(Q44342096)

2 December 2017

title

Opioid receptor random mutagenesis reveals a mechanism for G protein-coupled receptor activation (English)

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G protein-coupled receptor

2 December 2017

main subject

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opioid

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author name string

Fabien M Décaillot

1

1 reference

2 December 2017

Katia Befort

2

1 reference

2 December 2017

Dominique Filliol

3

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2 December 2017

ShiYi Yue

4

1 reference

2 December 2017

Philippe Walker

5

1 reference

2 December 2017

Brigitte L Kieffer

6

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2 December 2017

publication date

1 August 2003

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Nature structural biology

2 December 2017

published in

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2 December 2017

volume

10

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2 December 2017

issue

8

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2 December 2017

page(s)

629-636

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Modeling the 3D structure of GPCRs from sequence

2 December 2017

cites work

1 reference

Orphan G-protein-coupled receptors and natural ligand discovery

31 March 2020

1 reference

Crystal structure of rhodopsin: A G protein-coupled receptor

31 March 2020

1 reference

Advances in Determination of a High-Resolution Three-Dimensional Structure of Rhodopsin, a Model of G-Protein-Coupled Receptors (GPCRs)

31 March 2020

1 reference

Activation of rhodopsin: new insights from structural and biochemical studies

31 March 2020

1 reference

Receptor activation: what does the rhodopsin structure tell us?

31 March 2020

1 reference

Movement of retinal along the visual transduction path

31 March 2020

1 reference

Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy

31 March 2020

1 reference

G-Protein coupled receptors: models, mutagenesis, and drug design

31 March 2020

1 reference

Seven-transmembrane receptors: crystals clarify

31 March 2020

1 reference

Opioids: first lessons from knockout mice

31 March 2020

1 reference

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene

31 March 2020

1 reference

Psychotomimesis mediated by kappa opiate receptors

31 March 2020

1 reference

Development of delta opioid peptides as nonaddicting analgesics

31 March 2020

1 reference

Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses

31 March 2020

1 reference

A single nucleotide polymorphic mutation in the human mu-opioid receptor severely impairs receptor signaling

31 March 2020

1 reference

Constitutive activation of the delta opioid receptor by mutations in transmembrane domains III and VII.

31 March 2020

1 reference

Functional role of a conserved motif in TM6 of the rat mu opioid receptor: constitutively active and inactive receptors result from substitutions of Thr6.34(279) with Lys and Asp.

31 March 2020

1 reference

Agonist-independent regulation of constitutively active G-protein-coupled receptors

31 March 2020

1 reference

Role of aromatic transmembrane residues of the delta-opioid receptor in ligand recognition

31 March 2020

1 reference

Activation of the cAMP pathway by the TSH receptor involves switching of the ectodomain from a tethered inverse agonist to an agonist

31 March 2020

1 reference

The 5-hydroxytryptamine(4a) receptor is palmitoylated at two different sites, and acylation is critically involved in regulation of receptor constitutive activity

31 March 2020

1 reference

Involvement of Trp-284, Val-296, and Val-297 of the human delta-opioid receptor in binding of delta-selective ligands

31 March 2020

1 reference

Creating a functional opioid alkaloid binding site in the orphanin FQ receptor through site-directed mutagenesis.

31 March 2020

1 reference

Constitutively active muscarinic receptors

31 March 2020

1 reference

The third extracellular loop of the beta2-adrenergic receptor can modulate receptor/G protein affinity.

31 March 2020

1 reference

Structure and regulation of opioid receptors

31 March 2020

1 reference

Mutation of a conserved serine in TM4 of opioid receptors confers full agonistic properties to classical antagonists

31 March 2020

1 reference

Activation of the alpha1b-adrenergic receptor is initiated by disruption of an interhelical salt bridge constraint

31 March 2020

1 reference

Review: amino acid domains involved in constitutive activation of G-protein-coupled receptors

31 March 2020

1 reference

Constitutively active mutants of rhodopsin

31 March 2020

1 reference

Constitutive activation of the human bradykinin B2 receptor induced by mutations in transmembrane helices III and VI.

31 March 2020

1 reference

Identification by site-directed mutagenesis of residues involved in ligand recognition and activation of the human A3 adenosine receptor

31 March 2020

1 reference

Characterization of heterogeneous mutations causing constitutive activation of the luteinizing hormone receptor in familial male precocious puberty

31 March 2020

1 reference

Conserved helix 7 tyrosine acts as a multistate conformational switch in the 5HT2C receptor. Identification of a novel "locked-on" phenotype and double revertant mutations.

31 March 2020

1 reference

Systematic identification of mutations that constitutively activate the angiotensin II type 1A receptor by screening a randomly mutated cDNA library with an original pharmacological bioassay

31 March 2020

1 reference

Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6.

31 March 2020

1 reference

Constitutive activation of the mu opioid receptor by mutation of D3.49(164), but not D3.32(147): D3.49(164) is critical for stabilization of the inactive form of the receptor and for its expression.

31 March 2020

1 reference

Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins

31 March 2020

1 reference

Evaluation of comparative protein modeling by MODELLER

31 March 2020

1 reference

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

31 March 2020

1 reference

Three-dimensional representations of G protein-coupled receptor structures and mechanisms

31 March 2020

1 reference

Theoretical study of the electrostatically driven step of receptor-G protein recognition

31 March 2020

1 reference

Inverse agonist up-regulates the constitutively active D3.49(164)Q mutant of the rat mu-opioid receptor by stabilizing the structure and blocking constitutive internalization and down-regulation

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NSB950

1 reference

release_zdqjsrccavfg5mdkuoapuo7zva

2 December 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/zdqjsrccavfg5mdkuoapuo7zva

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference