(Q37998313)

26 August 2017

Inhibiting the breakdown of endogenous opioids and cannabinoids to alleviate pain (English)

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26 August 2017

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Bernard P Roques

1

1 reference

PubMed ID

22460123

26 August 2017

Marie-Claude Fournié-Zaluski

series ordinal

2

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PubMed ID

22460123

26 August 2017

Michel Wurm

series ordinal

3

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26 August 2017

1 April 2012

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Nature Reviews Drug Discovery

26 August 2017

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26 August 2017

11

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26 August 2017

4

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26 August 2017

292-310

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https://scigraph.springernature.com/pub.10.1038/nrd3673

26 August 2017

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cites work

Human brain mechanisms of pain perception and regulation in health and disease.

1 reference

Cellular and Molecular Mechanisms of Pain

31 March 2020

1 reference

The Cell and Molecular Basis of Mechanical, Cold, and Inflammatory Pain

31 March 2020

1 reference

Dysfunction of endogenous pain inhibition during exercise with painful muscles in patients with shoulder myalgia and fibromyalgia

31 March 2020

1 reference

Loss of peripheral morphine analgesia contributes to the reduced effectiveness of systemic morphine in neuropathic pain

31 March 2020

1 reference

NK1 (substance P) receptor antagonists--why are they not analgesic in humans?

31 March 2020

1 reference

A multicenter, double-blind, randomized, placebo-controlled crossover evaluation of a short course of 4030W92 in patients with chronic neuropathic pain

31 March 2020

1 reference

A randomized, double-blind, placebo-controlled trial of a glycine antagonist in neuropathic pain

31 March 2020

1 reference

The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept

31 March 2020

1 reference

31 March 2020

1 reference

The enkephalinase inhibitor thiorphan shows antinociceptive activity in mice

31 March 2020

1 reference

Prevalence of opioid adverse events in chronic non-malignant pain: systematic review of randomised trials of oral opioids

31 March 2020

1 reference

Adverse effects of medical cannabinoids: a systematic review

31 March 2020

1 reference

Mu and delta receptors belong to a family of receptors that are coupled to potassium channels

31 March 2020

1 reference

Pain responses, anxiety and aggression in mice deficient in pre-proenkephalin

31 March 2020

1 reference

Use of preproenkephalin knockout mice and selective inhibitors of enkephalinases to investigate the role of enkephalins in various behaviours.

31 March 2020

1 reference

Analgesia induced in vivo by central administration of enkephalin in rat

31 March 2020

1 reference

In vitro methionine5-enkephalin degradation kinetics by human brain preparations

31 March 2020

1 reference

State-dependent opioid control of pain

31 March 2020

1 reference

The enkephalinase inhibitor, GB 52, does not affect nociceptive flexion reflexes nor pain sensation in humans

31 March 2020

1 reference

Analgesic effects of kelatorphan, a new highly potent inhibitor of multiple enkephalin degrading enzymes

31 March 2020

1 reference

Potent antinociceptive effects of kelatorphan (a highly efficient inhibitor of multiple enkephalin-degrading enzymes) systemically administered in normal and arthritic rats

31 March 2020

1 reference

RB101-mediated protection of endogenous opioids: potential therapeutic utility?

31 March 2020

1 reference

Protection of endogenous enkephalin catabolism as natural approach to novel analgesic and antidepressant drugs.

31 March 2020

1 reference

Enkephalinase inhibitors: potential agents for the management of pain

31 March 2020

1 reference

Involvement of enkephalins in the inhibition of osteosarcoma-induced thermal hyperalgesia evoked by the blockade of peripheral P2X3 receptors

31 March 2020

1 reference

The endocannabinoid system and pain

31 March 2020

1 reference

Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

31 March 2020

1 reference

Enzymatic pathways that regulate endocannabinoid signaling in the nervous system

31 March 2020

1 reference

A catalytically silent FAAH-1 variant drives anandamide transport in neurons

31 March 2020

1 reference

Role of endogenous cannabinoids in synaptic signaling

31 March 2020

1 reference

Modulation of opioids via protection of anandamide degradation by fatty acid amide hydrolase

31 March 2020

1 reference

Functional disassociation of the central and peripheral fatty acid amide signaling systems

31 March 2020

1 reference

Modulation of anxiety through blockade of anandamide hydrolysis

31 March 2020

1 reference

Mice lacking fatty acid amide hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesia

31 March 2020

1 reference

The endogenous cannabinoid system protects against colonic inflammation

31 March 2020

1 reference

An endocannabinoid mechanism for stress-induced analgesia.

