(Q55038697)

16 June 2018

title

The state of GPCR research in 2004. (English)

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16 June 2018

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Nature Reviews Drug Discovery GPCR Questionnaire Participants

series ordinal

1

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16 June 2018

publication date

1 July 2004

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16 June 2018

Nature Reviews Drug Discovery

published in

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16 June 2018

volume

3

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16 June 2018

issue

7

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16 June 2018

page(s)

575, 577-626

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16 June 2018

https://scigraph.springernature.com/pub.10.1038/nrd1458

exact match

0 references

cites work

Opioid receptor random mutagenesis reveals a mechanism for G protein-coupled receptor activation

1 reference

Proenkephalin A gene products activate a new family of sensory neuron--specific GPCRs

21 January 2018

1 reference

Activation of rhodopsin: new insights from structural and biochemical studies

21 January 2018

1 reference

Seven-transmembrane receptors: crystals clarify

21 January 2018

1 reference

Molecular constituents and phosphorylation-dependent regulation of the post-synaptic density

21 January 2018

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Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult

21 January 2018

1 reference

CB1 cannabinoid receptors and on-demand defense against excitotoxicity

21 January 2018

1 reference

Functionally different agonists induce distinct conformations in the G protein coupling domain of the beta 2 adrenergic receptor

21 January 2018

1 reference

Receptor-mediated activation of heterotrimeric G-proteins in living cells

21 January 2018

1 reference

Measurement of the millisecond activation switch of G protein-coupled receptors in living cells

21 January 2018

1 reference

A quantitative characterization of the yeast heterotrimeric G protein cycle

21 January 2018

1 reference

Pharmacology and physiology of human adrenergic receptor polymorphisms

21 January 2018

1 reference

PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect

21 January 2018

1 reference

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene

21 January 2018

1 reference

Opioids: first lessons from knockout mice

21 January 2018

1 reference

Uncovering molecular mechanisms involved in activation of G protein-coupled receptors

21 January 2018

1 reference

The 'magic tail' of G protein-coupled receptors: an anchorage for functional protein networks

21 January 2018

1 reference

The PDZ-binding motif of the beta2-adrenoceptor is essential for physiologic signaling and trafficking in cardiac myocytes

21 January 2018

1 reference

Involvement of chemokine receptors in breast cancer metastasis

21 January 2018

1 reference

High constitutive activity of the human formyl peptide receptor

21 January 2018

1 reference

Reconstitution of beta2-adrenoceptor-GTP-binding-protein interaction in Sf9 cells--high coupling efficiency in a beta2-adrenoceptor-G(s alpha) fusion protein

21 January 2018

1 reference

Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor

21 January 2018

1 reference

Quantitative analysis of formyl peptide receptor coupling to g(i)alpha(1), g(i)alpha(2), and g(i)alpha(3).

21 January 2018

1 reference

The human histamine H2-receptor couples more efficiently to Sf9 insect cell Gs-proteins than to insect cell Gq-proteins: limitations of Sf9 cells for the analysis of receptor/Gq-protein coupling

21 January 2018

1 reference

2'(3')-O-(N-methylanthraniloyl)-substituted GTP analogs: a novel class of potent competitive adenylyl cyclase inhibitors.

21 January 2018

1 reference

Low-affinity interactions of BODIPY-FL-GTPgammaS and BODIPY-FL-GppNHp with G(i)- and G(s)-proteins

21 January 2018

1 reference

Differential inhibition of adenylyl cyclase isoforms and soluble guanylyl cyclase by purine and pyrimidine nucleotides.

21 January 2018

1 reference

Conformation of ligands bound to the muscarinic acetylcholine receptor.

