-associated development of premalignant gastroduodenal lesions in mice

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12 December 2020

Smad6-specific recruitment of Smurf E3 ligases mediates TGF-β1-induced degradation of MyD88 in TLR4 signalling

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12 December 2020

Master transcription factors determine cell-type-specific responses to TGF-β signaling

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12 December 2020

Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration

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12 December 2020

GARP regulates the bioavailability and activation of TGFβ.

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12 December 2020

Epithelial cells utilize cortical actin/myosin to activate latent TGF-β through integrin α(v)β(6)-dependent physical force

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12 December 2020

Gr-1+CD11b+ cells are responsible for tumor promoting effect of TGF-β in breast cancer progression

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12 December 2020

TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation

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12 December 2020

TGF-β is responsible for NK cell immaturity during ontogeny and increased susceptibility to infection during mouse infancy

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12 December 2020

Dendritic cell-specific disruption of TGF-β receptor II leads to altered regulatory T cell phenotype and spontaneous multiorgan autoimmunity

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12 December 2020

TGFβ signalling in context

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12 December 2020

Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis initiation

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12 December 2020

The harmonies played by TGF-β in stem cell biology

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12 December 2020

Absence of signaling into CD4⁺ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3⁺ regulatory T cells.

1 reference

12 December 2020

Interleukin-21 (IL-21) synergizes with IL-2 to enhance T-cell receptor-induced human T-cell proliferation and counteracts IL-2/transforming growth factor-β-induced regulatory T-cell development.

1 reference

12 December 2020

Inflammation-mediated genetic and epigenetic alterations drive cancer development in the neighboring epithelium upon stromal abrogation of TGF-β signaling

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12 December 2020

Higher frequencies of GARP(+)CTLA-4(+)Foxp3(+) T regulatory cells and myeloid-derived suppressor cells in hepatocellular carcinoma patients are associated with impaired T-cell functionality

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12 December 2020

TGF-β signaling in myeloid cells is required for tumor metastasis

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12 December 2020

Type III TGF-β receptor downregulation generates an immunotolerant tumor microenvironment.

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12 December 2020

Blockade of TGF-β signaling greatly enhances the efficacy of TCR gene therapy of cancer

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12 December 2020

Transforming growth factor-β signaling controls the formation and maintenance of gut-resident memory T cells by regulating migration and retention

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12 December 2020

TGF-β signalling is required for CD4⁺ T cell homeostasis but dispensable for regulatory T cell function

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12 December 2020

Activin receptor-like kinase5 inhibition suppresses mouse melanoma by ubiquitin degradation of Smad4, thereby derepressing eomesodermin in cytotoxic T lymphocytes

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12 December 2020

TGF-β activation and function in immunity

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12 December 2020

TGF-β-inducible microRNA-183 silences tumor-associated natural killer cells.

1 reference

12 December 2020

Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis

1 reference

12 December 2020

Cardiac Safety of TGF-β Receptor I Kinase Inhibitor LY2157299 Monohydrate in Cancer Patients in a First-in-Human Dose Study

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12 December 2020

Stromal contribution to the colorectal cancer transcriptome.

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12 December 2020

Stromal gene expression defines poor-prognosis subtypes in colorectal cancer.

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12 December 2020

TGFβ Is a Master Regulator of Radiation Therapy-Induced Antitumor Immunity

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12 December 2020

Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo.

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12 December 2020

Id1 suppresses anti-tumour immune responses and promotes tumour progression by impairing myeloid cell maturation

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12 December 2020

Structural determinants of Smad function in TGF-β signaling.

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12 December 2020

The prognostic landscape of genes and infiltrating immune cells across human cancers

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12 December 2020

The consensus molecular subtypes of colorectal cancer

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12 December 2020

T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate.

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12 December 2020

TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway

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12 December 2020

TGF-β Tumor Suppression through a Lethal EMT.

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12 December 2020

Marfan Syndrome and Related Disorders: 25 Years of Gene Discovery.

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12 December 2020

Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT.

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12 December 2020

Transforming Growth Factor-β Signaling Guides the Differentiation of Innate Lymphoid Cells in Salivary Glands

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12 December 2020

Neutrophils in cancer: neutral no more.

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12 December 2020

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12 December 2020

Signaling Receptors for TGF-β Family Members

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12 December 2020

TGF-β and VEGF cooperatively control the immunotolerant tumor environment and the efficacy of cancer immunotherapies

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12 December 2020

Immunoregulation by members of the TGFβ superfamily

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12 December 2020

The p53 Family Coordinates Wnt and Nodal Inputs in Mesendodermal Differentiation of Embryonic Stem Cells.