31 March 2020

1 reference

Changes in spinal and supraspinal endocannabinoid levels in neuropathic rats.

31 March 2020

1 reference

A decrease in anandamide signaling contributes to the maintenance of cutaneous mechanical hyperalgesia in a model of bone cancer pain

31 March 2020

1 reference

Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain

31 March 2020

1 reference

Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism.

31 March 2020

1 reference

Targeting the endocannabinoid system: to enhance or reduce?

31 March 2020

1 reference

Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling

31 March 2020

1 reference

Structure of aminopeptidase N from Escherichia coli complexed with the transition-state analogue aminophosphinic inhibitor PL250

31 March 2020

1 reference

Structural analysis of neprilysin with various specific and potent inhibitors

31 March 2020

1 reference

Crystal Structure of Fatty Acid Amide Hydrolase Bound to the Carbamate Inhibitor URB597: Discovery of a Deacylating Water Molecule and Insight into Enzyme Inactivation

31 March 2020

1 reference

First discrete autoradiographic distribution of aminopeptidase N in various structures of rat brain and spinal cord using the selective iodinated inhibitor [125I]RB 129.

31 March 2020

1 reference

Ontogenic and adult whole body distribution of aminopeptidase N in rat investigated by in vitro autoradiography.

31 March 2020

1 reference

Neutral endopeptidase 24.11 in rat peripheral tissues: comparative localization by 'ex vivo' and 'in vitro' autoradiography.

31 March 2020

1 reference

Novel approaches to targeting neuropeptide systems

31 March 2020

1 reference

Site-specific increases in peripheral cannabinoid receptors and their endogenous ligands in a model of neuropathic pain.

31 March 2020

1 reference

Morphine directly inhibits nociceptors in inflamed skin

31 March 2020

1 reference

Opioids and sensory nerves

31 March 2020

1 reference

Endocannabinoids and related compounds: walking back and forth between plant natural products and animal physiology

31 March 2020

1 reference

Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors

31 March 2020

1 reference

Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors

31 March 2020

1 reference

Antinociceptive response induced by mixed inhibitors of enkephalin catabolism in peripheral inflammation.

31 March 2020

1 reference

Attacking pain at its source: new perspectives on opioids

31 March 2020

1 reference

The role of the endogenous cannabinoid system in peripheral analgesia

31 March 2020

1 reference

Mu and delta opioid receptors on nociceptors attenuate mechanical hyperalgesia in rat.

31 March 2020

1 reference

Relative contribution of peripheral versus central opioid receptors to antinociception

31 March 2020

1 reference

Targeting fatty acid amide hydrolase (FAAH) to treat pain and inflammation

31 March 2020

1 reference

Inhibition of osteosarcoma-induced thermal hyperalgesia in mice by the orally active dual enkephalinase inhibitor PL37. Potentiation by gabapentin

31 March 2020

1 reference

Antinociceptive and anti-allodynic effects of oral PL37, a complete inhibitor of enkephalin-catabolizing enzymes, in a rat model of peripheral neuropathic pain induced by vincristine

31 March 2020

1 reference

Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor

31 March 2020

1 reference

International Union of Pharmacology. XXVII. Classification of cannabinoid receptors

31 March 2020

1 reference

The state of GPCR research in 2004.

31 March 2020

1 reference

Modulation of transmitter release via presynaptic cannabinoid receptors

31 March 2020

1 reference

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene

31 March 2020

1 reference

Physiological control of emotion-related behaviors by endogenous enkephalins involves essentially the delta opioid receptors

31 March 2020

1 reference

Further evidence for the interaction of mu- and delta-opioid receptors in the antinociceptive effects of the dual inhibitor of enkephalin catabolism, RB101(S). A spinal c-Fos protein study in the rat under carrageenin inflammation

31 March 2020

1 reference

Delta-opioid mediated inhibitions of acute and prolonged noxious-evoked responses in rat dorsal horn neurones

31 March 2020

1 reference

Coexpression of delta- and mu-opioid receptors in nociceptive sensory neurons.