21 January 2018

1 reference

The conformation of neurotensin bound to its G protein-coupled receptor

21 January 2018

1 reference

Structure-based analysis of GPCR function: evidence for a novel pentameric assembly between the dimeric leukotriene B4 receptor BLT1 and the G-protein

21 January 2018

1 reference

Single-molecule spectroscopy of the beta(2) adrenergic receptor: observation of conformational substates in a membrane protein

21 January 2018

1 reference

Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors

21 January 2018

1 reference

Compartmentation of G protein-coupled signaling pathways in cardiac myocytes

21 January 2018

1 reference

G-protein-coupled receptor oligomerization and its potential for drug discovery

21 January 2018

1 reference

Dimerization: an emerging concept for G protein-coupled receptor ontogeny and function

21 January 2018

1 reference

Molecular tinkering of G protein-coupled receptors: an evolutionary success

21 January 2018

1 reference

Protean agonism at histamine H3 receptors in vitro and in vivo

21 January 2018

1 reference

A three-state receptor model of agonist action

21 January 2018

1 reference

Ligand-selective receptor conformations revisited: the promise and the problem

21 January 2018

1 reference

Inverse agonism gains weight

21 January 2018

1 reference

Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors

21 January 2018

1 reference

Rhodopsin: insights from recent structural studies.

21 January 2018

1 reference

Sequential binding of agonists to the beta2 adrenoceptor. Kinetic evidence for intermediate conformational states

21 January 2018

1 reference

Functional dissociation of mu opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction.

21 January 2018

1 reference

Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors

21 January 2018

1 reference

Crystal structure of rhodopsin: A G protein-coupled receptor

21 January 2018

1 reference

Organization of the G protein-coupled receptors rhodopsin and opsin in native membranes

21 January 2018

1 reference

The crystallographic model of rhodopsin and its use in studies of other G protein-coupled receptors

21 January 2018

1 reference

Mutational Analysis and Molecular Modeling of the Binding Pocket of the Metabotropic Glutamate 5 Receptor Negative Modulator 2-Methyl-6-(phenylethynyl)-pyridine

21 January 2018

1 reference

Protein-based virtual screening of chemical databases. II. Are homology models of G-Protein Coupled Receptors suitable targets?

21 January 2018

1 reference

Analysis of the mechanism by which the small-molecule CCR5 antagonists SCH-351125 and SCH-350581 inhibit human immunodeficiency virus type 1 entry.

21 January 2018

1 reference

Rhodopsin crystal: new template yielding realistic models of G-protein-coupled receptors?

21 January 2018

1 reference

21 January 2018

1 reference

Gating the selectivity filter in ClC chloride channels

21 January 2018

1 reference

The structures of BtuCD and MscS and their implications for transporter and channel function

21 January 2018

1 reference

Automated large-scale purification of a G protein-coupled receptor for neurotensin

21 January 2018

1 reference

Semliki Forest virus vectors for rapid and high-level expression of integral membrane proteins

21 January 2018

1 reference

Amino and carboxyl terminal modifications to facilitate the production and purification of a G protein-coupled receptor

21 January 2018

1 reference

Structure-based analysis of GPCR function: conformational adaptation of both agonist and receptor upon leukotriene B4 binding to recombinant BLT1.

21 January 2018

1 reference

NMR solution structure determination of membrane proteins reconstituted in detergent micelles

21 January 2018

1 reference

Differential transcriptional activation in vitro by NF-kappa B/Rel proteins

21 January 2018

1 reference

Structure and mechanism of the lactose permease of Escherichia coli

21 January 2018

1 reference

The neurokinin A receptor activates calcium and cAMP responses through distinct conformational states

21 January 2018

1 reference

G-protein-coupled receptor heterodimerization modulates receptor function

21 January 2018

1 reference

International Union of Pharmacology. XXXIII. Mammalian gamma-aminobutyric acid(B) receptors: structure and function

21 January 2018

1 reference

Distinct interactions of GTP, UTP, and CTP with G(s) proteins

21 January 2018

1 reference

GABAB receptors - the first 7TM heterodimers.

21 January 2018

1 reference

Mammalian sweet taste receptors

21 January 2018

1 reference

Receptor activity modifying proteins.

21 January 2018

1 reference

Homo- and hetero-oligomeric interactions between G-protein-coupled receptors in living cells monitored by two variants of bioluminescence resonance energy transfer (BRET): hetero-oligomers between receptor subtypes form more efficiently than between

21 January 2018

1 reference

Quantitative assessment of beta 1- and beta 2-adrenergic receptor homo- and heterodimerization by bioluminescence resonance energy transfer

21 January 2018

1 reference

Oxytocin and Vasopressin V1a and V2 Receptors Form Constitutive Homo- and Heterodimers during Biosynthesis

21 January 2018

1 reference

Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors

21 January 2018

1 reference

GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2.

