(Q64012993)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23588322%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

title

Model-based drug development: a rational approach to efficiently accelerate drug development (English)

1 reference

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28 February 2020

author name string

P A Milligan

1

1 reference

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28 February 2020

M J Brown

2

1 reference

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28 February 2020

B Marchant

3

1 reference

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28 February 2020

S W Martin

4

1 reference

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28 February 2020

P H van der Graaf

5

1 reference

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28 February 2020

N Benson

6

1 reference

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28 February 2020

G Nucci

7

1 reference

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28 February 2020

D J Nichols

8

1 reference

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28 February 2020

R A Boyd

9

1 reference

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28 February 2020

J W Mandema

10

1 reference

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28 February 2020

S Krishnaswami

11

1 reference

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28 February 2020

S Zwillich

12

1 reference

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28 February 2020

D Gruben

13

1 reference

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28 February 2020

R J Anziano

14

1 reference

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28 February 2020

T C Stock

15

1 reference

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28 February 2020

R L Lalonde

16

1 reference

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28 February 2020

language of work or name

English

0 references

publication date

14 March 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23588322%20AND%20SRC:MED&resulttype=core&format=json

Clinical Pharmacology & Therapeutics

28 February 2020

published in

1 reference

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28 February 2020

volume

93

1 reference

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28 February 2020

issue

6

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28 February 2020

page(s)

502-514

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https://scigraph.springernature.com/pub.10.1038/clpt.2013.54

28 February 2020

exact match

0 references

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Long-term use of gonadotropin-releasing hormone analogs and hormone replacement therapy in the management of endometriosis: a randomized trial with a 6-year follow-up

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One year comparison between two add-back therapies in patients treated with a GnRH agonist for symptomatic endometriosis: a randomized double-blind trial

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Integrated pharmacometrics and systems pharmacology model-based analyses to guide GnRH receptor modulator development for management of endometriosis

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Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions

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Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor

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Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain

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7 January 2021

Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival

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7 January 2021

Cross-membrane signal transduction of receptor tyrosine kinases (RTKs): from systems biology to systems pharmacology

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An efficient randomised, placebo-controlled clinical trial with the irreversible fatty acid amide hydrolase-1 inhibitor PF-04457845, which modulates endocannabinoids but fails to induce effective analgesia in patients with pain due to osteoarthritis

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Systems pharmacology of the nerve growth factor pathway: use of a systems biology model for the identification of key drug targets using sensitivity analysis and the integration of physiology and pharmacology

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7 January 2021

Has the time come for predictive computer modeling in CNS drug discovery and development?

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7 January 2021

Multiscale kinetic modeling of liposomal Doxorubicin delivery quantifies the role of tumor and drug-specific parameters in local delivery to tumors

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7 January 2021

A mechanistic, model-based approach to safety assessment in clinical development

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7 January 2021

Inhibition of renal glucose reabsorption: a novel strategy for achieving glucose control in type 2 diabetes mellitus

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7 January 2021

Diabetes area participation analysis: a review of companies and targets described in the 2008 - 2010 patent literature

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7 January 2021

Efficacy and safety of SGLT2 inhibitors in the treatment of type 2 diabetes mellitus

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Supplementation with goldenseal (Hydrastis canadensis), but not kava kava (Piper methysticum), inhibits human CYP3A activity in vivo

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7 January 2021

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7 January 2021

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