31 March 2020

1 reference

Endogenous opiates and nociception: a possible functional role in both pain inhibition and detection as revealed by intrathecal naloxone

31 March 2020

1 reference

A neuropeptide courier for delta-opioid receptors?

31 March 2020

1 reference

The complications of promiscuity: endocannabinoid action and metabolism

31 March 2020

1 reference

The molecular logic of endocannabinoid signalling

31 March 2020

1 reference

From endocannabinoid profiling to 'endocannabinoid therapeutics'.

31 March 2020

1 reference

Role of ionotropic cannabinoid receptors in peripheral antinociception and antihyperalgesia

31 March 2020

1 reference

Levels, metabolism, and pharmacological activity of anandamide in CB(1) cannabinoid receptor knockout mice: evidence for non-CB(1), non-CB(2) receptor-mediated actions of anandamide in mouse brain

31 March 2020

1 reference

Anandamide excites central terminals of dorsal root ganglion neurons via vanilloid receptor-1 activation.

31 March 2020

1 reference

Cannabinoids go nuclear: evidence for activation of peroxisome proliferator-activated receptors.

31 March 2020

1 reference

Inhibition of fatty acid amide hydrolase and cyclooxygenase-2 increases levels of endocannabinoid related molecules and produces analgesia via peroxisome proliferator-activated receptor-alpha in a model of inflammatory pain

31 March 2020

1 reference

Oxidative metabolism of endocannabinoids by COX-2.

31 March 2020

1 reference

A physiological role for endocannabinoid-derived products of cyclooxygenase-2-mediated oxidative metabolism

31 March 2020

1 reference

Neuropeptides: opportunities for drug discovery

31 March 2020

1 reference

Characterization and inhibition of a cholecystokinin-inactivating serine peptidase

31 March 2020

1 reference

Effect of bradykinin metabolism inhibitors on evoked hypotension in rats: rank efficacy of enzymes associated with bradykinin-mediated angioedema

31 March 2020

1 reference

Dynorphin A(1-17) biotransformation in striatum of freely moving rats using microdialysis and matrix-assisted laser desorption/ionization mass spectrometry

31 March 2020

1 reference

Extracellular biotransformation of beta-endorphin in rat striatum and cerebrospinal fluid

31 March 2020

1 reference

Angiotensin converting enzyme (ACE) and neprilysin hydrolyze neuropeptides: a brief history, the beginning and follow-ups to early studies

31 March 2020

1 reference

Effect of peptidases on the ability of exogenous and endogenous neurokinins to produce neurokinin 1 receptor internalization in the rat spinal cord

31 March 2020

1 reference

Oleoylethanolamide, an endogenous PPAR-alpha agonist, lowers body weight and hyperlipidemia in obese rats.

31 March 2020

1 reference

The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide.

31 March 2020

1 reference

The narcotic antagonist naloxone enhances clinical pain

31 March 2020

1 reference

Placebo and opioid analgesia-- imaging a shared neuronal network

31 March 2020

1 reference

Repeated systemic administration of the mixed inhibitor of enkephalin-degrading enzymes, RB101, does not induce either antinociceptive tolerance or cross-tolerance with morphine

31 March 2020

1 reference

Assessment of physical dependence after continuous perfusion into the rat jugular vein of the mixed inhibitor of enkephalin-degrading enzymes, RB 101.

31 March 2020

1 reference

RB101(S), a dual inhibitor of enkephalinases does not induce antinociceptive tolerance, or cross-tolerance with morphine: a c-Fos study at the spinal level.

31 March 2020

1 reference

Neutral endopeptidase modulation of septic shock.

31 March 2020

1 reference

Neprilysin null mice develop exaggerated pulmonary vascular remodeling in response to chronic hypoxia

31 March 2020

1 reference

Impaired angiogenesis in aminopeptidase N-null mice

31 March 2020

1 reference

Racecadotril in the treatment of acute watery diarrhea in children

31 March 2020

1 reference

Aminopeptidase N (APN)/CD13 inhibitor, Ubenimex, enhances radiation sensitivity in human cervical cancer

31 March 2020

1 reference

Vasopeptidase inhibition: a double-edged sword?