21 January 2018

1 reference

Heterodimerization is required for the formation of a functional GABA(B) receptor

21 January 2018

1 reference

GABA(B)-receptor subtypes assemble into functional heteromeric complexes.

21 January 2018

1 reference

Cooperativity and oligomeric status of cardiac muscarinic cholinergic receptors

21 January 2018

1 reference

Experimental evidence for lack of homodimerization of the G protein-coupled human N-formyl peptide receptor

21 January 2018

1 reference

An amino-acid taste receptor

21 January 2018

1 reference

Regulation of opioid receptor trafficking and morphine tolerance by receptor oligomerization

21 January 2018

1 reference

Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor

21 January 2018

1 reference

A single subunit (GB2) is required for G-protein activation by the heterodimeric GABA(B) receptor

21 January 2018

1 reference

Functional significance of oligomerization of G-protein-coupled receptors.

21 January 2018

1 reference

Heterodimerization of G-protein-coupled receptors in the CNS.

21 January 2018

1 reference

Modern biomedical research: an internally self-consistent universe with little contact with medical reality?

21 January 2018

1 reference

Emerging roles for orphan G-protein-coupled receptors in the cardiovascular system

21 January 2018

1 reference

Target validation of G-protein coupled receptors

21 January 2018

1 reference

Novel approaches to targeting neuropeptide systems

21 January 2018

1 reference

Allosteric modulators of group I metabotropic glutamate receptors: novel subtype-selective ligands and therapeutic perspectives.

21 January 2018

1 reference

Allosteric modulators of G-protein-coupled receptors

21 January 2018

1 reference

Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2.

21 January 2018

1 reference

Different effects of Gsalpha splice variants on beta2-adrenoreceptor-mediated signaling. The Beta2-adrenoreceptor coupled to the long splice variant of Gsalpha has properties of a constitutively active receptor

21 January 2018

1 reference

Co-expression of the beta2-adrenoceptor and dopamine D1-receptor with Gsalpha proteins in Sf9 insect cells: limitations in comparison with fusion proteins.

21 January 2018

1 reference

Functional relevance of G-protein-coupled-receptor-associated proteins, exemplified by receptor-activity-modifying proteins (RAMPs).

21 January 2018

1 reference

Prostanoid receptors and phosphatidylinositol 3-kinase: a pathway to cancer?

21 January 2018

1 reference

G protein-coupled receptor interacting proteins: emerging roles in localization and signal transduction

21 January 2018

1 reference

Receptor activity-modifying protein 1 determines the species selectivity of non-peptide CGRP receptor antagonists

21 January 2018

1 reference

RAMPs: 5 years on, where to now?

21 January 2018

1 reference

Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors

21 January 2018

1 reference

Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer

21 January 2018

1 reference

scFv single chain antibody variable fragment as inverse agonist of the beta2-adrenergic receptor

21 January 2018

1 reference

Mechanisms of osteolytic bone metastases in breast carcinoma

21 January 2018

1 reference

Unnatural growth hormone-releasing peptide begets natural ghrelin

21 January 2018

1 reference

Antibodies inactivating mGluR1 metabotropic glutamate receptor block long-term depression in cultured Purkinje cells

21 January 2018

1 reference

Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate receptor

21 January 2018

1 reference

A genetic approach to inactivating chemokine receptors using a modified viral protein

21 January 2018

1 reference

Defective Gi protein coupling in two formyl peptide receptor mutants associated with localized juvenile periodontitis

21 January 2018

1 reference

The human formyl peptide receptor as model system for constitutively active G-protein-coupled receptors

21 January 2018

1 reference

Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects

21 January 2018

1 reference

Responsiveness to drugs and hormones in the murine model of cardiac ontogenesis

21 January 2018

1 reference

Viral exploitation and subversion of the immune system through chemokine mimicry

21 January 2018

1 reference

Neuropeptide gene polymorphisms and human behavioural disorders

21 January 2018

1 reference

Autosomal dominant hypocalcaemia caused by a Ca(2+)-sensing receptor gene mutation

21 January 2018

1 reference

Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

21 January 2018

1 reference

EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF

21 January 2018

1 reference

The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades

21 January 2018

1 reference

Nephrogenic diabetes insipidus.

