(Q63805283)

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Supplementation of a suboptimal protein dose with leucine or essential amino acids: effects on myofibrillar protein synthesis at rest and following resistance exercise in men

article by Tyler A Churchward-Venne et al published 1 June 2012 in Journal of Physiology

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scholarly article

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Supplementation of a suboptimal protein dose with leucine or essential amino acids: effects on myofibrillar protein synthesis at rest and following resistance exercise in men (English)

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Cameron Mitchell

object named as

Cameron J Mitchell

3

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object named as

Andrew Philp

5

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Nicholas A Burd

object named as

Nicholas A Burd

2

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Stuart M. Phillips

object named as

Stuart M Phillips

9

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author name string

Tyler A Churchward-Venne

1

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Daniel W D West

4

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George R Marcotte

6

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Steven K Baker

7

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Keith Baar

8

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language of work or name

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publication date

1 June 2012

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Journal of Physiology

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590

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11

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2751-65

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Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leucine regulates translation initiation in rat skeletal muscle via enhanced eIF4G phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

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Leucine as a regulator of whole body and skeletal muscle protein metabolism in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin signaling and the general amino acid control response. Two distinct pathways to amino acid synthesis and uptake.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Essential amino acids and muscle protein recovery from resistance exercise

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Orally administered leucine enhances protein synthesis in skeletal muscle of diabetic rats in the absence of increases in 4E-BP1 or S6K1 phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resistance exercise-induced increases in putative anabolic hormones do not enhance muscle protein synthesis or intracellular signalling in young men.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiological rise in plasma leucine stimulates muscle protein synthesis in neonatal pigs by enhancing translation initiation factor activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

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An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

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Skeletal muscle amino acid transporter expression is increased in young and older adults following resistance exercise.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

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Latency and duration of stimulation of human muscle protein synthesis during continuous infusion of amino acids

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

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Heated dorsal hand vein sampling for metabolic studies: a reappraisal

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential stimulation of myofibrillar and sarcoplasmic protein synthesis with protein ingestion at rest and after resistance exercise

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Orally administered leucine stimulates protein synthesis in skeletal muscle of postabsorptive rats in association with increased eIF4F formation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amino acid transceptors: gate keepers of nutrient exchange and regulators of nutrient signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Baseline measurements for stable isotope studies: an alternative to biopsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prolonged Leucine Supplementation Does Not Augment Muscle Mass or Affect Glycemic Control in Elderly Type 2 Diabetic Men

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The leucine content of a complete meal directs peak activation but not duration of skeletal muscle protein synthesis and mammalian target of rapamycin signaling in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resistance exercise decreases eIF2Bepsilon phosphorylation and potentiates the feeding-induced stimulation of p70S6K1 and rpS6 in young men.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resistance exercise volume affects myofibrillar protein synthesis and anabolic signalling molecule phosphorylation in young men.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ingested protein dose response of muscle and albumin protein synthesis after resistance exercise in young men.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increase in anterior tibialis muscle protein synthesis in healthy man during mixed amino acid infusion: studies of incorporation of [1-13C]leucine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Validation of a single biopsy approach and bolus protein feeding to determine myofibrillar protein synthesis in stable isotope tracer studies in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disassociation between the effects of amino acids and insulin on signaling, ubiquitin ligases, and protein turnover in human muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coordinated collagen and muscle protein synthesis in human patella tendon and quadriceps muscle after exercise

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Consumption of fluid skim milk promotes greater muscle protein accretion after resistance exercise than does consumption of an isonitrogenous and isoenergetic soy-protein beverage

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Low-load high volume resistance exercise stimulates muscle protein synthesis more than high-load low volume resistance exercise in young men.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term leucine supplementation does not increase muscle mass or strength in healthy elderly men.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of flooding amino acids on incorporation of labeled amino acids into human muscle protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mammalian target of rapamycin complex 1 activation is required for the stimulation of human skeletal muscle protein synthesis by essential amino acids

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pyruvate suppresses PGC1alpha expression and substrate utilization despite increased respiratory chain content in C2C12 myotubes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leucine. A possible regulator of protein turnover in muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid aminoacidemia enhances myofibrillar protein synthesis and anabolic intramuscular signaling responses after resistance exercise

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Postexercise net protein synthesis in human muscle from orally administered amino acids.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flooding with L-[1-13C]leucine stimulates human muscle protein incorporation of continuously infused L-[1-13C]valine

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nonessential amino acids are not necessary to stimulate net muscle protein synthesis in healthy volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leucine supplementation enhances skeletal muscle recovery in rats following exercise

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activating transcription factor 4.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein synthesis rates in human muscles: neither anatomical location nor fibre-type composition are major determinants

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Co-ingestion of leucine with protein does not further augment post-exercise muscle protein synthesis rates in elderly men

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An increase in essential amino acid availability upregulates amino acid transporter expression in human skeletal muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bolus arginine supplementation affects neither muscle blood flow nor muscle protein synthesis in young men at rest or after resistance exercise

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leucine stimulates protein synthesis in skeletal muscle of neonatal pigs by enhancing mTORC1 activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Branched-chain amino acids as fuels and anabolic signals in human muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the transcription factor ATF4 in the anabolic actions of insulin and the anti-anabolic actions of glucocorticoids

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased rates of muscle protein turnover and amino acid transport after resistance exercise in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct anabolic signalling responses to amino acids in C2C12 skeletal muscle cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leucine supplementation improves muscle protein synthesis in elderly men independently of hyperaminoacidaemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Co-ingestion of protein and leucine stimulates muscle protein synthesis rates to the same extent in young and elderly lean men.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of cardiac and skeletal muscle protein synthesis by individual branched-chain amino acids in neonatal pigs

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ingestion of whey hydrolysate, casein, or soy protein isolate: effects on mixed muscle protein synthesis at rest and following resistance exercise in young men.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Excess leucine intake enhances muscle anabolic signaling but not net protein anabolism in young men and women

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human muscle protein synthesis is modulated by extracellular, not intramuscular amino acid availability: a dose-response study

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combined ingestion of protein and free leucine with carbohydrate increases postexercise muscle protein synthesis in vivo in male subjects.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oral leucine administration stimulates protein synthesis in rat skeletal muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Muscle full effect after oral protein: time-dependent concordance and discordance between human muscle protein synthesis and mTORC1 signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of muscle anabolism by resistance exercise and ingestion of leucine plus protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/22451437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1113/JPHYSIOL.2012.228833

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