31 March 2020

1 reference

Basal release of Met-enkephalin and neurotensin in the ventrolateral periaqueductal gray matter of the rat: a microdialysis study of antinociceptive circuits

31 March 2020

1 reference

Pain management by a new series of dual inhibitors of enkephalin degrading enzymes: long lasting antinociceptive properties and potentiation by CCK2 antagonist or methadone

31 March 2020

1 reference

Delta9-tetrahydrocannabinol releases and facilitates the effects of endogenous enkephalins: reduction in morphine withdrawal syndrome without change in rewarding effect

31 March 2020

1 reference

Chronic morphine treatment modulates the extracellular levels of endogenous enkephalins in rat brain structures involved in opiate dependence: a microdialysis study.

31 March 2020

1 reference

Changes in levels of the tripeptide Tyr-Gly-Gly as an index of enkephalin release in the spinal cord: effects of noxious stimuli and parenterally-active peptidase inhibitors

31 March 2020

1 reference

Aminophosphinic inhibitors as transition state analogues of enkephalin-degrading enzymes: a class of central analgesics

31 March 2020

1 reference

Cerebral decreases in opioid receptor binding in patients with central neuropathic pain measured by [11C]diprenorphine binding and PET.

31 March 2020

1 reference

Effects of the potent analgesic enkephalin-catabolizing enzyme inhibitors RB101 and kelatorphan on respiration

31 March 2020

1 reference

Ligand-induced mu opioid receptor endocytosis and recycling in enteric neurons

31 March 2020

1 reference

Endocannabinoids and the regulation of their levels in health and disease

31 March 2020

1 reference

Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase

31 March 2020

1 reference

Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models

31 March 2020

1 reference

The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice

31 March 2020

1 reference

Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain

31 March 2020

1 reference

Pain modulation by release of the endogenous cannabinoid anandamide

31 March 2020

1 reference

Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597): effects on anandamide and oleoylethanolamide deactivation.

31 March 2020

1 reference

Amino acid sequence of rabbit kidney neutral endopeptidase 24.11 (enkephalinase) deduced from a complementary DNA.

31 March 2020

1 reference

The moonlighting enzyme CD13: old and new functions to target

31 March 2020

1 reference

Exploration of the S(')(1) subsite of neprilysin: a joined molecular modeling and site-directed mutagenesis study

31 March 2020

1 reference

A three-dimensional construction of the active site (region 507-749) of human neutral endopeptidase (EC.3.4.24.11)

31 March 2020

1 reference

New bidentates as full inhibitors of enkephalin-degrading enzymes: synthesis and analgesic properties

31 March 2020

1 reference

Antinociceptive effect of systemic PC 12, a prodrug mixed inhibitor of enkephalin-degrading enzymes, in normal and arthritic rats

31 March 2020

1 reference

Antinociceptive effect of systemic kelatorphan, in mononeuropathic rats, involves different opioid receptor types

31 March 2020

1 reference

"Mixed inhibitor-prodrug" as a new approach toward systemically active inhibitors of enkephalin-degrading enzymes

31 March 2020

1 reference

Pain-suppressive effects on various nociceptive stimuli (thermal, chemical, electrical and inflammatory) of the first orally active enkephalin-metabolizing enzyme inhibitor RB 120.

31 March 2020

1 reference

In vivo occupation of mouse brain opioid receptors by endogenous enkephalins: blockade of enkephalin degrading enzymes by RB 101 inhibits [3H]diprenorphine binding

31 March 2020

1 reference

31 March 2020

1 reference

Enhancement of the effects of a complete inhibitor of enkephalin-catabolizing enzymes, RB 101, by a cholecystokinin-B receptor antagonist in diabetic rats

31 March 2020

1 reference

The pro-nociceptive effects of remifentanil or surgical injury in mice are associated with a decrease in delta-opioid receptor mRNA levels: Prevention of the nociceptive response by on-site delivery of enkephalins

31 March 2020

1 reference

Prodrugs: design and clinical applications.