21 January 2018

1 reference

A rhodopsin mutant linked to autosomal dominant retinitis pigmentosa is prone to aggregate and interacts with the ubiquitin proteasome system

21 January 2018

1 reference

Somatic and germline mutations of the TSH receptor and thyroid diseases

21 January 2018

1 reference

Genetic variations in human G protein-coupled receptors: implications for drug therapy

21 January 2018

1 reference

Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation

21 January 2018

1 reference

The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene

21 January 2018

1 reference

Leptin: defining its role in humans by the clinical study of genetic disorders

21 January 2018

1 reference

To eat or to sleep? Orexin in the regulation of feeding and wakefulness

21 January 2018

1 reference

Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice

21 January 2018

1 reference

Impaired antibacterial host defense in mice lacking the N-formylpeptide receptor

21 January 2018

1 reference

Characterization of neuropeptide Y, Y(2) receptor knockout mice in two animal models of learning and memory processing

21 January 2018

1 reference

Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation

21 January 2018

1 reference

Towards new models of disease and physiology in the neurosciences: the role of induced and naturally occurring mutations

21 January 2018

1 reference

G protein-coupled receptor allosterism and complexing

21 January 2018

1 reference

A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11

21 January 2018

1 reference

Discovery of a receptor related to the galanin receptors

21 January 2018

1 reference

Peptide E and other proenkephalin-derived peptides are potent kappa opiate receptor agonists

21 January 2018

1 reference

The G protein-coupled receptor repertoires of human and mouse

21 January 2018

1 reference

The identification of ligands at orphan G-protein coupled receptors

21 January 2018

1 reference

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

21 January 2018

1 reference

Ghrelin: an orexigenic and somatotrophic signal from the stomach

21 January 2018

1 reference

Pain responses, anxiety and aggression in mice deficient in pre-proenkephalin

21 January 2018

1 reference

A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor

21 January 2018

1 reference

Properties of Arg389-β 1 -Adrenoceptor-G sα Fusion Proteins: Comparison with Gly389-β 1 -Adrenoceptor-G sα Fusion Proteins

21 January 2018

1 reference

Richard Weinshilboum: Pharmacogenetics: The future is here!

21 January 2018

1 reference

Cognitive enhancing effects in young and old rats of pBC264, a selective CCK(B) receptor agonist.

21 January 2018

1 reference

International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on terms and symbols in quantitative pharmacology

21 January 2018

1 reference

Efficacy as a vector: the relative prevalence and paucity of inverse agonism

21 January 2018

1 reference

Inverse agonism and the regulation of receptor number

21 January 2018

1 reference

Allosteric binding sites on cell-surface receptors: novel targets for drug discovery

21 January 2018

1 reference

Efficacy at G-protein-coupled receptors

21 January 2018

1 reference

The cubic ternary complex receptor-occupancy model. III. resurrecting efficacy

21 January 2018

1 reference

G alpha 15 and G alpha 16 couple a wide variety of receptors to phospholipase C

21 January 2018

1 reference

Chimaeric G alpha proteins: their potential use in drug discovery

21 January 2018

1 reference

The Use of Receptor G-Protein Fusion Proteins for the Study of Ligand Activity

21 January 2018

1 reference

Promiscuous coupling at receptor-Galpha fusion proteins. The receptor of one covalent complex interacts with the alpha-subunit of another

21 January 2018

1 reference

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

21 January 2018

1 reference

Raster3D: photorealistic molecular graphics

21 January 2018

1 reference

Oligomerization of G-protein-coupled transmitter receptors.

21 January 2018

1 reference

G proteins and phototransduction.

21 January 2018

1 reference

Accessory proteins for G protein-signaling systems: activators of G protein signaling and other nonreceptor proteins influencing the activation state of G proteins

21 January 2018

1 reference

G protein beta gamma subunits.