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12 December 2020

Surface Expression of TGFβ Docking Receptor GARP Promotes Oncogenesis and Immune Tolerance in Breast Cancer

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12 December 2020

Myeloid-Derived Suppressor Cells

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12 December 2020

TGF-β, Bone Morphogenetic Protein, and Activin Signaling and the Tumor Microenvironment

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12 December 2020

TGF-β Family Signaling in Embryonic and Somatic Stem-Cell Renewal and Differentiation

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12 December 2020

Regulation of the Immune Response by TGF-β: From Conception to Autoimmunity and Infection

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12 December 2020

Suppressive IL-17A+Foxp3+ and ex-Th17 IL-17AnegFoxp3+ Treg cells are a source of tumour-associated Treg cells

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12 December 2020

Foxh1 Occupies cis-Regulatory Modules Prior to Dynamic Transcription Factor Interactions Controlling the Mesendoderm Gene Program.

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12 December 2020

Regulation of Innate and Adaptive Immunity by TGFβ.

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12 December 2020

TGF-β1 Signaling and Tissue Fibrosis

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12 December 2020

TGF-β in inflammatory bowel disease: a key regulator of immune cells, epithelium, and the intestinal microbiota

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12 December 2020

Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells.

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12 December 2020

SMAD4 impedes the conversion of NK cells into ILC1-like cells by curtailing non-canonical TGF-β signaling

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12 December 2020

Platelets subvert T cell immunity against cancer via GARP-TGFβ axis.

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12 December 2020

Targeting latency-associated peptide promotes antitumor immunity.

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12 December 2020

Blockade of surface-bound TGF-β on regulatory T cells abrogates suppression of effector T cell function in the tumor microenvironment

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12 December 2020

Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin αVβ8.

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12 December 2020

Tumor-Specific T-Cells Engineered to Overcome Tumor Immune Evasion Induce Clinical Responses in Patients With Relapsed Hodgkin Lymphoma.

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12 December 2020

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells.

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12 December 2020

TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis.

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12 December 2020

Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy.

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12 December 2020

Focal Irradiation And Systemic Transforming Growth Factor β Blockade in Metastatic Breast Cancer.

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12 December 2020

CD103+ Tumor-Resident CD8+ T Cells Are Associated with Improved Survival in Immunotherapy-Naïve Melanoma Patients and Expand Significantly During Anti-PD-1 Treatment

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12 December 2020

Contextual determinants of TGFβ action in development, immunity and cancer.

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12 December 2020

A Unidirectional Transition from Migratory to Perivascular Macrophage Is Required for Tumor Cell Intravasation.

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12 December 2020

Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade.

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12 December 2020

A Milieu Molecule for TGF-β Required for Microglia Function in the Nervous System

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12 December 2020

Resident memory T cells, critical components in tumor immunology

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12 December 2020

Galunisertib plus gemcitabine vs. gemcitabine for first-line treatment of patients with unresectable pancreatic cancer

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12 December 2020

Integrin αvβ8-expressing tumor cells evade host immunity by regulating TGF-β activation in immune cells

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12 December 2020

Human monocytes and macrophages regulate immune tolerance via integrin αvβ8-mediated TGFβ activation

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12 December 2020

Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells

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12 December 2020

TGF-β-associated extracellular matrix genes link cancer-associated fibroblasts to immune evasion and immunotherapy failure

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12 December 2020

Preclinical Evaluation of AZ12601011 and AZ12799734, Inhibitors of Transforming Growth Factor β Superfamily Type 1 Receptors

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12 December 2020

Simultaneous Loss of Both Atypical Protein Kinase C Genes in the Intestinal Epithelium Drives Serrated Intestinal Cancer by Impairing Immunosurveillance

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12 December 2020

TGFβ Blockade Enhances Radiotherapy Abscopal Efficacy Effects in Combination with Anti-PD1 and Anti-CD137 Immunostimulatory Monoclonal Antibodies

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12 December 2020

α-PD-1 therapy elevates Treg/Th balance and increases tumor cell pSmad3 that are both targeted by α-TGFβ antibody to promote durable rejection and immunity in squamous cell carcinomas

1 reference

12 December 2020

10.1016/J.IMMUNI.2019.03.024

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30995507%20AND%20SRC:MED&resulttype=core&format=json

4 May 2020

1 reference