31 March 2020

1 reference

Involvement of nitric oxide in the inhibition of bone cancer-induced hyperalgesia through the activation of peripheral opioid receptors in mice

31 March 2020

1 reference

Lack of physical dependence in mice after repeated systemic administration of the mixed inhibitor prodrug of enkephalin-degrading enzymes, RB101

31 March 2020

1 reference

Shared mechanisms for opioid tolerance and a transition to chronic pain

31 March 2020

1 reference

Development of [125I]RB104, a potent inhibitor of neutral endopeptidase 24.11, and its use in detecting nanogram quantities of the enzyme by "inhibitor gel electrophoresis".

31 March 2020

1 reference

Analgesic doses of the enkephalin degrading enzyme inhibitor RB 120 do not have discriminative stimulus properties.

31 March 2020

1 reference

Peptidases prevent mu-opioid receptor internalization in dorsal horn neurons by endogenously released opioids.

31 March 2020

1 reference

Functional dissociation of mu opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction.

31 March 2020

1 reference

Effect of inhibiting enkephalin catabolism in the VTA on motor activity and extracellular dopamine

31 March 2020

1 reference

The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).

31 March 2020

1 reference

Trifluoromethyl ketone inhibitors of fatty acid amide hydrolase: a probe of structural and conformational features contributing to inhibition

31 March 2020

1 reference

Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide

31 March 2020

1 reference

Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics

31 March 2020

1 reference

Structure-guided inhibitor design for human FAAH by interspecies active site conversion

31 March 2020

1 reference

Analgesic Effects of Fatty Acid Amide Hydrolase Inhibition in a Rat Model of Neuropathic Pain

31 March 2020

1 reference

Inhibitors of fatty acid amide hydrolase reduce carrageenan-induced hind paw inflammation in pentobarbital-treated mice: comparison with indomethacin and possible involvement of cannabinoid receptors

31 March 2020

1 reference

Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase

31 March 2020

1 reference

Inhibition of fatty acid amide hydrolase produces analgesia by multiple mechanisms

31 March 2020

1 reference

Fatty acid amide hydrolase inhibitors display broad selectivity and inhibit multiple carboxylesterases as off-targets

31 March 2020

1 reference

Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice.

31 March 2020

1 reference

CB1-cannabinoid and mu-opioid receptor co-localization on postsynaptic target in the rat dorsal horn

31 March 2020

1 reference

Interaction of the cannabinoid and opioid systems in the modulation of nociception

31 March 2020

1 reference

The mu-opioid receptor agonist morphine, but not agonists at delta- or kappa-opioid receptors, induces peripheral antinociception mediated by cannabinoid receptors

31 March 2020

1 reference

Synergistic interactions between cannabinoid and opioid analgesics

31 March 2020

1 reference

Cellular mechanisms underlying the interaction between cannabinoid and opioid system.

31 March 2020

1 reference

Cannabinoid-opioid interactions during neuropathic pain and analgesia

31 March 2020

1 reference

CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids

31 March 2020

1 reference

Participation of the opioid system in cannabinoid-induced antinociception and emotional-like responses

31 March 2020

1 reference

Facilitation of enkephalins catabolism inhibitor-induced antinociception by drugs classically used in pain management

31 March 2020

1 reference

Endocytosis of the mu opioid receptor reduces tolerance and a cellular hallmark of opiate withdrawal

31 March 2020

1 reference

Morphine and pain-related stimuli enhance cell surface availability of somatic delta-opioid receptors in rat dorsal root ganglia.

31 March 2020

1 reference

A-317491, a selective P2X3/P2X2/3 receptor antagonist, reverses inflammatory mechanical hyperalgesia through action at peripheral receptors in rats

31 March 2020

1 reference

Double-blind evaluation of transdermal nitroglycerine as adjuvant to oral morphine for cancer pain management

31 March 2020

1 reference

Peripheral mechanisms underlying the essential role of P2X3,2/3 receptors in the development of inflammatory hyperalgesia.