21 January 2018

1 reference

G protein modulation of voltage-gated calcium channels

21 January 2018

1 reference

Cellular regulation of RGS proteins: modulators and integrators of G protein signaling

21 January 2018

1 reference

Insulin signalling: putting the 'G-' in protein-protein interactions

21 January 2018

1 reference

Potential roles of heterotrimeric G proteins of the endomembrane system

21 January 2018

1 reference

G proteins and olfactory signal transduction

21 January 2018

1 reference

Heterotrimeric G-protein betagamma-dimers in growth and differentiation

21 January 2018

1 reference

Isoforms of mammalian adenylyl cyclase: multiplicities of signaling

21 January 2018

1 reference

Inherited diseases involving g proteins and g protein-coupled receptors.

21 January 2018

1 reference

Mouse models to study G-protein-mediated signaling

21 January 2018

1 reference

NK1 Receptor Fused to beta -Arrestin Displays a Single-Component, High-Affinity Molecular Phenotype

21 January 2018

1 reference

Rhodopsin dimers in native disc membranes

21 January 2018

1 reference

GPCR-Galpha fusion proteins: molecular analysis of receptor-G-protein coupling

21 January 2018

1 reference

Loss of cyclosporin and azidopine binding are associated with altered ATPase activity by a mutant P-glycoprotein with deleted phe(335).

31 March 2020

1 reference

Rhodopsin: structural basis of molecular physiology

31 March 2020

1 reference

Serotonergic antagonist effects on trafficking of serotonin 5-HT2A receptors in vitro and in vivo

31 March 2020

1 reference

Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants

31 March 2020

1 reference

Distinct interaction of human and guinea pig histamine H2-receptor with guanidine-type agonists.

31 March 2020

1 reference

Measuring and visualizing single molecular interactions in biology

31 March 2020

1 reference

Cellular signaling by an agonist-activated receptor/Gs alpha fusion protein

31 March 2020

1 reference

Fluorescent labeling of purified beta 2 adrenergic receptor. Evidence for ligand-specific conformational changes

31 March 2020

1 reference

Molecular analysis of beta(2)-adrenoceptor coupling to G(s)-, G(i)-, and G(q)-proteins.

31 March 2020

1 reference

Dopamine D1 and D2 receptor Co-activation generates a novel phospholipase C-mediated calcium signal

31 March 2020

1 reference

Functional differences between human formyl peptide receptor isoforms 26, 98, and G6.

31 March 2020

1 reference

Bisoprolol: a review of its use in chronic heart failure

31 March 2020

1 reference

Treatment of the malignant carcinoid syndrome. Evaluation of a long-acting somatostatin analogue

31 March 2020

1 reference

Dendritic and axonal targeting of type 5 metabotropic glutamate receptor is regulated by homer1 proteins and neuronal excitation

31 March 2020

1 reference

Parathyroid hormone-related protein as a potential target of therapy for cancer-associated morbidity

31 March 2020

1 reference

Selective antagonism of the NPY Y5 receptor does not have a major effect on feeding in rats

31 March 2020

1 reference

Defects in G protein-coupled signal transduction in human disease

31 March 2020

1 reference

Extracellular calcium sensing and extracellular calcium signaling

31 March 2020

1 reference

Rescue of hypogonadotropic hypogonadism-causing and manufactured GnRH receptor mutants by a specific protein-folding template: misrouted proteins as a novel disease etiology and therapeutic target

31 March 2020

1 reference

31 March 2020

1 reference

No ligand binding in the GB2 subunit of the GABA(B) receptor is required for activation and allosteric interaction between the subunits.

31 March 2020

1 reference

Nobel Lecture. G proteins and regulation of adenylyl cyclase

31 March 2020

1 reference

Receptors and G proteins as primary components of transmembrane signal transduction. Part 2. G proteins: structure and function.

31 March 2020

1 reference

G protein-coupled receptor kinases

31 March 2020

1 reference

G protein signaling: insights from new structures.

31 March 2020

1 reference

Structure, function, and control of phosphoinositide-specific phospholipase C

31 March 2020

1 reference

Effects of guanine, inosine, and xanthine nucleotides on beta(2)-adrenergic receptor/G(s) interactions: evidence for multiple receptor conformations

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Differential inhibition of human immunodeficiency virus type 1 fusion, gp120 binding, and CC-chemokine activity by monoclonal antibodies to CCR5

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Voltage-dependent calcium channels: from structure to function

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD1458

1 reference

16 June 2018

Dimensions Publication ID

1016629989

0 references

1 reference

16 June 2018