31 March 2020

1 reference

CI 988, an antagonist of the cholecystokinin-B receptor, potentiates endogenous opioid-mediated antinociception at spinal level

31 March 2020

1 reference

Antinociceptive effects of RB101(S), a complete inhibitor of enkephalin‐catabolizing enzymes, are enhanced by (+)‐HA966, a functional NMDA receptor antagonist: a c‐Fos study in the rat spinal cord

31 March 2020

1 reference

Synergy between enzyme inhibitors of fatty acid amide hydrolase and cyclooxygenase in visceral nociception

31 March 2020

1 reference

The neurobiology and evolution of cannabinoid signalling

31 March 2020

1 reference

Regulation of inflammatory pain by inhibition of fatty acid amide hydrolase

31 March 2020

1 reference

Peripheral opioid analgesia in experimental human pain models

31 March 2020

1 reference

Expression and G-protein coupling of mu-opioid receptors in the spinal cord and dorsal root ganglia of polyarthritic rats

31 March 2020

1 reference

Inflammation of the rat paw enhances axonal transport of opioid receptors in the sciatic nerve and increases their density in the inflamed tissue

31 March 2020

1 reference

Immune cell–derived opioids protect against neuropathic pain in mice

31 March 2020

1 reference

Mu opioid receptors and analgesia at the site of a peripheral nerve injury

31 March 2020

1 reference

Peripheral antinociceptive effects of exogenous and immune cell-derived endomorphins in prolonged inflammatory pain.

31 March 2020

1 reference

Inhibition of inflammatory pain by CRF at peripheral, spinal and supraspinal sites: involvement of areas coexpressing CRF receptors and opioid peptides

31 March 2020

1 reference

Corticotropin-releasing factor in antinociception and inflammation.

31 March 2020

1 reference

Opioid peptide-expressing leukocytes: identification, recruitment, and simultaneously increasing inhibition of inflammatory pain.

31 March 2020

1 reference

Neutral endopeptidase expression and distribution in human skin and wounds

31 March 2020

1 reference

Early exposure to chronic variable stress facilitates the occurrence of anhedonia and enhanced emotional reactions to novel stressors: reversal by naltrexone pretreatment.

31 March 2020

1 reference

Endogenous opioids as physiological antidepressants: complementary role of δ receptors and dopamine

31 March 2020

1 reference

Potential anxiolytic and antidepressant-like activities of SNC80, a selective delta-opioid agonist, in behavioral models in rodents

31 March 2020

1 reference

Antidepressant-type effects of endogenous enkephalins protected by systemic RB 101 are mediated by opioid delta and dopamine D1 receptor stimulation

31 March 2020

1 reference

Involvement of delta-opioid receptors in the effects induced by endogenous enkephalins on learned helplessness model

31 March 2020

1 reference

Facilitation of enkephalins-induced delta-opioid behavioral responses by chronic amisulpride treatment.

31 March 2020

1 reference

Behavioral and neurobiological effects of the enkephalinase inhibitor RB101 relative to its antidepressant effects

31 March 2020

1 reference

Opioid delta agonists and endogenous enkephalins induce different emotional reactivity than mu agonists after injection in the rat ventral tegmental area

31 March 2020

1 reference

Altered striatal activation predicting real-world positive affect in adolescent major depressive disorder

31 March 2020

1 reference

Absence of opiate rewarding effects in mice lacking dopamine D2 receptors

31 March 2020

1 reference

Opiates as antidepressants.

31 March 2020

1 reference

CB1 receptor knockout mice show similar behavioral modifications to wild-type mice when enkephalin catabolism is inhibited.

31 March 2020

1 reference

Facilitation of fear extinction by midbrain periaqueductal gray infusions of RB101(S), an inhibitor of enkephalin-degrading enzymes

31 March 2020

1 reference

Female preproenkephalin-knockout mice display altered emotional responses

31 March 2020

1 reference

Anxiety- and depressive-like responses and c-fos activity in preproenkephalin knockout mice: oversensitivity hypothesis of enkephalin deficit-induced posttraumatic stress disorder

31 March 2020

1 reference

Distribution of cannabinoid receptor 1 (CB1) and 2 (CB2) on sensory nerve fibers and adnexal structures in human skin

31 March 2020

1 reference

Fatty acid amide hydrolase is located preferentially in large neurons in the rat central nervous system as revealed by immunohistochemistry

31 March 2020

1 reference

Neprilysin levels in plasma and synovial fluid of juvenile idiopathic arthritis patients

31 March 2020

1 reference

The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities

31 March 2020

1 reference

Endopeptidase-24.11, a cell-surface peptidase of central nervous system neurons, is expressed by Schwann cells in the pig peripheral nervous system.

31 March 2020

1 reference

Cannabinoid receptors undergo axonal flow in sensory nerves.

31 March 2020

1 reference

Cannabinoids and the immune system: potential for the treatment of inflammatory diseases?

31 March 2020

1 reference

Control of pain initiation by endogenous cannabinoids.

31 March 2020

1 reference

Regulation of opioid binding sites in the superficial dorsal horn of the rat spinal cord following loose ligation of the sciatic nerve: comparison with sciatic nerve section and lumbar dorsal rhizotomy

31 March 2020

1 reference

Opioid receptor subtypes in the rat spinal cord: electrophysiological studies with mu- and delta-opioid receptor agonists in the control of nociception

31 March 2020

1 reference

The effects of RB101, a mixed inhibitor of enkephalin-catabolizing enzymes, on carrageenin-induced spinal c-Fos expression are completely blocked by beta-funaltrexamine, a selective mu-opioid receptor antagonist

31 March 2020

1 reference

Hypoactivity of the spinal cannabinoid system results in NMDA-dependent hyperalgesia.

31 March 2020

1 reference

Structural basis of the action of thermolysin and related zinc peptidases

31 March 2020

1 reference

Depressant effect on a C-fibre reflex in the rat, of RB101, a dual inhibitor of enkephalin-degrading enzymes.

31 March 2020

1 reference

Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity

31 March 2020

1 reference

Local application of the endocannabinoid hydrolysis inhibitor URB597 reduces nociception in spontaneous and chemically induced models of osteoarthritis

31 March 2020

1 reference

Inhibition of the enkephalin-metabolizing enzymes by the first systemically active mixed inhibitor prodrug RB 101 induces potent analgesic responses in mice and rats

31 March 2020

1 reference

12 December 2020

Chronic morphine use does not induce peripheral tolerance in a rat model of inflammatory pain

1 reference

12 December 2020

Cholecystokinin B antagonists strongly potentiate antinociception mediated by endogenous enkephalins

1 reference

12 December 2020

International Union of Pharmacology. XII. Classification of opioid receptors.

1 reference

12 December 2020

75 years of opioid research: the exciting but vain quest for the Holy Grail

1 reference

12 December 2020

The role of CCK2 receptors in the homeostasis of the opioid system

1 reference

12 December 2020

Evidence that both arginine 102 and arginine 747 are involved in substrate binding to neutral endopeptidase (EC 3.4.24.11).

1 reference

12 December 2020

Cell surface metallopeptidases involved in blood pressure regulation: structure, inhibition and clinical perspectives.

1 reference

12 December 2020

Immune cell-derived opioids protect against neuropathic pain in mice

1 reference

12 December 2020

The dual peptidase inhibitor RB101 induces a long-lasting increase in the extracellular level of Met-enkephalin-like material in the nucleus accumbens of freely moving rats

1 reference

12 December 2020

Effects of kelatorphan and other peptidase inhibitors on the in vitro and in vivo release of methionine-enkephalin-like material from the rat spinal cord

1 reference

12 December 2020

RB 101, a purported pro drug inhibitor of enkephalin metabolism, is antinociceptive in pregnant mice

1 reference

12 December 2020

Heterodimerization of mu and delta opioid receptors: A role in opiate synergy

1 reference

12 December 2020

Neutral endopeptidase 24.11: structure, inhibition, and experimental and clinical pharmacology

1 reference

12 December 2020

Assessment of anandamide interaction with the cannabinoid brain receptor: SR 141716A antagonism studies in mice and autoradiographic analysis of receptor binding in rat brain.

1 reference

12 December 2020

Human opiorphin is a naturally occurring antidepressant acting selectively on enkephalin-dependent delta-opioid pathways

1 reference

12 December 2020

Role of different brain structures in the expression of the physical morphine withdrawal syndrome

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRD3673

1 reference

26 August 2017

1 reference

PubMed ID

22460123